Case Report

LATE-ONSET NEVUS COMEDONICUS IN AN ADULT PATIENT WITH DIABETES MELLITUS

Volume: 27 Number: 2 August 25, 2025
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LATE-ONSET NEVUS COMEDONICUS IN AN ADULT PATIENT WITH DIABETES MELLITUS

Abstract

Nevus comedonicus (NC) is classically defined as a malformation of the pilosebaceous unit characterized by dilated follicular ostia and comedone-like hyperkeratotic follicular plugs. In addition to the classical type, inflammatory NC (NC suppurativa) is accompanied by inflammatory lesions and has been rarely reported in the literature. We report a case of late-onset NC suppurativa on the midline of the forehead in a 47-year-old male patient with diabetes mellitus (DM). Skeletal, central nervous system, dental, and ophthalmologic examinations for NC syndrome were normal. The coexistence of NC suppurativa and DM may not be incidental. Regular monitoring of patients with NC suppurativa for signs of DM could be beneficial. Future studies should include diagnostic tests for DM in all patients with NC suppurativa to clarify the potential link with DM.

Keywords

References

  1. Sharma S, Sahu P, Dayal S, Yadav A, Brar K. Nevus comedonicus suppurativa: A report of a novel entity. J Clin Aesthet Dermatol. 2020;13(6):36-39.
  2. Zanniello R, Pilloni L, Conti B, Faa G, Rongioletti F. Late-onset nevus comedonicus with follicular epidermolytic hyperkeratosis-case report and review of the literature. Am J Dermatopathol. 2019;41(6):453-455.
  3. Grimalt R, Caputo R. Posttraumatic nevus comedonicus. J Am Acad Dermatol. 1993;28(2 Pt 1):273-274.
  4. Levinsohn JL, Sugarman JL; Yale Center for Mendelian Genomics; McNiff JM, Antaya RJ, Choate KA. Somatic mutations in NEK9 cause nevus comedonicus. Am J Hum Genet. 2016;98(5):1030-1037.
  5. Liu F, Yang Y, Zheng Y, Liang YH, Zeng K. Mutation and expression of ABCA12 in keratosis pilaris and nevus comedonicus. Mol Med Rep. 2018;18(3):3153-3158.
  6. Melnik B, Schmitz G. FGFR2 signaling and the pathogenesis of acne. J Dtsch Dermatol Ges. 2008;6(9):721-728.
  7. Mazzella C, Fabbrocini G, Luciano MA, Cacciapuoti S. Nevus comedonicus with acne vulgaris and obesity. Dermatol Pract Concept. 2019;10(1):e2020006.
  8. Laplante M, Sabatini DM. mTOR signaling at a glance. J Cell Sci. 2009;122(Pt 20):3589-3594.

Details

Primary Language

English

Subjects

Health Services and Systems (Other)

Journal Section

Case Report

Publication Date

August 25, 2025

Submission Date

December 30, 2024

Acceptance Date

April 11, 2025

Published in Issue

Year 2025 Volume: 27 Number: 2

APA
Özaslan, M., & Çelik, Z. (2025). LATE-ONSET NEVUS COMEDONICUS IN AN ADULT PATIENT WITH DIABETES MELLITUS. The Journal of Kırıkkale University Faculty of Medicine, 27(2), 246-249. https://doi.org/10.24938/kutfd.1609752
AMA
1.Özaslan M, Çelik Z. LATE-ONSET NEVUS COMEDONICUS IN AN ADULT PATIENT WITH DIABETES MELLITUS. Kırıkkale Uni Med J. 2025;27(2):246-249. doi:10.24938/kutfd.1609752
Chicago
Özaslan, Metin, and Zeliha Çelik. 2025. “LATE-ONSET NEVUS COMEDONICUS IN AN ADULT PATIENT WITH DIABETES MELLITUS”. The Journal of Kırıkkale University Faculty of Medicine 27 (2): 246-49. https://doi.org/10.24938/kutfd.1609752.
EndNote
Özaslan M, Çelik Z (August 1, 2025) LATE-ONSET NEVUS COMEDONICUS IN AN ADULT PATIENT WITH DIABETES MELLITUS. The Journal of Kırıkkale University Faculty of Medicine 27 2 246–249.
IEEE
[1]M. Özaslan and Z. Çelik, “LATE-ONSET NEVUS COMEDONICUS IN AN ADULT PATIENT WITH DIABETES MELLITUS”, Kırıkkale Uni Med J, vol. 27, no. 2, pp. 246–249, Aug. 2025, doi: 10.24938/kutfd.1609752.
ISNAD
Özaslan, Metin - Çelik, Zeliha. “LATE-ONSET NEVUS COMEDONICUS IN AN ADULT PATIENT WITH DIABETES MELLITUS”. The Journal of Kırıkkale University Faculty of Medicine 27/2 (August 1, 2025): 246-249. https://doi.org/10.24938/kutfd.1609752.
JAMA
1.Özaslan M, Çelik Z. LATE-ONSET NEVUS COMEDONICUS IN AN ADULT PATIENT WITH DIABETES MELLITUS. Kırıkkale Uni Med J. 2025;27:246–249.
MLA
Özaslan, Metin, and Zeliha Çelik. “LATE-ONSET NEVUS COMEDONICUS IN AN ADULT PATIENT WITH DIABETES MELLITUS”. The Journal of Kırıkkale University Faculty of Medicine, vol. 27, no. 2, Aug. 2025, pp. 246-9, doi:10.24938/kutfd.1609752.
Vancouver
1.Metin Özaslan, Zeliha Çelik. LATE-ONSET NEVUS COMEDONICUS IN AN ADULT PATIENT WITH DIABETES MELLITUS. Kırıkkale Uni Med J. 2025 Aug. 1;27(2):246-9. doi:10.24938/kutfd.1609752

This Journal is a Publication of Kırıkkale University Faculty of Medicine.