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GEBELİKTE GEÇİRİLEN COVİD-19 ENFEKSİYONUNUN NEONATAL MORBİDİTELER VE MORTALİTE ÜZERİNE ETKİSİ

Year 2023, , 70 - 75, 30.04.2023
https://doi.org/10.24938/kutfd.1224943

Abstract

Amaç: Çin’in Wuhan kentinde ortaya çıkan COVID-19 pandemisi, dünyada 670 milyondan fazla insanı etkilemiştir. Her yaş grubunda görülen hastalığın mortalite ve morbiditesi özellikle yaşlı nüfus, kronik hastalığı olanlar ve gebelerde daha fazla gözlemlenmiştir. Bu çalışmanın amacı, pandemi sürecinde hastanemizde takip edilen ve doğum yapan, gebeliğinde COVID-19 enfeksiyonu geçirmiş gebelerin maternal ve neonatal sonuçlarını-morbiditelerini incelemek ve COVID-19 geçirmemiş gebelerin sonuçları ile karşılaştırmaktır.

Gereç ve Yöntemler: Hastanemizde Nisan 2020-Haziran 2021 tarihleri arasında izlenen ve çalışma şartlarını sağlayan gebelerin ve bebeklerin maternal-neonatal verileri dosya kayıtlarından alınarak, gebelikte COVID-19 enfeksiyonu geçiren ve geçirmeyen gebeler ve bebeklerinden oluşan ikili gruplar karşılaştırıldı.

Bulgular: Çalışmaya 2164 anne ve bebek çifti dahil edildi. Gebeliğinde COVID-19 geçirmiş (n=66) ve geçirmemiş olan anneler (n=2098) ve bebekleri arasında anne yaşı, doğum şekli, doğum ağırlığı, doğum haftası, cinsiyet, APGAR skorları, yenidoğan yoğun bakım ünitesinde yatma süreleri bakımından anlamlı fark saptanmadı.

Sonuç: Çalışma sonuçlarımız henüz etiyopatogenezi yeterince aydınlatılamamış olan COVID-19 enfeksiyonunun, maternal-neonatal risk ve hastalıkların üzerine etkisinin halen tam olarak bilinmediği görüşünü desteklemektedir.

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References

  • World Health Organization. Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. https://www.who.int/dg/speeches/ detail/who-director-general-s-remarks-at-the-mediabriefing-on-2019-ncov-on-11-february-2020 (12- 03-2020)
  • Ellington S, Strid P, Tong VT, Woodworth K, Galang RR, Zambrano LD, et al. Characteristics of Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status - United States, January 22-June 7, 2020. MMWR Morb Mortal Wkly Rep. 2020;26;69(25) :769-75.
  • Wang S, Guo L, Chen L, Liu W, Cao Y, et al. A case report of neonatal COVID-19 infection in China. Clin Infect Dis. 2020;71(15):853-7.
  • Vlachodimitropoulou Koumoutsea E, Vivanti AJ, Shehata N, et al. COVID-19 and acute coagulopathy in pregnancy. J Thromb Haemost. 2020;18(7): 164852.
  • Metz TD., Clifton RG. Hughes BL. Sandoval G, Saade GR, Grobman WA et al; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19). Obstet Gynecol. 2021;137(4):571-80.
  • Villar J, Ariff S, Gunier RB, Thiruvengadam R, Rauch S, Kholin A et al. Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 infection: the INTERCOVID multinational cohort study. JAMA Pediatr. 2021;175(8):817-26
  • Prochaska E, Jang M, Burd I. COVID-19 in pregnancy: Placental and neonatal involvement. Am J Reprod Immunol. 2020;84(5):e13306.
  • Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies. Acta Obstet Gynecol Scand. 2020; 99(7):823-29.
  • Shu L, Niu C, Li R, Huang T, Wang Y, Huang M, et al. Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells. Stem Cell Res Ther. 2020;11(1):361.
  • Vivanti AJ, Vauloup-Fellous C, Prevot S, Zupan V, Suffee C, Do Cao J et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun. 2020;11(1):3572
  • Akin IM, Kanburoglu MK, Tayman C, Oncel MY, Imdadoglu T, Dilek M et al. Neo-Covid Study Group. Epidemiologic and clinical characteristics of neonates with late-onset COVID-19: 1-year data of Turkish Neonatal Society. Eur J Pediatr. 2022;181(5):1933-42.
  • Angelidou A, Sullivan K, Melvin PR, Shui JE, Goldfarb IT, Bartolome R et al. Association of Maternal Perinatal SARS-CoV-2 Infection With Neonatal Outcomes During the COVID-19 Pandemic in Massachusetts. JAMA Netw Open. 2021;4(4):e217523. 
  • Galang RR, Newton SM, Woodworth KR, Griffin I, Oduyebo T, Sancken CL et al. Risk factors for illness severity among pregnant women with confirmed SARS-CoV-2 infection—Surveillance for Emerging Threats to Mothers and Babies Network, 22 state, local, and territorial health departments. Clin Infect Dis. 2021;73(Suppl 1): S17–23.
  • Melekoglu NA, Ozdemir H, Yasar S. Neonatal Outcomes of Pregnant Women With Confirmed Coronavirus Disease 2019: One-Year Experience of a Tertiary Care Center. Clin Pediatr (Phila). 2022;61(2):177-83.
  • Sunder A, Varghese B, Darwish B, Shaikho N, Rashid M. Impacts and effects of COVID-19 infection in pregnancy. Saudi Med J. 2022;43(1):67-74.
  • Gurol-Urganci I, Jardine JE, Carroll F, Draycott T, Dunn G, Fremeaux A, et al. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection at the time of birth in England: national cohort study. Am J Obstet Gynecol. 2021;225(5):522.e1-522.e11.

The Effect of COVID-19 Infection During Pregnancy on Neonatal Morbidities and Mortality

Year 2023, , 70 - 75, 30.04.2023
https://doi.org/10.24938/kutfd.1224943

Abstract

Objective: The COVID-19 pandemic, which emerged in Wuhan, China has affected more than 670 million people in the world. The mortality and morbidity of Coronavirus which is seen in all age groups, has been observed more especially in the elderly population, those with chronic diseases and pregnant women. The aim of this study is to examine the morbidity and the maternal-neonatal outcomes of COVID-19 infection during pregnancy.

Material and Methods: The maternal-neonatal data of the pregnant women and babies who met the study critera and were followed up in our hospital between April 2020 and June 2021, were obtained from file records. The dual groups of pregnant women who had and did not have COVID-19 infection during pregnancy and their babies were compared.

Results: A total of 2164 mother and infant couples were included in the study. No significant difference was found between mothers who had COVID-19 during pregnancy (n=66) and mothers who did not (n=2098) and their babies in terms of maternal age, delivery type, birth weight, birth week, gender, APGAR scores, and length of stay in the neonatal intensive care unit.

Conclusion: The results of our study is consistent with the idea that the effect of maternal COVID-19 infection on maternal-neonatal risk and diseases, is still unknown.

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References

  • World Health Organization. Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. https://www.who.int/dg/speeches/ detail/who-director-general-s-remarks-at-the-mediabriefing-on-2019-ncov-on-11-february-2020 (12- 03-2020)
  • Ellington S, Strid P, Tong VT, Woodworth K, Galang RR, Zambrano LD, et al. Characteristics of Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status - United States, January 22-June 7, 2020. MMWR Morb Mortal Wkly Rep. 2020;26;69(25) :769-75.
  • Wang S, Guo L, Chen L, Liu W, Cao Y, et al. A case report of neonatal COVID-19 infection in China. Clin Infect Dis. 2020;71(15):853-7.
  • Vlachodimitropoulou Koumoutsea E, Vivanti AJ, Shehata N, et al. COVID-19 and acute coagulopathy in pregnancy. J Thromb Haemost. 2020;18(7): 164852.
  • Metz TD., Clifton RG. Hughes BL. Sandoval G, Saade GR, Grobman WA et al; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19). Obstet Gynecol. 2021;137(4):571-80.
  • Villar J, Ariff S, Gunier RB, Thiruvengadam R, Rauch S, Kholin A et al. Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 infection: the INTERCOVID multinational cohort study. JAMA Pediatr. 2021;175(8):817-26
  • Prochaska E, Jang M, Burd I. COVID-19 in pregnancy: Placental and neonatal involvement. Am J Reprod Immunol. 2020;84(5):e13306.
  • Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies. Acta Obstet Gynecol Scand. 2020; 99(7):823-29.
  • Shu L, Niu C, Li R, Huang T, Wang Y, Huang M, et al. Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells. Stem Cell Res Ther. 2020;11(1):361.
  • Vivanti AJ, Vauloup-Fellous C, Prevot S, Zupan V, Suffee C, Do Cao J et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun. 2020;11(1):3572
  • Akin IM, Kanburoglu MK, Tayman C, Oncel MY, Imdadoglu T, Dilek M et al. Neo-Covid Study Group. Epidemiologic and clinical characteristics of neonates with late-onset COVID-19: 1-year data of Turkish Neonatal Society. Eur J Pediatr. 2022;181(5):1933-42.
  • Angelidou A, Sullivan K, Melvin PR, Shui JE, Goldfarb IT, Bartolome R et al. Association of Maternal Perinatal SARS-CoV-2 Infection With Neonatal Outcomes During the COVID-19 Pandemic in Massachusetts. JAMA Netw Open. 2021;4(4):e217523. 
  • Galang RR, Newton SM, Woodworth KR, Griffin I, Oduyebo T, Sancken CL et al. Risk factors for illness severity among pregnant women with confirmed SARS-CoV-2 infection—Surveillance for Emerging Threats to Mothers and Babies Network, 22 state, local, and territorial health departments. Clin Infect Dis. 2021;73(Suppl 1): S17–23.
  • Melekoglu NA, Ozdemir H, Yasar S. Neonatal Outcomes of Pregnant Women With Confirmed Coronavirus Disease 2019: One-Year Experience of a Tertiary Care Center. Clin Pediatr (Phila). 2022;61(2):177-83.
  • Sunder A, Varghese B, Darwish B, Shaikho N, Rashid M. Impacts and effects of COVID-19 infection in pregnancy. Saudi Med J. 2022;43(1):67-74.
  • Gurol-Urganci I, Jardine JE, Carroll F, Draycott T, Dunn G, Fremeaux A, et al. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection at the time of birth in England: national cohort study. Am J Obstet Gynecol. 2021;225(5):522.e1-522.e11.
There are 16 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Özgün Araştırma
Authors

Ümit Ayşe Tandırcıoğlu 0000-0002-1743-8194

Özge Doğan 0000-0002-4170-1263

Pelin Pelit 0000-0002-8515-9445

Murat Cagan 0000-0003-0629-4401

Sanem Özcan 0000-0001-5964-5215

Özgür Özyüncü 0000-0003-3256-5762

Şule Yiğit 0000-0002-8755-0384

Tolga Çelik 0000-0002-1725-0722

Project Number yok
Early Pub Date April 30, 2023
Publication Date April 30, 2023
Submission Date December 27, 2022
Published in Issue Year 2023

Cite

APA Tandırcıoğlu, Ü. A., Doğan, Ö., Pelit, P., Cagan, M., et al. (2023). GEBELİKTE GEÇİRİLEN COVİD-19 ENFEKSİYONUNUN NEONATAL MORBİDİTELER VE MORTALİTE ÜZERİNE ETKİSİ. The Journal of Kırıkkale University Faculty of Medicine, 25(1), 70-75. https://doi.org/10.24938/kutfd.1224943
AMA Tandırcıoğlu ÜA, Doğan Ö, Pelit P, Cagan M, Özcan S, Özyüncü Ö, Yiğit Ş, Çelik T. GEBELİKTE GEÇİRİLEN COVİD-19 ENFEKSİYONUNUN NEONATAL MORBİDİTELER VE MORTALİTE ÜZERİNE ETKİSİ. Kırıkkale Üni Tıp Derg. April 2023;25(1):70-75. doi:10.24938/kutfd.1224943
Chicago Tandırcıoğlu, Ümit Ayşe, Özge Doğan, Pelin Pelit, Murat Cagan, Sanem Özcan, Özgür Özyüncü, Şule Yiğit, and Tolga Çelik. “GEBELİKTE GEÇİRİLEN COVİD-19 ENFEKSİYONUNUN NEONATAL MORBİDİTELER VE MORTALİTE ÜZERİNE ETKİSİ”. The Journal of Kırıkkale University Faculty of Medicine 25, no. 1 (April 2023): 70-75. https://doi.org/10.24938/kutfd.1224943.
EndNote Tandırcıoğlu ÜA, Doğan Ö, Pelit P, Cagan M, Özcan S, Özyüncü Ö, Yiğit Ş, Çelik T (April 1, 2023) GEBELİKTE GEÇİRİLEN COVİD-19 ENFEKSİYONUNUN NEONATAL MORBİDİTELER VE MORTALİTE ÜZERİNE ETKİSİ. The Journal of Kırıkkale University Faculty of Medicine 25 1 70–75.
IEEE Ü. A. Tandırcıoğlu, Ö. Doğan, P. Pelit, M. Cagan, S. Özcan, Ö. Özyüncü, Ş. Yiğit, and T. Çelik, “GEBELİKTE GEÇİRİLEN COVİD-19 ENFEKSİYONUNUN NEONATAL MORBİDİTELER VE MORTALİTE ÜZERİNE ETKİSİ”, Kırıkkale Üni Tıp Derg, vol. 25, no. 1, pp. 70–75, 2023, doi: 10.24938/kutfd.1224943.
ISNAD Tandırcıoğlu, Ümit Ayşe et al. “GEBELİKTE GEÇİRİLEN COVİD-19 ENFEKSİYONUNUN NEONATAL MORBİDİTELER VE MORTALİTE ÜZERİNE ETKİSİ”. The Journal of Kırıkkale University Faculty of Medicine 25/1 (April 2023), 70-75. https://doi.org/10.24938/kutfd.1224943.
JAMA Tandırcıoğlu ÜA, Doğan Ö, Pelit P, Cagan M, Özcan S, Özyüncü Ö, Yiğit Ş, Çelik T. GEBELİKTE GEÇİRİLEN COVİD-19 ENFEKSİYONUNUN NEONATAL MORBİDİTELER VE MORTALİTE ÜZERİNE ETKİSİ. Kırıkkale Üni Tıp Derg. 2023;25:70–75.
MLA Tandırcıoğlu, Ümit Ayşe et al. “GEBELİKTE GEÇİRİLEN COVİD-19 ENFEKSİYONUNUN NEONATAL MORBİDİTELER VE MORTALİTE ÜZERİNE ETKİSİ”. The Journal of Kırıkkale University Faculty of Medicine, vol. 25, no. 1, 2023, pp. 70-75, doi:10.24938/kutfd.1224943.
Vancouver Tandırcıoğlu ÜA, Doğan Ö, Pelit P, Cagan M, Özcan S, Özyüncü Ö, Yiğit Ş, Çelik T. GEBELİKTE GEÇİRİLEN COVİD-19 ENFEKSİYONUNUN NEONATAL MORBİDİTELER VE MORTALİTE ÜZERİNE ETKİSİ. Kırıkkale Üni Tıp Derg. 2023;25(1):70-5.

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