COVID-19 Hastalarının Bazı Biyokimyasal Parametrelerinin Biyobelirteç Olarak Değerlendirilmesi

Year 2023, Volume: 15 Issue: 2, 248 - 256, 22.06.2023

Ümit Karadeniz , Serpil Uğraş , Pınar Göç Rasgele

https://doi.org/10.18521/ktd.1268351

Abstract

Amaç: SARS-CoV-2, Dünya çapında 664 milyondan fazla doğrulanmış vaka ve 6,7 milyondan fazla ölümle küresel bir pandemiye neden olmuştur. Pandemide tanı ve tedaviye yardımcı olmak amacıyla bazı biyokimyasal ve hematolojik parametrelerin COVID-19 ile ilişkisi üzerine birçok çalışma yapılmıştır. Ancak pek çok bilgi tam değildir ve verilerde çelişkiler vardır. Bu çalışmada COVID-19 hastaları ve sağlıklı bireyler de dahil olmak üzere bireylerin biyokimyasal parametrelerinin yaş ve cinsiyet ilişkisi incelenmiştir.
Gereç ve Yöntem: Şubat 2022-Kasım 2022 tarihleri arasında Pandemi Polikliniği'ne COVID-19 şüphesiyle başvuran 317 kişi laboratuvar testleri ile değerlendirilmiştir. İstatistiksel analiz, IBM SPSS 20.0 kullanılarak yapılmıştır.
Bulgular: COVID-19' hastası erkek hastalarda ÜREA, KREA, FER, AST, ALT, HSTI, CK, CRP gibi değerlerin COVID-19 hastası kadın hastalara göre daha yüksek olduğu belirlenmiştir. Ayrıca 18-65 yaş arası COVID-19 hastalarında GLU, FER, AST, LDH, HSTI, CK ve CRP gibi parametrelerde istatistiksel olarak anlamlı artış olduğu tespit edilmiştir.
Sonuç: Prognostik öneme sahip birçok biyobelirteçlerin pahalı olmasına karşı COVID-19 enfeksiyonu olan hastalarda hastalığın izlenmesi amacıyla basit ve uygun maliyetli FER, AST, LDH, HSTI, CK ve CRP gibi biyokimyasal parametrelerin biyobelirteç olarak kullanımı sözkonusudur.

Keywords

Biyokimyasal parametreler, Biyobelirteç COVID-19, laboratuvar tanısı, SARS-CoV-2

Evaluation of Some Biochemical Parameters of COVID-19 Patients as Biomarkers

Abstract

Objective: SARS-CoV-2 has caused a global pandemic with more than 664 million confirmed cases and more than 6.7 million deaths worldwide. In pandemic, several studies have been done about the relationship of some biochemical and hematological parameters with COVID 19 in order to assist diagnosis and treatment. However, a lot of information is not completely complete and there are contradictions in the data. In the present study, it was focused to compare the biochemical parameters of patients and healthy individuals due to COVID 19 by investigating the relationship between age and gender.
Methods: The 317 individuals who consulted to the Pandemic Outpatient Clinic with the suspicion of COVID 19 between February 2022 and November 2022 were evaluated by laboratory tests. In present study, biochemical parameter values of individuals with positive and negative COVID 19 test outcomes were used as material. These biochemical parameters were compared statistically based on different age ranges and gender groups.
Results: It was ascertained that the values such as UREA, KREA, FER, AST, ALT, HSTI, CK and CRP in male patients with COVID 19 were higher than female patients with COVID 19. Moreover, it was detected that there was a statistically significant increase in parameters such as GLU, FER, AST, LDH, HSTI, CK and CRP in COVID 19 patients aged 18-65 years.
Conclusions: Many biomarkers of prognostic importance are expensive, ordinary and pricey-effective biomarkers such as FER, AST, LDH, HSTI, CK and CRP can be used to monitor disease in patients with COVID 19 infection.

Keywords

Biochemical parameters, Biomarkers, COVID-19, laboratory diagnosis, SARS-CoV-2

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