İKİZLERDE İKİNCİ BEBEK OLMAK PREMATÜRE MORBİDİTE VE MORTALİTESİNİ NASIL ETKİLER?

Year 2022, , 325 - 330, 31.08.2022

Duran Yıldız , Ufuk Çakır , Ali Ulaş Tuğcu , Cüneyt Tayman

https://doi.org/10.24938/kutfd.1081780

Cited By: 1

Abstract

Amaç: İkinci doğan ikiz bebeğin birinci bebeğe göre morbidite ve mortalite açısından riskleri konusunda yeterli kanıt yoktur. Çalışmamızda ilk ve ikinci doğan prematüre ikizler arasındaki mortalite ve morbidite risklerinin doğum sırasına göre belirlenmesi amaçlanmıştır.

Gereç ve Yöntemler: Çalışmaya gebelik haftası <30 hafta doğan tüm prematüre ikiz bebekler dahil edildi. Birinci ve ikinci sırada doğan ikiz bebeklerin demografik özellikleri, morbidite ve mortalite verileri karşılaştırıldı.

Bulgular: Çalışmaya gebelik haftası <30 hafta doğan 128 ikiz prematüre bebek dahil edildi. Birinci sırada doğan grupta 64 ve ikinci sırada doğan grupta 64 hasta olarak hastalar iki gruba ayrıldı. İkinci doğan bebeklerde birinci doğan bebeklere oranla respiratuvar distres sendromu, mortalite sıklığı, non invaziv ventilasyon ve yenidoğan yoğun bakım ünitesinde yatış süreleri istatistiksel olarak anlamlı yüksek bulundu (sırasıyla, p=0.024; 0.032; 0.035; 0.023).

Sonuç: Çalışmamızda ikinci sırada doğan ikiz prematüre bebeklerin respiratuvar distres sendromu, non invaziv ventilasyon destek süresi, yenidoğan yoğun bakım ünitesi yatış süresi ve mortalite açısından ilk doğan bebeklere göre daha yüksek riskli olduğu bulundu.

Keywords

prematüre, morbidite, mortalite, ilk ikiz, ikinci ikiz

Supporting Institution

yok

Project Number

yok

Thanks

yok

How Does Being Second Infant in Twins Affect Premature Morbidity and Mortality?

Abstract

Objective: There is insufficient evidence regarding the risks of morbidity and mortality in the second born twin infant compared to the first infant. In our study, it was aimed to determine the mortality and morbidity rates between first and second born premature twins.

Material and Methods: All premature and twin infants born at <30 weeks of gestation were included in the study. Demographic characteristics, morbidity and mortality of the first and second twin infants were compared.

Results: One hundred and twenty-eight twin premature infants born at <30 weeks of gestation were included in the study. The patients were divided into two groups as 64 patients in the first-born group and 64 patients in the second-born group. The frequency of respiratory distress syndrome, mortality, the length of stay in non-invasive ventilation and neonatal intensive care unit were found to be statistically significantly higher in second-born infants compared to first-born infants (p=0.024; 0.032; 0.035; 0.023, respectively).

Conclusion: In our study, it was found that the second-born twin premature infant was at higher risk than the first-born infant in terms of respiratory distress syndrome, non-invasive ventilation support time, neonatal intensive care unit hospitalization time, and mortality.

Keywords

premature, morbidity, mortality, first twin, second twin

Project Number

yok

References

• 1. Kılıç M, Aygün C, Kaynar Tunçel E, Küçüködük Ş. İkiz eşlerinin doğum ağırlıklarındaki diskordans morbidite ve mortalite açısından risk oluşturur mu? Çocuk Sağlığı ve Hastalıkları Dergisi. 2006;49(4):275-82.
• 2. Rajoria L, Meena S, Mendiratta S, Sharma A, Meena M. Neonatal death and morbidity in second twins according to mode of delivery and birth weight. IJMSDR. 2019;3(1):101-5.
• 3. Sheay W, Ananth CV, Kinzler WL. Perinatal mortality in first- and second-born twins in the United States. Obstet Gynecol. 2004;103(1):63-70.
• 4. Wen SW, Fung Kee Fung K, Oppenheimer L, Demissie K, Yang Q, Walker M. Neonatal mortality in second twin according to cause of death, gestational age, and mode of delivery. Am J Obstet Gynecol. 2004;191(3):778-83.
• 5. Rossi AC, Mullin PM, Chmait RH. Neonatal outcomes of twins according to birth order, presentation and mode of delivery: a systematic review and meta-analysis. BJOG. 2011;118(5):523-32.
• 6. Kim H, Kim J, Ko SY, Shin SM, Lee YK. Neonatal respiratory morbidity in twins according to birth order and mode of delivery. Perinatology. 2018;29(4):159-64.
• 7. Schmitz T, Carnavalet Cde C, Azria E, Lopez E, Cabrol D, Goffinet F. Neonatal outcomes of twin pregnancy according to the planned mode of delivery. Obstet Gynecol. 2008;111(3):695-703.
• 8. MacKay AP, Berg CJ, King JC, Duran C, Chang J. Pregnancy-related mortality among women with multifetal pregnancies. Obstet Gynecol. 2006;107(3):563-8.
• 9. Usta IM, Nassar AH, Awwad JT, Nakad TI, Khalil AM, Karam KS. Comparison of the perinatal morbidity and mortality of the presenting twin and its co-twin. J Perinatol. 2002;22(5):391-6.
• 10. Sibony O, Touitou S, Luton D, Oury JF, Blot PH. A comparison of the neonatal morbidity of second twins to that of a low-risk population. Eur J Obstet Gynecol Reprod Biol. 2003;108(2):157-63.
• 11. Armson BA, O'Connell C, Persad V, Joseph KS, Young DC, Baskett TF. Determinants of perinatal mortality and serious neonatal morbidity in the second twin. Obstet Gynecol. 2006;108(3 Pt 1):556-64.
• 12. Zhang J, Mikolajczyk R, Lei X, Sun L, Yu H, Cheng W. An adjustable fetal weight standard for twins: a statistical modeling study. BMC Med. 2015;13(7):159.
• 13. Cakir U, Tayman C, Buyuktiryaki M. An unknown risk factor for sepsis in very low birth weight preterms: ABO Blood Groups (BGaPS Study). Am J Perinatol. 2021;38(7):669-75.
• 14. Bozkaya D, Dizdar EA, Korkut S, Ceran B, Alkan M, Oğuz ŞS. Evaluation of different types of natural surfactants by lung ultrasound in respiratory distress syndrome. Am J Perinatol. 2021;38(6):590-6.
• 15. Cakir U, Tayman C, Karacaglar NB, Beser E, Ceran B, Unsal H. Comparison of the effect of continuous and standard intermittent bolus paracetamol infusion on patent ductus arteriosus. Eur J Pediatr. 2021;180(2):433-40.
• 16. Bozkaya D, Ceran B, Ozmen E, Okman E, Alyamac Dizdar E, Oguz SS et al. A New Hope in the Treatment of Intraventricular Haemorrhage in Preterm Infants: Mesenchymal Stem Cells. Turk Neurosurg. 2022;32(2):344-6.
• 17. Cakir U, Tayman C, Yucel C, Ozdemir O. Can IL-33 and Endocan be new markers for retinopathy of prematurity? Comb Chem High Throughput Screen. 2019;22(1):41-8.
• 18. Cakir U, Tayman C, Yarci E, Halil H, Buyuktiryaki M, Ulu HO et al. Novel useful markers for follow-up of necrotizing enterocolitis: endocan and interleukin-33. J Matern Fetal Neonatal Med. 2020;33(14):2333-41.
• 19. Cakir U, Tayman C, Yucel C. A novel diagnostic marker for the severity of bronchopulmonary dysplasia in very low birth weight ınfants: Interleukin-33. Pediatr Allergy Immunol Pulmonol. 2019;32(1):12-7.
• 20. Ceran B, Alyamaç Dizdar E, Beşer E, Karaçağlar NB, Sarı FN. Diagnostic role of systemic inflammatory indices in infants with moderate-to-severe hypoxic ischemic encephalopathy. Am J Perinatol. Am J Perinatol. 2022; 39(11): 1033-39.
• 21. Hogle KL, Hutton EK, McBrien KA, Barrett JF, Hannah ME. Cesarean delivery for twins: a systematic review and meta-analysis. Am J Obstet Gynecol. 2003;188(1):220-7.