SİSPLATİN OTOTOKSİSİTESİ

Burak Taş; Gökçe Şimşek

doi:10.24938/kutfd.306905

SİSPLATİN OTOTOKSİSİTESİ

Abstract

Ototoksisite çeşitli ilaçlar ve kimyasal maddelerin koklea ve vestibüler organda oluşturduğu hücresel dejenerasyon ve fonksiyon bozukluğudur. Sisplatin (Cis-diamindiklorplatinum II) özellikle baş-boyun tümörlerinde, ürogenital sistem, santral sinir sistemi, solunum sistemi ve özefagus kanserleri olmak üzere birçok malign hastalığın tedavisinde erişkinlerde ve çocuklarda kullanılmakta olan antineoplastik bir ajandır. Sisplatinin nefrotoksisite ve geri dönüşümsüz ototoksisite dışında diğer önemli doz sınırlayıcı yan etkileri nörotoksisite, gastrointestinal sistem ve kemik iliği toksisitesidir. Sisplatin ototoksik etkisini reaktif oksijen ürünleri ve DNA hasarı ile göstermektedir. Sisplatin ototoksisitesinde klinik olarak başlangışta yüksek frekanslarda, sonrasında konuşma sesini de içeren düşük frekanslarda, bilateral, sensorinöral işitme kaybı görülür. Günümüzde sisplatin bağımlı ototoksisiteyi önlemede standart bir tedavi bulunmamaktadır. Bu derlemede sisplatin ototoksisitesinin tanımı, etki mekanizması, güncel tedavi seçenekleri güncel literatür bilgileri eşliğinde tartışılmıştır.

Keywords

Sisplatin,ototoksisite,önleme,koklea,işitme kaybı,antioksidan

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Review

Authors

Burak Taş
Kırıkkale Üniversitesi, Tıp Fakültesi, KBB Anabilim Dalı
Türkiye

Gökçe Şimşek
Kırıkkale Üniversitesi, Tıp Fakültesi, KBB Anabilim Dalı
Türkiye

Publication Date

April 24, 2017

Submission Date

April 18, 2017

Acceptance Date

April 21, 2017

Published in Issue

Year 2017 Volume: 19 Number: 1

DOI

https://doi.org/10.24938/kutfd.306905

IZ

https://izlik.org/JA52KZ29SE

Cite

RIS / Bibtex

APA

Taş, B., & Şimşek, G. (2017). SİSPLATİN OTOTOKSİSİTESİ. The Journal of Kırıkkale University Faculty of Medicine, 19(1), 30-36. https://doi.org/10.24938/kutfd.306905

AMA

1.Taş B, Şimşek G. SİSPLATİN OTOTOKSİSİTESİ. Kırıkkale Uni Med J. 2017;19(1):30-36. doi:10.24938/kutfd.306905

Chicago

Taş, Burak, and Gökçe Şimşek. 2017. “SİSPLATİN OTOTOKSİSİTESİ”. The Journal of Kırıkkale University Faculty of Medicine 19 (1): 30-36. https://doi.org/10.24938/kutfd.306905.

EndNote

Taş B, Şimşek G (April 1, 2017) SİSPLATİN OTOTOKSİSİTESİ. The Journal of Kırıkkale University Faculty of Medicine 19 1 30–36.

IEEE

[1]B. Taş and G. Şimşek, “SİSPLATİN OTOTOKSİSİTESİ”, Kırıkkale Uni Med J, vol. 19, no. 1, pp. 30–36, Apr. 2017, doi: 10.24938/kutfd.306905.

ISNAD

Taş, Burak - Şimşek, Gökçe. “SİSPLATİN OTOTOKSİSİTESİ”. The Journal of Kırıkkale University Faculty of Medicine 19/1 (April 1, 2017): 30-36. https://doi.org/10.24938/kutfd.306905.

JAMA

1.Taş B, Şimşek G. SİSPLATİN OTOTOKSİSİTESİ. Kırıkkale Uni Med J. 2017;19:30–36.

MLA

Taş, Burak, and Gökçe Şimşek. “SİSPLATİN OTOTOKSİSİTESİ”. The Journal of Kırıkkale University Faculty of Medicine, vol. 19, no. 1, Apr. 2017, pp. 30-36, doi:10.24938/kutfd.306905.

Vancouver

1.Burak Taş, Gökçe Şimşek. SİSPLATİN OTOTOKSİSİTESİ. Kırıkkale Uni Med J. 2017 Apr. 1;19(1):30-6. doi:10.24938/kutfd.306905

Cited By

Comparison of the protective efficacy between intratympanic dexamethasone and resveratrol treatments against cisplatin-induced ototoxicity: an experimental study

European Archives of Oto-Rhino-Laryngology

https://doi.org/10.1007/s00405-019-05635-x