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COVİD-19 Symptoms at First Admission to Hospital

Year 2021, Volume: 13 Issue: 2, 265 - 272, 07.06.2021
https://doi.org/10.18521/ktd.893195

Abstract

Objective: The aim of this study is to profile the complaints in the disease application using a symptom survey in patients presenting with the suspicion of Covid-19 disease and to determine the disease-specific and descriptive characteristics of the initial symptoms in those who were diagnosed with the disease.

Method: In this cross-sectional study, symptoms at first admission were questioned in adult patients who applied to the Covid Outpatient Clinic between 21 December 2020 - 22 January 2021. A total of 43 complaints were analyzed in PCR test positive and negative patients.

Result: 273 (62.0%) first application and 167 (38.0%) control applications were included in the study. The PCR test was positive in 16.5% of the first admissions. The most common complaints in the first admissions with positive PCR test were fatigue (73.0%), headache (64.9%), pain (32.2%), cough (56.8%), sore throat (51.4%), loss of appetite (45.9%) while 15.9% of them were asymptomatic. Odd's rates of significant complaints for PCR positivity were calculated as 2.607 for fever, 2.724 for anorexia, 2.051 for cough, 2.594 for loss of smell, and 2.243 for loss of strength.

Conclusion: Covid-19 is a disease that affects many organs and systems. Comparing the admission symptoms with the PCR test results will contribute to the recognition of the disease at the initial stage. Fever, anorexia, cough, loss of smell and loss of strength were found to be the distinguishing complaints of PCR positivity in our study.

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References

  • 1. WHO Coronavirus (COVID-19) Dashboard [Internet]. Geneva: WHO; 8 May 2021. [cited: 2021 May 8]. Available from: https://covid19.who.int/
  • 2. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727‐33. doi:10.1056/NEJMoa2001017.
  • 3. World Health Organization: Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) [Internet]. Geneva: WHO; 16-24 February 2020. [cited 2021 Feb 27]. Available from: https://www.who. int/docs/default-source/coronaviruse/who-china-joint-mission-onCOVID-19-final-report.pdf
  • 4. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel corona virus in Wuhan, China. The Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5.
  • 5. Hoehl S, Rabenau H, Berger A, Kortenbusch M, Cinatl J, Bojkova D, et al. Evidence of SARS CoV-2 infection in returning travelers from Wuhan, China. N Engl J Med. 2020;382(13):1278-80. doi:10.1056/NEJMc2001899.
  • 6. Chen W, Lan Y, Yuan X, Deng X, Li Y, Cai X, et al. Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity. Emerg Microbes Infect. 2020;9(1):469-73. doi:10.1080/22221751.2020.1732837.
  • 7. Vaira LA, Salzano G, Fois AG, Piombino P, De Riu G. Potential pathogenesis of ageusia and anosmia in COVID-19 patients. Int Forum Allergy Rhinol. 2020;10(9):1103-4. doi:10.1002/alr.22593
  • 8. Huarcaya-Victoria J, Herrera D, Castillo C. Psychosis in a patient with anxiety related to COVID-19: A case report. Psychiatry Res. 2020;289:113052. doi:10.1016/j.psychres.2020.113052
  • 9. Quer  G, Radin  JM, Gadaleta M, Baca-Motes K, Ariniello  L, Ramos E, et al. Wearable sensor data and self-reported symptoms for COVID-19 detection. Nature Medicine. 2021;27:73-7. doi: 10.1038/s41591-020-1123-x
  • 10. Chams N, Chams S, Badran R, Shams A, Araji A, Raad M, et al. COVID-19: A Multidisciplinary Review. Front Public Health. 2020;8:383. doi: 10.3389/fpubh.2020.00383
  • 11. Guan WJ, Ni ZY, Hu Y, Liang W, Ou C, He J, et al. Clinical characteristics of Coronavirus disease 2019 in China. N Engl J Med. 2020;382:1708-20. doi:10.1056/NEJMoa2002032
  • 12. Elshafeey F, Magdi R, Hindi N, Elshebiny M, Farrag N, Mahdy S, et al. A systematic scoping review of COVID‐19 during pregnancy and child birth. Int J Gynaecol Obstet. 2020;150(1):47-52. doi: 10.1002/ijgo.13182
  • 13. Thomas P, Baldwin C, Bissett B, Boden I, Gosselink R, Granger CL, et al. Physiotherapy management for COVID-19 in acute hospital setting: clinical practice recommendations. J Physiother. 2020;66(2):73-82. doi: 10.1016/j.jphys.2020.03.011
  • 14. Chan JF, Yuan S, Kok KH, To KKW, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395(10223):514-23. doi:10.1016/S0140-6736(20)30154-9.
  • 15. Chakraborty C, Sharma AR, Sharma G, Bhattacharya B, Lee SS. SARS-CoV-2 causing pneumonia-associated respiratory disorder (COVID-19):diagnostic and proposed therapeutic options. Eur Rev Med Pharmacol Sci. 2020;24(7): 4016-26. doi:10.26355/eurrev_202004_20871
  • 16. Klein H, Asseo K, Karni N, Benjamini Y, Nir-Paz R, Muszkat M, et al. Onset, duration and unresolved symptoms, including smell and taste changes, in mild COVID-19 infections. A cohort study in Israeli patients. Clin Microbiol Infect. 2021;27(5):769-74. doi:10.1016/j.cmi.2021.02.008.
  • 17. Burak KW, Law S, Rice C, Hu J, Fung CI, Woo AKH, et al. COVID-19 outbreak among physicians at a Canadian curling bonspiel: a descriptive observational study. CMAJ Open. 2021; 9(1): E87-E95. doi:10.9778/cmajo.20200115.
  • 18. Giacomelli A, Pezzati L, Conti F, Bernacchia D, Siano M, Oreni L, et al. Self-reported olfactory and taste disorders in patients with severe acute respiratory Coronavirus 2 infection: a cross sectional study. Clin Infect Dis. 2020;71(15):889-90. doi: 10.1093/cid/ciaa330.
  • 19. Cholankeril G, Podboy A, Aivaliotis VI, Tarlow B, Pham EA, Spencer SP, et al. High prevalence of concurrent gastrointestinal manifestations in patients with severe acute respiratory syndrome Coronavirus 2:early experience from California. Gastroenterology. 2020;159(2):775–7. doi:10.1053/j.gastro.2020.04.008.
  • 20. Savtale S, Hippargekar P, Bhise S, Kothule S. Prevalence of otorhinolaryngological symptoms in Covid 19 patients. Indian J Otolaryngol Head Neck Surg. 2021 Feb 8;1-7. [Online ahead of print]. doi:10.1007/s12070-021-02410-5.
  • 21. Ramani SL, Samet J, Franz CK, Hsieh C, Nguyen CV, Horbinski C, et al. Musculoskeletal involvement of COVID-19: review of imaging. Skeletal Radiol. 2021 Feb 18;1-11. [Online ahead of print]. doi:10.1007/s00256-021-03734-7.
  • 22. Creta M, Sagnelli C, Celentano G, Napolitano l, La Rocca R, Capece M, et al. SARS-CoV-2 infection affects the lower urinary tract and male genital system: a systematic review. J Med Virol. 2021;93(5):3133-42. doi: 10.1002/jmv.26883.
  • 23. Drozdzal S, Rosik J, Lechowicz K, Machaj F, Szostak B, Majewski P, et al. COVID-19: pain management in patients with SARS-CoV-2 infection molecular mechanisms, challenges, and perspectives. Brain Sci. 2020;10(7):465. doi:10.3390/brainsci10070465.
  • 24. Alonso-Matielo H, Oliveira VRS, Oliveira VT, Dale CS. Pain in Covid Era. Front Physiol. 2021;12:624154. doi:10.3389/fphys.2021.624154
  • 25. Karadeli HH, Keskin N. Covid-19 ve Nörolojik Belirtiler. Med Res Rep. 2020;3(Supp 1):51-58
  • 26. Soylemez E, Ertugrul S. Covid-19 ve odyo-vestibüler sistem: sistematik derleme. Selçuk Sağlık Dergisi. 2020;1 (Covid-19 Özel Sayı):33-40
  • 27. Guo G, Liu Z, Zhao S, Guo L, Liu T. Eliminating indefiniteness of clinical spectrum for better screening COVID-19. IEEE J Biomed Health Inform. 2021 Feb 18. [Online ahead of print]. doi:10.1109/JBHI.2021.3060035.
  • 28. Duque MP, Luccacioni H, Costa C, Marques R, Antunes D, Hansen L, et al. COVID-19 symptoms: a case-control study, Portugal, March-April 2020. Epidemiology Infect. 2021 Feb 19;149:e54. doi: 10.1017/S095026882100042X.
  • 29. Gostic K, Gomez ACR, Mummah RO, Kucharski AJ, Lloyd-Smith JO. Estimated effectiveness of symptom and risk screening to prevent the spread of COVID-19. Elife. 2020;9:e55570. doi: 10.7554/eLife.55570
  • 30. Callahan A, Steinberg E, Fries JA, Gombar S, Patel B, Corbin CK, et al. Estimating the efficacy of symptom-based screening for COVID-19. NPJ Digit Med. 2020;3:95. doi:10.1038/s41746-020-0300-0.

Covid-19 Hastalarında Başvuru Şikayetleri

Year 2021, Volume: 13 Issue: 2, 265 - 272, 07.06.2021
https://doi.org/10.18521/ktd.893195

Abstract

Amaç: Bu çalışmada Covid-19 hastalık şüphesi ile başvuran hastalarda semptom sorgulaması yapıp hastalık başvurusundaki şikayetlerin profilini çıkartmak, hastalık tanısı kesinleşenlerde başlangıç semptomlarının hastalığa özgü olma ve tanımlayıcı özelliklerini belirlemek amaçlanmıştır.

Gereç ve Yöntem: Kesitsel desendeki çalışmada 21 Aralık 2020 - 22 Ocak 2021 tarihleri arasında Covid Polikliniğine başvuran yetişkin hastalarda başvuru şikayetleri sorgulanmıştır. Toplam 43 şikayet PCR testi pozitif ve negatif olanlarda analiz edilmiştir.

Bulgular: Çalışmaya 273 (%62,0) ilk başvuru, 167 (%38,0) kontrol başvurusu dahil edilmiştir. PCR testi ilk başvuruların %16,5’inde pozitif sonuçlanmıştır. PCR testi pozitif ilk başvurularda en sık belirtilen şikayetler halsizlik (%73,0), baş ağrısı (%64,9), ağrı (%32,2), öksürük (%56,8), boğaz ağrısı (%51,4), iştahsızlık (%45,9) olarak sıralanırken %15,9 hasta asemptomatikti. PCR pozitifliği için anlamlı şikayetlerin Odd’s oranları ateş 2,607, iştahsızlık 2,724, öksürük 2,051, koku kaybı 2,594 ve güç kaybı 2,243 olarak hesaplandı.

Sonuç: Covid-19 hastalığı birçok organ ve sistemi etkileyen bir hastalıktır. PCR test sonucuna göre başvuru semptomlarını karşılaştırılması hastalığın başlangıç aşamasında tanınmasına katkı sağlayacaktır. Çalışmamızda PCR pozitifliği ayırt edici yakınmaların ateş, iştahsızlık, öksürük, koku duyusu kaybı ve güç kaybı olduğu saptanmıştır.

Project Number

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References

  • 1. WHO Coronavirus (COVID-19) Dashboard [Internet]. Geneva: WHO; 8 May 2021. [cited: 2021 May 8]. Available from: https://covid19.who.int/
  • 2. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727‐33. doi:10.1056/NEJMoa2001017.
  • 3. World Health Organization: Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) [Internet]. Geneva: WHO; 16-24 February 2020. [cited 2021 Feb 27]. Available from: https://www.who. int/docs/default-source/coronaviruse/who-china-joint-mission-onCOVID-19-final-report.pdf
  • 4. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel corona virus in Wuhan, China. The Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5.
  • 5. Hoehl S, Rabenau H, Berger A, Kortenbusch M, Cinatl J, Bojkova D, et al. Evidence of SARS CoV-2 infection in returning travelers from Wuhan, China. N Engl J Med. 2020;382(13):1278-80. doi:10.1056/NEJMc2001899.
  • 6. Chen W, Lan Y, Yuan X, Deng X, Li Y, Cai X, et al. Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity. Emerg Microbes Infect. 2020;9(1):469-73. doi:10.1080/22221751.2020.1732837.
  • 7. Vaira LA, Salzano G, Fois AG, Piombino P, De Riu G. Potential pathogenesis of ageusia and anosmia in COVID-19 patients. Int Forum Allergy Rhinol. 2020;10(9):1103-4. doi:10.1002/alr.22593
  • 8. Huarcaya-Victoria J, Herrera D, Castillo C. Psychosis in a patient with anxiety related to COVID-19: A case report. Psychiatry Res. 2020;289:113052. doi:10.1016/j.psychres.2020.113052
  • 9. Quer  G, Radin  JM, Gadaleta M, Baca-Motes K, Ariniello  L, Ramos E, et al. Wearable sensor data and self-reported symptoms for COVID-19 detection. Nature Medicine. 2021;27:73-7. doi: 10.1038/s41591-020-1123-x
  • 10. Chams N, Chams S, Badran R, Shams A, Araji A, Raad M, et al. COVID-19: A Multidisciplinary Review. Front Public Health. 2020;8:383. doi: 10.3389/fpubh.2020.00383
  • 11. Guan WJ, Ni ZY, Hu Y, Liang W, Ou C, He J, et al. Clinical characteristics of Coronavirus disease 2019 in China. N Engl J Med. 2020;382:1708-20. doi:10.1056/NEJMoa2002032
  • 12. Elshafeey F, Magdi R, Hindi N, Elshebiny M, Farrag N, Mahdy S, et al. A systematic scoping review of COVID‐19 during pregnancy and child birth. Int J Gynaecol Obstet. 2020;150(1):47-52. doi: 10.1002/ijgo.13182
  • 13. Thomas P, Baldwin C, Bissett B, Boden I, Gosselink R, Granger CL, et al. Physiotherapy management for COVID-19 in acute hospital setting: clinical practice recommendations. J Physiother. 2020;66(2):73-82. doi: 10.1016/j.jphys.2020.03.011
  • 14. Chan JF, Yuan S, Kok KH, To KKW, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395(10223):514-23. doi:10.1016/S0140-6736(20)30154-9.
  • 15. Chakraborty C, Sharma AR, Sharma G, Bhattacharya B, Lee SS. SARS-CoV-2 causing pneumonia-associated respiratory disorder (COVID-19):diagnostic and proposed therapeutic options. Eur Rev Med Pharmacol Sci. 2020;24(7): 4016-26. doi:10.26355/eurrev_202004_20871
  • 16. Klein H, Asseo K, Karni N, Benjamini Y, Nir-Paz R, Muszkat M, et al. Onset, duration and unresolved symptoms, including smell and taste changes, in mild COVID-19 infections. A cohort study in Israeli patients. Clin Microbiol Infect. 2021;27(5):769-74. doi:10.1016/j.cmi.2021.02.008.
  • 17. Burak KW, Law S, Rice C, Hu J, Fung CI, Woo AKH, et al. COVID-19 outbreak among physicians at a Canadian curling bonspiel: a descriptive observational study. CMAJ Open. 2021; 9(1): E87-E95. doi:10.9778/cmajo.20200115.
  • 18. Giacomelli A, Pezzati L, Conti F, Bernacchia D, Siano M, Oreni L, et al. Self-reported olfactory and taste disorders in patients with severe acute respiratory Coronavirus 2 infection: a cross sectional study. Clin Infect Dis. 2020;71(15):889-90. doi: 10.1093/cid/ciaa330.
  • 19. Cholankeril G, Podboy A, Aivaliotis VI, Tarlow B, Pham EA, Spencer SP, et al. High prevalence of concurrent gastrointestinal manifestations in patients with severe acute respiratory syndrome Coronavirus 2:early experience from California. Gastroenterology. 2020;159(2):775–7. doi:10.1053/j.gastro.2020.04.008.
  • 20. Savtale S, Hippargekar P, Bhise S, Kothule S. Prevalence of otorhinolaryngological symptoms in Covid 19 patients. Indian J Otolaryngol Head Neck Surg. 2021 Feb 8;1-7. [Online ahead of print]. doi:10.1007/s12070-021-02410-5.
  • 21. Ramani SL, Samet J, Franz CK, Hsieh C, Nguyen CV, Horbinski C, et al. Musculoskeletal involvement of COVID-19: review of imaging. Skeletal Radiol. 2021 Feb 18;1-11. [Online ahead of print]. doi:10.1007/s00256-021-03734-7.
  • 22. Creta M, Sagnelli C, Celentano G, Napolitano l, La Rocca R, Capece M, et al. SARS-CoV-2 infection affects the lower urinary tract and male genital system: a systematic review. J Med Virol. 2021;93(5):3133-42. doi: 10.1002/jmv.26883.
  • 23. Drozdzal S, Rosik J, Lechowicz K, Machaj F, Szostak B, Majewski P, et al. COVID-19: pain management in patients with SARS-CoV-2 infection molecular mechanisms, challenges, and perspectives. Brain Sci. 2020;10(7):465. doi:10.3390/brainsci10070465.
  • 24. Alonso-Matielo H, Oliveira VRS, Oliveira VT, Dale CS. Pain in Covid Era. Front Physiol. 2021;12:624154. doi:10.3389/fphys.2021.624154
  • 25. Karadeli HH, Keskin N. Covid-19 ve Nörolojik Belirtiler. Med Res Rep. 2020;3(Supp 1):51-58
  • 26. Soylemez E, Ertugrul S. Covid-19 ve odyo-vestibüler sistem: sistematik derleme. Selçuk Sağlık Dergisi. 2020;1 (Covid-19 Özel Sayı):33-40
  • 27. Guo G, Liu Z, Zhao S, Guo L, Liu T. Eliminating indefiniteness of clinical spectrum for better screening COVID-19. IEEE J Biomed Health Inform. 2021 Feb 18. [Online ahead of print]. doi:10.1109/JBHI.2021.3060035.
  • 28. Duque MP, Luccacioni H, Costa C, Marques R, Antunes D, Hansen L, et al. COVID-19 symptoms: a case-control study, Portugal, March-April 2020. Epidemiology Infect. 2021 Feb 19;149:e54. doi: 10.1017/S095026882100042X.
  • 29. Gostic K, Gomez ACR, Mummah RO, Kucharski AJ, Lloyd-Smith JO. Estimated effectiveness of symptom and risk screening to prevent the spread of COVID-19. Elife. 2020;9:e55570. doi: 10.7554/eLife.55570
  • 30. Callahan A, Steinberg E, Fries JA, Gombar S, Patel B, Corbin CK, et al. Estimating the efficacy of symptom-based screening for COVID-19. NPJ Digit Med. 2020;3:95. doi:10.1038/s41746-020-0300-0.
There are 30 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Erkan Melih Şahin 0000-0003-1520-8464

Özgül Ocak 0000-0001-8276-0174

Cansu Demiral This is me 0000-0003-2684-8213

Büşra Dönmez This is me 0000-0002-1225-8514

Project Number -
Publication Date June 7, 2021
Acceptance Date May 11, 2021
Published in Issue Year 2021 Volume: 13 Issue: 2

Cite

APA Şahin, E. M., Ocak, Ö., Demiral, C., Dönmez, B. (2021). COVİD-19 Symptoms at First Admission to Hospital. Konuralp Medical Journal, 13(2), 265-272. https://doi.org/10.18521/ktd.893195
AMA Şahin EM, Ocak Ö, Demiral C, Dönmez B. COVİD-19 Symptoms at First Admission to Hospital. Konuralp Medical Journal. June 2021;13(2):265-272. doi:10.18521/ktd.893195
Chicago Şahin, Erkan Melih, Özgül Ocak, Cansu Demiral, and Büşra Dönmez. “COVİD-19 Symptoms at First Admission to Hospital”. Konuralp Medical Journal 13, no. 2 (June 2021): 265-72. https://doi.org/10.18521/ktd.893195.
EndNote Şahin EM, Ocak Ö, Demiral C, Dönmez B (June 1, 2021) COVİD-19 Symptoms at First Admission to Hospital. Konuralp Medical Journal 13 2 265–272.
IEEE E. M. Şahin, Ö. Ocak, C. Demiral, and B. Dönmez, “COVİD-19 Symptoms at First Admission to Hospital”, Konuralp Medical Journal, vol. 13, no. 2, pp. 265–272, 2021, doi: 10.18521/ktd.893195.
ISNAD Şahin, Erkan Melih et al. “COVİD-19 Symptoms at First Admission to Hospital”. Konuralp Medical Journal 13/2 (June 2021), 265-272. https://doi.org/10.18521/ktd.893195.
JAMA Şahin EM, Ocak Ö, Demiral C, Dönmez B. COVİD-19 Symptoms at First Admission to Hospital. Konuralp Medical Journal. 2021;13:265–272.
MLA Şahin, Erkan Melih et al. “COVİD-19 Symptoms at First Admission to Hospital”. Konuralp Medical Journal, vol. 13, no. 2, 2021, pp. 265-72, doi:10.18521/ktd.893195.
Vancouver Şahin EM, Ocak Ö, Demiral C, Dönmez B. COVİD-19 Symptoms at First Admission to Hospital. Konuralp Medical Journal. 2021;13(2):265-72.