EDTA - Dependent Pseudothrombocytopenia: Case Report

Year 2018, , 60 - 62, 30.05.2018

Berrin Öztaş , Yunus Gören Şebnem Ciğerli Erdinç Serin Ertuğrul Altınbilek

https://doi.org/10.30934/kusbed.383708

Abstract

EDTA-dependent pseudothrombocytopenia is the
mismeasurement of the thrombocyte count in EDTA anticoagulated blood, due to
aggregation of these cells. The situation may be mistaken with true
thrombocytopenia and may lead to incorrect diagnosis and treatment, and to loss
of power and time. The aim of this case report was to draw attention to
EDTA-dependent pseudotyhrombocytopenia, which is one of the possible causes of
thrombocytopenia. Case; isolated thrombocytopenia was detected in the EDTA
blood sample sent to our laboratory, which had been obtained from a patient
hospitalized with the diagnosis of epilepsy in the red area of the emergency
medicine unit of our hospital. Another blood sample was collected into
Na-citrate, in which the thrombocyte count was observed to be within the normal
ranges. Furthermore, thrombocyte aggregations were observed in the peripheral
blood smears prepared from the sample with EDTA, whereas no aggregation was
observed from the sample with citrate.

Keywords

EDTA, pseudothrombocytopenia, peripheral blood smear, pseudothrombocytopenia, thrombocytopenia

EDTA’ya Bağlı Psödotrombositopeni: Olgu Sunumu

Abstract

EDTA’ya bağlı psödotrombositopeni; EDTA ile
antikoagüle edilmiş kanda trombositlerin kümeleşmesi sonucu, normalden düşük
olarak saptanması durumudur. Bu durum gerçek trombositopeni ile karışabilmekte,
yanlış tanı ve tedavi uygulanmasına, gereksiz işgücü ve zaman kaybına neden
olabilmektedir. Bu olgu trombositopeninin olası nedenlerinden biri olan EDTA’ya
bağlı psödotrombositopeniye dikkat çekmek amacıyla sunulmuştur. Olgu;
hastanemiz acil tıp kırmızı alanında epilepsi tanısı ile yatan hastadan alınıp
acil gözetimli hizmet laboratuvarımıza gönderilen EDTA’lı kan numunesinde izole
trombosit düşüklüğü tesbit edilmiştir. Hastadan yeniden alınan Na-sitratlı
numunede trombosit sayısının referans değerler arasında olduğu tesbit
edilmiştir. Ayrıca hem EDTA’lı hem de Na-sitratlı numuneden yapılan periferik
yayma örneklerinde EDTA’lı numunede trombosit kümeleri gözlenirken, Sitratlı
numunede gözlenmemiştir.

Keywords

EDTA, periferik yayma, psödotrombositopeni, trombositopeni

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