Multiple Skleroz Tanılı Çocukların Demografik ve Klinik Özelliklerinin Retrospektif Olarak Değerlendirilmesi

Year 2022, , 139 - 143, 31.05.2022

Didem Yüksel Yılmaz , Figen Yardımcı

https://doi.org/10.30934/kusbed.1060124

Abstract

Amaç: Bu retrospektif çalışma, multiple skleroz (MS) tanısı ile izlenen çocuk ve adölesan hastaların demografik ve klinik özelliklerini sunmak amacıyla yapılmıştır.
Yöntem: Araştırma verileri, 10-25 Aralık 2021 tarihleri arasında İzmir’de bulunan üç hastanede izlenen pediatrik MS tanılı olguların, demografik verileri, başvuru yakınmaları, klinik bulguları veuygulanan tedavileri veri toplama formu ile retrospektif olarak elde edilmiştir.
Bulgular: Bu retrospektif çalışmada 40 hastanın verileri incelenmiştir. Hastaların %77,5’i kız, yaş ortalaması 16 yaş ± 2,3 ve ilk atak yaş ortalaması 13,9 yaş olarak bulunmuştur. Hastaların yaklaşık yarısı interferon beta 1a subkutan, %27,5’i glatiramer asetat tedavisi aldığı ve ilaç kullanım sürelerinin ortalama 18 ay olduğu görülmüştür. Hastaların %20’si ise herhangi bir tedavi almamıştır. Tedavi alan hastaların %31,2’si ilaçtan dolayı yan etki yaşamış ve %15,6’sı yan etki nedeniyle tedaviye uyum sağlayamamıştır. Uyum sağlayamayan tüm hastaların tedavileri değiştirilmiştir. Çalışmada 3 olguda ailesel MS hastalığı öyküsü bulunmaktadır. Hastaların %72,5’i ilk ataklarında 3-10 gün intravenöz metilprednizolon tedavisi almış, tedavi alanların yarısından fazlası (%79,2) metilprednizolon tedavisi sonrası tama yakın/tamamen düzelme sağlamıştır. Hastaların %80’i relapsing-remitting MS ve %20’si klinik/radyolojik izole sendrom formundadır.
Sonuç: Çocukluk çağında MS hastalığı, kızlarda daha sık ve en sık relapsing-remitting formunda görülmektedir. Çocukluk çağı MS tedavisinde büyük oranda interferon beta 1a ve glatiramer asetat kullanılmaktadır. İmmünomodülatör tedavi ile atak sayısında azalma, genişletilmiş özürlülük durum ölçeği puan ortalamasında düşme ile iyilik hali sağlanabilmektedir.

Keywords

adölesan, multiple skleroz, retrospektif, Çocuk

Supporting Institution

Yoktur.

Project Number

Yoktur.

Thanks

Yoktur.

Retrospective Evaluation of Demographic and Clinical Characteristics of Children with Multiple Sclerosis

Abstract

Objective: This retrospective study was conducted to present the clinical features and treatment experiences of child and adolescent patients diagnosed with multiple sclerosis (MS).
Methods: Demographic data, current complaints and clinical findings of patients in addition to treatment modalities applied and compliance of pediatric patients with MS to treatments were evaluated retrospectively in the context of a data collection form.
Results: The data of 40 patients were analyzed in this retrospective study. Of our patients 77.5% were female and the mean age of participants was 16 and the mean of age when patients experienced the first attack was 13.9% approximately half of our patients were receiving interferon beta 1a subcutaneously and 27.5% were receiving glatiramer acetate and their mean duration of use was 18 months. The ratio of patients who did not receive any treatment was 20%. Of the patients receiving treatment, 31.2% experienced side effects due to the drug and 15.6% could not comply with the treatment because of side effects of treatment. The treatment of all patients who failed to comply with the current treatment was changed. In our study, there was a family history of MS in 3 cases. Of patients, 72.5% received intravenous methylprednisolone treatment for between 3 and 10 days during the the first episodes of their illness, and more than half (79.2%) of the patients got completely or nearly completely better. Of patients, 80% had relapsing-remitting MS and 20% had clinical / radiological isolated syndrome.
Conclusion: Childhood MS is seen more commonly in girls and the most frequently in the relapsing-remitting form. Interferon beta 1a and glatiramer acetate are mostly used in the treatment of childhood MS. With immunomodulatory treatment, a decrease both in the number of attacks and in the average expanded disability status scale score, besides an improvement for health can be provided.

Keywords

Child, adolescent, multiple sclerosis, retrospective

Project Number

Yoktur.

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