COVID-19-Related Biochemical and Hematological Parameters: A Single-Center Population Index Study

Year 2022, Volume: 8 Issue: 1, 54 - 58, 21.03.2022

Fatih Kar Selma Yılmaz Ahmet Musmul Hakan Şentürk

https://doi.org/10.30934/kusbed.982963

Cited By: 1

Abstract

Objective: We aimed to examine the effects of COVID-19 on biochemical and hematological parameters such as liver and kidney function tests, electrolyte levels and inflammatory markers.
Methods: The research was carried out on 10269 patients who applied to Eskişehir City Hospital between 01.03.2020 and 01.10.2020 with positive and negative COVID-19 test results. Included patients were diagnosed with COVID-19 by real-time polymerase chain reaction and computed tomography Biochemical parameters were examined in the samples of two groups with positive and negative COVID-19 test results. In addition, hematological parameters were obtained retrospectively.
Results: BASO%, EOS#, EOS%, HCT, HGB, LYM#, LYM%, MCHC, MCV, MONO#, MONO%, MPV, NEU#, NEU%, PCT and PLT (p<0.05). There was no statistical difference in BASO# and MCH parameters. BASO%, EOS%, HCT, LYM#, LYM%, MCHC, MONO%, NEU%, PCT and RBC parameters in COVID-19 positive patients were higher than in COVID-19 negative patients. Other parameters were lower in positive patients than in negative patients (p<0.05). There was a statistical difference between the groups in all biochemistry test results except potassium and procalcitonin parameters (p<0.05). ALP, ALT, AST, Direct Bilirubin, Total Bilirubin, BUN, CRP, D-Dimer, Ferritin, GGT, Creatinine, LDH and Troponin data obtained from COVID-19 positive patients were higher than control group. Albumin, Chlorine, Iron, Sodium and total protein levels were lower in positive patients than in negative patients (p<0.05).
Conclusion: Biochemical variants found in COVID-19 positive patients that may indicate multi-organ dysfunction. Abnormalities in some biochemical indices, such as liver and kidney function tests, may reflect the severity of the disease to some degree. These comprehensive biochemical and hematological indicators can be used to create indexes and panels, taking into account the clinical management of the disease.

Keywords

COVID-19, SARS-CoV-2, Hematological parameters, Biochemical biomarkers

COVID-19 İlişkili Biyokimyasal ve Hematolojik Parametreler: Tek merkezli Popülasyon İndeks Çalışması

Abstract

Amaç: COVID-19’un karaciğer ve böbrek fonksiyon testleri, elektrolit düzeyleri ve inflamatuar belirteçler gibi biyokimyasal ve hematolojik parametreler üzerindeki etkilerinin incelenmesini amaçladık.
Yöntem: Araştırma 01.03.2020-01.10.2020 tarihleri arasında Eskişehir Şehir Hastanesine başvuran COVID-19 test sonucu pozitif ve negatif olan 10269 hasta üzerinde gerçekleştirildi. Dahil edilen hastaların COVID-19 tanıları gerçek zamanlı polimeraz zincir reaksiyonu ve bilgisayarlı tomografi akciğer taraması ile yapıldı. COVID-19 pozitif ve negatif test sonucuna sahip iki grubun numunelerinde biyokimyasal parametreler incelendi. Ayrıca hematolojik parametreler retrospektif olarak elde edildi.
Bulgular: BASO%, EOS#, EOS%, HCT, HGB, LYM#, LYM%, MCHC, MCV, MONO#, MONO%, MPV, NEU#, NEU%, PCT ve PLT değerlerinde gruplar arasında istatistiksel fark vardı (p<0,05). BASO# ve MCH parametrelerinde ise istatistiksel fark tespit edilmedi. Değerler incelendiğinde; COVID-19 pozitif hastalarındaki BASO%, EOS%, HCT, LYM#, LYM%, MCHC, MONO%, NEU%, PCT ve RBC parametreleri COVID-19 negatif hastalara göre daha yüksekti. Diğer parametreler ise pozitif hastalarda negatif hastalara göre daha düşüktü (p<0,05). Potasyum ve prokalsitonin parametreleri haricindeki tüm biyokimya test sonuçlarında gruplar arasında istatistiksel olarak fark tespit edildi (p<0,05). COVID-19 pozitif hastalarından elde edilen ALP, ALT, AST, Direkt Bilirubin, Total Bilirubin, BUN, CRP, D-Dimer, Ferritin, GGT, Kreatinin, LDH ve Troponin verileri negatif hastalara göre daha yüksekti. Albümin, Klor, Demir, Sodyum ve total protein düzeyleri ise pozitif hastalarda negatif hastalara göre daha düşüktü (p<0,05).
Sonuç: COVID-19 pozitif hastalarda, çoklu organ işlev bozukluğunu gösterebilecek biyokimyasal değişkenler bulundu. Karaciğer ve böbrek fonksiyon testleri gibi bazı biyokimyasal indekslerdeki anormallikler, hastalığın şiddetini bir dereceye kadar yansıtabilir. Bu kapsamlı biyokimyasal ve hematolojik göstergeler, hastalığın klinik yönetiminde dikkate alınarak indeks ve panel oluşturmada kullanılabilir.

Keywords

COVID-19, SARS-CoV-2, Hematolojik parametreler, biyokimyasal biyobelirteçler

References

• Dünya Sağlık Örgütü: Coronavirus (COVID-19) Dashboard. Erişim: https://covid19.who.int (Erişim tarihi: 10.07.2021)
• TUBITAK COVID-19 Data Portal Turkey. Erişim: https://covid19.tubitak.gov.tr/turkiyede-durum (Erişim tarihi: 10.07.2021)
• Liu R, Han H, Liu F, et al. Positive rate of RT-PCR detection of SARS-CoV-2 infection in 4880 cases from one hospital in Wuhan, China, from Jan to Feb 2020. Clin Chim Acta. 2020;505:172–175. doi:10.1016/j.cca.2020.03.009
• Chen X, Yang Y, Huang M, et al. Differences between COVID-19 and suspected then confirmed SARS-CoV-2-negative pneumonia: a retrospective study from a single center. J Med Virol. 2020;92(9),1572-1579. doi:10.1002/jmv.25810
• Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 2020;368:m1091. doi: 10.1136/bmj.m1091
• Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al. Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China. Clin Infect Dis. 2020;71(15):762-768. doi: 10.1093/cid/ciaa248.
• Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061–1069. doi: 10.1001/jama.2020.1585
• Wang D, Li R, Wang J, et al. Correlation analysis between disease severity and clinical and biochemical characteristics of 143 cases of COVID-19 in Wuhan, China: a descriptive study. BMC Infectious Diseases. 2020;20:519. doi: 10.1186/s12879-020-05242-w
• Ferrari D, Motta A, Strollo M, Banfi G, Locatelli M. Routine blood tests as a potential diagnostic tool for COVID-19. Clin Chem Lab Med. 2020;58(7):1095-1099. doi:10.1515/cclm-2020-0398
• Mardani R, Vasmehjani AA, Zali F, et al. Laboratory Parameters in Detection of COVID-19 Patients with Positive RT-PCR; a Diagnostic Accuracy Study. Arch Acad Emerg Med. 2020;8(1):e43.
• Zhao D, Yao F, Wang L, et al. A comparative study on the clinical features of COVID-19 pneumonia to other pneumonias. Clin Infect Dis. 2020;71(15):756-761. doi:10.1093/cid/ciaa247
• Fu Y, Cheng Y, Wu Y. Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools. Virol Sin. 2020;35(3):266-271. doi: 10.1007/s12250-020-00207-4
• Hui DSC, Wong PC, Wang C. SARS: clinical features and diagnosis. Respirology. 2003;8(1):20–24. doi:10.1046/j.1440-1843.2003.00520.x
• Xie H, Zhao J, Lian N, Lin S, Xie Q, Zhuo H. Clinical characteristics of non-ICU hospitalized patients with coronavirus disease 2019 and liver injury: A retrospective study. Liver Int. 2020;40(6): 1321-1326. doi:10.1111/liv.14449
• Deng Y, Liu W, Liu K, et al. Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study. Chin Med J (Engl). 2020;133(11): 1261-1267. doi:10.1097/CM9.0000000000000824.
• Guan GW, Gao L, Wang JW, et al. Exploring the mechanism of liver enzyme abnormalities in patients with novel coronavirus-infected pneumonia. Zhonghua gan zang bing za zhi= Zhonghua ganzangbing zazhi= Chinese journal of hepatology. 2020;28(2):100-106. doi:10.3760/cma.j.issn.1007-3418.2020.02.002.
• Huang D, Huan Y, He Y, et al. Diagnostic Value of Hematological and Biochemical Parameters Combinations for Predicting Coronavirus Disease 2019 (COVID19) in Suspected Patients, The American Journal of the Medical Sciences Am J Med Sci 2021;362(4):387-395. doi: 10.1016/j.amjms.2021.04.006.
• Zhang Y, Zheng L, Liu L, Zhao M, Xiao J, Zhao Q. Liver impairment in COVID-19 patients: a retrospective analysis of 115 cases from a single center in Wuhan city, China. Liver Int. 2020;40(9):2095-2103. doi:10.1111/liv.14455