Romatoid Faktör ve Anti Siklik Sitrülin Peptid Antikor Testlerinin Romatoid Artrit Tanı ve Takibindeki Önemi

Year 2015, , 29 - 33, 05.01.2016

Turgut Kültür

https://doi.org/10.24938/kutfd.124927

Cited By: 1

Abstract

Romatoid artrit simetrik erozif sinovitlerle karekterize, etiyolojisi tam aydınlatılamamış kronik, otoimmün bir hastalıktır. Romatoid artritte özgün bir tanı testi bulunmasa da çeşitli laboratuvar testleri erken tanı ve takip ve prognozun saptanmasında faydalıdırlar. Romatoid artrit hastalarının poliartritlerden ayırımında Romatoid Faktörler (RF) önemli bir role sahiptirler. Ancak çoğu güncel tanı kılavuzunda RF’nin önemi hala vurgulansa da artık anti   -cycliccitrullinated peptid antikor testleri, RF’ den daha öncelikli hal almaya başlamıştır.

Keywords

Romatoid artrit, laboratuar bulguları, Romatoid Faktör, anti-siklik sitrülin peptid antikor

References

• Ingegnoli F, Castelli R, Gualtierotti R. Rheumatoid factors: clinical applications. Dis Markers. 2013; 35, 727-34.
• Aletaha D, Alasti F Smolen JS. Rheumatoid factor determines structural progression of rheumatoid arthritis dependent and independent of disease activity. Ann Rheum Dis. 2013; 72: 875-80.
• Nell V, Machold K, Stamm T, Eberl G, Heinzl H, Uffmann M, Smolen J, Steiner G. Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis. Ann Rheum Dis. 2005; 64: 1731-36.
• Swedler W, Wallman J, Froelich CJ, Teodorescu M. Routine measurement of IgM, IgG, and IgA rheumatoid factors: high sensitivity, specificity, and predictive value for rheumatoid arthritis. J Rheumatol. 1997; 24: 1037-44.
• Sweet RA, Cullen JL, Shlomchik MJ. Rheumatoid factor B cell memory leads to rapid, switched antibody-forming cell responses. J Immunol. 2013; 190(5): 1974-81.
• Jonsson T, Valdimarsson H. What about IgA rheumatoid factor in rheumatoid arthritis? Ann Rheum Dis. 1998; 57(1): 63-4.
• Jonsson T, Steinsson K, Jonsson H, Geirsson AJ, Thorsteinsson J, Valdimarsson H. Combined elevation of IgM and IgA rheumatoid factor has high diagnostic specificity for rheumatoid arthritis. Rheumatol Int. 1998; 18: 119-22.
• Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988; 31: 315-24.
• Halldorsdottir HD, Jonsson T, Thorsteinsson J, Valdimarsson H. A prospective study on the incidence of rheumatoid arthritis among people with persistent increase of rheumatoid factor. Ann Rheum Dis. 2000; 59: 149-51.
• Majka DS, Deane KD, Parrish LA, Lazar AA, Baron AE, Walker CW, Rubertone MV, Gilliland WR, Norris JM, Holers VM. Duration of preclinical rheumatoid arthritis-related autoantibody positivity increases in subjects with older age at time of disease diagnosis. Ann Rheum Dis. 2008; 67: 801-7.
• Nielen MM, van Schaardenburg D, Reesink HW, van de Stadt RJ, van der Horst-Bruinsma IE, de Koning MH, Habibuw MR, Vandenbroucke JP, Dijkmans BA. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum. 2004; 50(2): 380-6.
• Barra L, Bykerk V, Pope JE, Haraoui BP, Hitchon CA, Thorne JC, Keystone EC, Boire G, Catch Investigators. Anticitrullinated protein antibodies and rheumatoid factor fluctuate in early inflammatory arthritis and do not predict clinical outcomes. J Rheumatol. 2013; 40: 1259-67.
• Tillmann T, Krishnadas R, Cavanagh J, Petrides K. Possible rheumatoid arthritis subtypes in terms of rheumatoid factor, depression, diagnostic delay and emotional expression: an exploratory case-control study. Arthritis Res Ther. 2013; 15: R45.
• Scutellari PN, Orzincolo C. Rheumatoid arthritis sequences. Eur J Radiol. 1998; 1: S31-8.
• Newkirk MM. Rheumatoid Factors: What do they tell us? J Rheumatol. 2002: 29(10): 2034-40.
• 16.Bajocchi G, La Corte R, Locaputo A, Govoni M, Trotta F. Elderly onset rheumatoid arthritis: clinical aspects. Clin Exp Rheumatol. 2000; 18(Suppl 20): 49-50.
• Deal CL, Meenan RF, Goldenberg DL, Anderson JJ, Sack B, Pastan RS, Cohen AS. The clinical features of elderly -onset rheumatoid arthritis. A comparison with younger-onset disease of similar duration. Arthritis Rheum. 1985; 28(9): 987-94.
• Turkcapar N, Demir O, Atli T, Kopuk M, Turgay M, Kinikli G, Duman M. Late onset rheumatoid arthritis: clinical and laboratory comparisons with younger onset patients. Arch Gerontol Geriatr. 2006; 42(2): 225-31.
• -
• Inoue K, Shichikawa K, Nishioka J, Hirota S. Older age onset rheumatoid arthritis with or without osteoarthritis. Ann Rheum Dis. 1987; 46: 908-11.
• Dresser DW, Popham AM. Induction of an IgM anti-(bovine)-IgG response in mice by bacterial lipopolysaccharide. Nature. 1976; 264: 552-4.
• Newkirk, M.M. Rheumatoid factors: host resistance or autoimmunity? Clin Immunol Orlando Fla. 2002; 104: 1 -13.
• Charles ED, Orloff MIM, Nishiuchi E, Marukian S, Rice CM, Dustin LB. Somatic hypermutations confer rheumatoid factor activity in hepatitis C virus-associated mixed cryoglobulinemia. Arthritis Rheum. 2013; 65; 2430-40.
• Palazzi C, Buskila D, D’Angelo S, D’Amico E, Olivieri I. Autoantibodies in patients with chronic hepatitis C virus infection: pitfalls for the diagnosis of rheumatic diseases. Autoimmun. Rev. 2012; 11: 659-63.
• Díaz-López C, Geli C, Corominas H, Malat N, Diaz-Torner C, Llobet JM, De La Serna AR, Laiz A, Moreno M, Vázquez G. Are there clinical or serological differences between male and female patients with primary Sjögren’s syndrome? J Rheumatol. 2004; 31: 1352-5.
• Schwarz MI. Pulmonary Manifestations of the Collagen Vasculer Diseases. In: Fishman AP, Elias JA, Grippi MA (Eds). Fishman’s Pulmonary Diseases AndDisordesVol 1, 13thed. New York: The Mc Grow Hill Co., 1998:1122-6.
• Chibnik LB, Mandl LA, Costenbader KH, Schur PH, Karlson EW. Comparison of threshold cutpoints and continuous measures of anti-cyclic citrullinated peptide antibodies in predicting future rheumatoid arthritis. J Rheumatol. 2009; 36: 706-11.
• Kolfenbach JR, Deane KD, Derber LA, O’Donnell CI, Gilliland WR, Edison JD, Rosen A, Darrah E, Norris JM, Holers VM. Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis. Arthritis Rheum. 2010; 62: 2633-9.
• Shi J, van de Stadt LA, Levarht EWN, Huizinga TWJ, Toes REM, Trouw LA, van Schaardenburg D. Anti-carbamylated protein antibodies are present in arthralgia patients and predict the development of rheumatoid arthritis. Arthritis Rheum. 2013; 65: 911-5.
• Turesson C, Bergström U, Jacobsson LTH, Truedsson L, Berglund G, Saxne T. Increased cartilage turnover and circulating autoantibodies in different subsets before the clinical onset of rheumatoid arthritis. Ann Rheum Dis. 2011; 70: 520-2.
• Van Venrooij WJ, van Beers JJBC, Pruijn GJM. Anti-CCP Antibody, a Marker for the Early Detection of Rheumatoid Arthritis. Ann N Y Acad Sci. 2008; 1143: 268-85.
• Klareskog L, Widhe M, Hermansson M, Rönnelid J. Antibodies to citrullinated proteins in arthritis: pathology and promise. Curr Opin Rheumatol. 2008; 20: 300-5.
• Bizzaro N, Bartoloni E, Morozzi G, Manganelli S, Riccieri V, Sabatini P, Filippini M, Tampoia M, Afeltra A, Sebastiani G. Anti-cyclic citrullinated peptide antibody titer predicts time to rheumatoid arthritis onset in patients with undifferentiated arthritis: results from a 2-year prospective study. Arthritis Res Ther. 2013; 15: R16.
• Rantapää-Dahlqvist S, de Jong BAW, Berglin E, Hallmans G, Wadell G, Stenlund H, Sundin U, van Venrooij WJ. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003; 48: 2741-9.
• Syversen SW, Goll GL, van der Heijde D, Landewé R, Lie BA, Odegård S, Uhlig T, Gaarder PI, Kvien TK. Prediction of radiographic progression in rheumatoid arthritis and the role of antibodies against mutated citrullinatedvimentin: results from a 10-year prospective study. Ann Rheum Dis. 2010; 69: 345-51.
• Palosuo T, Tilvis R, Strandberg T, Aho K. Filaggrin related antibodies among the aged. Ann Rheum Dis. 2003; 62: 261-3.
• Olivieri I, Palazzi C, Peruz G, Padula A. Management issues with elderly-onset rheumatoid arthritis: an update. Drugs Aging. 2005; 22: 809-22.
• Marengo MF, Suarez-Almazor ME, Lu H. Neoplastic and paraneoplastic synovitis. Rheum Dis Clin North Am. 2011; 37: 551-72.