Age-Related Evaluation of Neutrophil-to-Lymphocyte Ratio in Women with Polycystic Ovary Syndrome: A Retrospective Study

Year 2026, Volume: 12 Issue: 1, 76 - 80, 20.01.2026

Çağlayan Ateş , Mustafa Bakırcı

https://doi.org/10.30934/kusbed.1830233

Abstract

Objective: To evaluate the effect of age on the neutrophil-lymphocyte ratio (NLR), a marker of systemic inflammation, and other hematological parameters in women diagnosed with polycystic ovary syndrome (PCOS).
Materials and Methods: This retrospective study examined 280 women aged 18–43 who had been diagnosed with PCOS according to the Rotterdam criteria between May 2022 and May 2024. The patients were divided into four groups according to their age: Group 1 (18–24 years, n = 100); Group 2 (25–30 years, n = 130); Group 3 (31–35 years, n = 37); and Group 4 (36–43 years, n = 13). The Kruskal–Wallis test was used to compare neutrophil, lymphocyte, and NLR levels between groups. Spearman correlation analysis was used to evaluate the relationship between age and inflammatory parameters. The independent effect of age on NLR was examined using multivariate linear regression analysis.
Results: No significant difference in NLR levels was found between age groups (p = 0.160). However, the neutrophil count was significantly lower in Group 3 than in the other groups (p = 0.013). A weak negative correlation was found between age and neutrophil count (r = -0.142, p = 0.024), but no significant correlation was found between age and NLR (r = 0.084, p = 0.162). Multivariate regression analysis revealed that age had no independent effect on NLR (β = -0.088, p = 0.156), whereas BMI positively affected NLR (β = +0.176, p = 0.005).
Conclusion: In this cohort of women with PCOS, NLR did not show a significant association with age, whereas it was associated with BMI. These findings emphasise the importance of considering metabolic factors when evaluating the inflammatory process in PCOS.

Keywords

Polycystic ovary syndrome , neutrophil-lymphocyte ratio , age , inflammation , body mass index

Ethical Statement

The study was approved by the Local Ethics Committee of Yozgat Bozok University (2025-GOKAEK-258-2025.04.30-463). All authors involved in the study fully complied with the principles of the Declaration of Helsinki.

Supporting Institution

Yozgat Bozok University

Polikistik Over Sendromu Olan Kadınlarda Nötrofil-Lenfosit Oranının Yaşa Göre Değerlendirilmesi: Retrospektif Bir Çalışma

Abstract

Amaç: Polikistik over sendromu (PCOS) tanılı kadınlarda yaşın, sistemik inflamasyonun bir göstergesi olan nötrofil-lenfosit oranı (NLR) ve diğer hematolojik parametreler üzerindeki etkisini değerlendirmek.
Yöntem: Bu retrospektif çalışmaya, Mayıs 2022 ile Mayıs 2025 tarihleri arasında Rotterdam kriterlerine göre PCOS tanısı konmuş 18-43 yaş arası 280 kadın dahil edildi. Hastalar yaşlarına göre dört gruba ayrıldı: Grup 1 (18-24 yaş, n=100), Grup 2 (25-30 yaş, n=130), Grup 3 (31-35 yaş, n=37) ve Grup 4 (36-43 yaş, n=13). Gruplar arasında nötrofil, lenfosit ve NLR düzeyleri Kruskal-Wallis testi ile karşılaştırıldı. Yaş ile inflamatuvar parametreler arasındaki ilişki Spearman korelasyon analizi ile değerlendirildi. Yaşın NLR üzerindeki bağımsız etkisi çok değişkenli doğrusal regresyon analizi ile incelendi.
Bulgular: Yaş grupları arasında NLR düzeylerinde anlamlı farklılık saptanmadı (p=0,160). Ancak nötrofil sayısı Grup 3'te diğer gruplara göre anlamlı şekilde düşüktü (p=0,013). Yaş ile nötrofil arasında zayıf negatif korelasyon bulundu (r=-0,142, p=0,024), ancak yaş ile NLR arasında anlamlı korelasyon saptanmadı (r=0,084, p=0,162). Çok değişkenli regresyon analizinde yaşın NLR üzerinde bağımsız etkisi olmadığı (β=-0,088, p=0,156), buna karşın vücut kitle indeksinin (VKİ) NLR'yi pozitif yönde etkilediği gösterildi (β=+0,176, p=0,005).
Sonuç: PCOS'lu kadınlardan oluşan bu kohortta, NLR yaşla anlamlı bir ilişki göstermezken, VKİ ile ilişkiliydi. Bu bulgular, PCOS'taki inflamatuvar sürecin değerlendirilmesinde metabolik faktörlerin önemini vurgulamaktadır.

Keywords

Polikistik over sendromu , nötrofil-lenfosit oranı , yaş , inflamasyon , vücut kitle indeksi

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