Alerjik Hastalıklarda Fare, Sıçan Modelleri

Year 2017, Volume: 9 Issue: 2, 186 - 193, 15.03.2017

Doç. Dr. Meral Karaman

Abstract

Öz

Son yıllarda alerjik hastalıkların görülme sıklığının artması tanı ve tedavi sürecin-de arayışları da beraberinde getirmiştir. Alerjik hastalıkların hayvan modelleri, im-munolojik, fizyolojik ve histopatolojik düzeyde patogenezi anlayabilmek, korunmave tedavide mevcut bilgilere yenilerini ekleyebilmek adına ciddi katkılarda bulun-maktadır. Biyomedikal araştırmalar için kullanılacak olan laboratuvar hayvanı türü-ne ait anatomik, fizyolojik ve biyolojik özelliklerin bilinmesi, insandaki hastalık sü-recine benzeyen modellerin oluşturulmasında, güvenilir ve tekrarlanabilir sonuçlarelde edilmesinde önemli bir basamaktır.  Bu açıdan bakıldığında alerjik hastalıkla-rın laboratuvar hayvanı modelleri için çok çeşitli hayvan türleri kullanılabilir. An-cak bu derleme makalede; etik açıdan kabul edilebilir, üretim, yetiştirme ve barın-dırma ortamları daha kolay standardize edilebilir, ekonomik açıdan ulaşılabilir ol-ması nedeniyle fare ve sıçan modelleri üzerinde durulmuştur.

Keywords

Astım, Alerjik rinit, Atopik dermatit, hayvan modeli

In Allergic Diseases Mouse, Rat Models

Abstract

Abstract

During the past few years, the increasing prevalence of allergies has brought about a search for new techniques of diagnosis and treatment. Animal models of allergies play a major role in understanding the pathogenesis at immunological, physiological and histopatological levels as well as elaborating on the existing treatmentmethods. It is indispensable to know the anatomic, physiological and biological characteristics of the laboratory animals used in biomedical research in order to obtainrepeatable and reliable outcomes in the animal models imitating the situation in humans. From this aspect, a variety of animals can be utilized to model allergic illnes-ses. Yet, in this compiled article, mouse and rat models were emphasized for theyare ethical, their production and growing environments are easily standardizable andthey are more feasible economically.

Keywords

Asthma, Allergic rhinitis, Atopic dermatitis, animalmodel

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