Rekürren Aftöz Stomatitli Hastalarda Total Oksidan Durum, Total Antioksidan Durum ve Oksidatif Stres İndeksinin Değerlendirilmesi

Year 2022, Volume: 8 Issue: 1, 88 - 91, 21.03.2022

Hüseyin Kurku Cahit Yavuz

https://doi.org/10.30934/kusbed.1033896

Cited By: 1

Abstract

Amaç: Çalışmamızda rekürren aftöz stomatitli (RAS) hastalarda total oksidan durum (TOS), total antioksidan durum (TAS) ve oksidatif stress indeksi (OSI) parametrelerini değerlendirmeye çalıştık.
Yöntem: Dermatoloji polikliniğine oral ülser şikayeti ile başvuran ve RAS tanısı alan 23 kadın ve 17 erkek olmak üzere yaş ortalaması 29 olan toplam 40 hasta ile 33 kadın ve 16 erkek olmak üzere yaş ortalaması 24 olan 49 sağlıklı gönüllü çalışmaya dahil edildi.
Bulgular: TOS ve OSI değerleri RAS grubunda kontrol grubuna göre istatistiksel olarak anlamlı derecede yüksek bulunmuştur. İki grup arasındaki TAS değerleri karşılaştırıldığında ise RAS grubuna ait TAS değeri ile kontrol grubuna ait TAS değeri arasında fark bulunamamıştır.
Sonuç: RAS’li hastalarda TOS, TAS ve OSI değerleri oksidatif süreç lehine değişmektedirler. RAS patogenezinde oksidan maddeler ve antioksidan aktif maddeler önemlidir.

Keywords

Rekürren Aftöz Stomatit, Total Oksidan Durum, Total Antioksidan Durum, Oksidatif Stres İndeksi

Evaluation of Total Oxidant Status, Antioxidant Status and Oxidative Stress Index in Patients with Recurrent Aphthous Stomatitis

Abstract

Objective: We try to evaluate total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) in patients with recurrent aphtous stomatitis (RAS) in our study.
Methods: A total of 40 patients, 23 female and 17 male, with a mean age of 29, who applied to the dermatology outpatient clinic with the complaint of oral ulcers and were diagnosed with RAS and a total of 49 healthy controls, 33 female and 16 male, with a mean age of 24, were included in the study.
Results: The TOS and OSI values of the RAS group were statistically significantly higher than the values of the control group. When the TAS values of both groups were compared; the TAS value of the RAS group was statistically indifferent from the TAS value of the control group.
Conclusion: In patients with RAS, serum TOS, serum TAS and OSI values are affected in favour of oxidative processes. In the pathogenesis of RAS, oxidant substances and antioxidant-active substances are important.

Keywords

Recurrent Aphtous Stomatitis, Total Oxidant Status, Total Antioxidant Status, Oxidative Stress Index

References

• Cui RZ, Bruce AJ, Rogers RS 3rd. Recurrent aphthous stomatitis. Clin Dermatol 2016;34:475–481.
• Akintoye SO, Greenberg MS. Recurrent aphthous stomatitis. Dent Clin North Am 2014;58:281–297. doi:10.1016/j.cden.2013.12.002.
• Shashy RG, Ridley MB. Aphthous ulcers: a difficult clinical entity. Am J Otolaryngol 2000;21:389-393. doi:10.1053/ajot.2000.18872.
• Chavan M, Jain H, Diwan N, Khedkar S, Shete A, Durkar S. Recurrent aphthous stomatitis: a review. J Oral Pathol Med 2012;41:577–583. doi:10.1111/j.1600-0714.2012.01134.x.
• Slebioda Z, Szponar E, Kowalska A. Etiopathogenesis of recurrent aphthous stomatitis and the role of immunologic aspects: literatüre review. Arch Immunol Ther Exp (Warsz) 2014;62:205–215. doi:10.1007/s00005-013-0261-y.
• Du Q, Ni S, Fu Y, Liu S. Analysis of dietary related factors of recurrent aphthous stomatitis among college students. Evid Based Complement Alternat Med 2018;2018:2907812. doi:10.1155/2018/2907812.
• Ziaudeen S, Ravindran R. Assessment of oxidant-antioxidant status and stress factor in recurrent aphthous stomatitis patients: case control study. J Clin Diagn Res 2017;11:01–4. doi:10.7860/JCDR/2017/22894.9348.
• Akoglu G, Metin A, Kilinc F, et al. Total serum oxidant/antioxidant status and arylesterase activity in recurrent aphthous stomatitis. Ann Dermatol 2013;25:273–277. doi:10.5021/ad.2013.25.3.273.
• Tarpey MM, Wink DA, Grisham MB. Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations. Am J Physiol Regul Integr Comp Physiol 2004;286:431-444. doi:10.1152/ajpregu.00361.2003.
• Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005;38:1103-1111. doi:10.1016/j.clinbiochem.2005.08.008.
• Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 2004;37:277-285. doi:10.1016/j.clinbiochem.2003.11.015.
• Scully C, Porter S. Oral mucosal disease: recurrent aphtous stomatitis. Br J Oral Maxillofac Surg. 2008;46:198-206. doi:10.1016/j.bjoms.2007.07.201.
• Huling LB, Baccaglini L, Choquette L, Feinn RS, Lalla RV. Effect of stressful life events on the onset and duration of recurrent aphthous stomatitis. J Oral Pathol Med 2012;41:149–152.
• Tugrul S, Koçyigit A, Dogan R, et al. Total antioxidant status and oxidative stress in recurrent aphthous stomatitis. Int J Dermatol 2016;55:e130–135. doi:10.1111/j.1600-0714.2011.01102.x.
• Cimen MY, Kaya TI, Eskandari G, Tursen U, Ikizoglu G, Atik U. Oxidant/antioxidant status in patients with recurrent aphthous stomatitis. Clin Exp Dermatol 2003; 28:647–650. doi:10.1046/j.1365-2230.2003.01415.x
• Karincaoglu Y, Batcioglu K, Erdem T, Esrefoglu M, Genc M. The levels of plasma and salivary antioxidants in the patient with recurrent aphthous stomatitis. J Oral Pathol Med 2005;34:7–12. doi:10.1111/j.1600-0714.2004.00253.x.
• Arikan S, Durusoy C, Akalin N, Haberal A, Seckin D. Oxidant/antioxidant status in recurrent aphthous stomatitis. Oral Dis 2009; 15: 512–515. doi:10.1111/j.1601-0825.2009.01580.x
• Caglayan F, Miloglu O, Altun O, Erel O, Yilmaz AB. Oxidative stress and myeloperoxidase levels in saliva of patients with recurrent aphthous stomatitis. Oral Dis 2008; 14: 700–704. doi:10.1111/j.1601-0825.2008.01466.x.
• Sepici-Dinçel A, Ozkan Y, Yardim-Akaydin S, Kaymak-Karataş G, Onder M, Simşek B. The association between total antioxidant status and oxidative stress in Behçet’s disease. Rheumatol Int 2006;26:1005-1009. doi:10.1007/s00296-006-0126-3.
• Lewkowicz N, Lewkowicz P, Kurnatowska A, et al. Innate immune system is implicated in recurrent aphthous ulcer pathogenesis. J Oral Pathol Med 2003;32:475-481. doi:10.1034/j.1600-0714.2003.00181.x.
• Zhang Z, Zhang Q, Xue Y, Chen G, Wu Z, Fang H. Serum levels of total antioxidant status, nitric oxide and nitric oxide synthase in minor recurrent aphthous stomatitis patients. Medicine 2019;98:e14039. doi:10.1097/MD.0000000000014039
• Ekinci A, Demir E, Ekinci H. Serum prolidase and oxidative stress levels in patients with recurrent aphthous stomatitis: a prospective, controlled study. Indian J Dermatol Venereol Leprol 2020;86:18-23. doi:10.4103/ijdvl.IJDVL_20_18.