SİSPLATİN OTOTOKSİSİTESİ

Year 2017, , 30 - 36, 24.04.2017

Burak Taş , Gökçe Şimşek

https://doi.org/10.24938/kutfd.306905

Cited By: 1

Abstract

Ototoksisite
çeşitli ilaçlar ve kimyasal maddelerin koklea ve vestibüler organda oluşturduğu
hücresel dejenerasyon ve fonksiyon bozukluğudur. Sisplatin
(Cis-diamindiklorplatinum II) özellikle baş-boyun tümörlerinde, ürogenital
sistem, santral sinir sistemi, solunum sistemi ve özefagus kanserleri olmak
üzere birçok malign hastalığın tedavisinde erişkinlerde ve çocuklarda
kullanılmakta olan antineoplastik bir ajandır. Sisplatinin nefrotoksisite ve
geri dönüşümsüz ototoksisite dışında diğer önemli doz sınırlayıcı yan etkileri nörotoksisite,
gastrointestinal sistem ve kemik iliği toksisitesidir. Sisplatin ototoksik
etkisini reaktif oksijen ürünleri ve DNA hasarı ile göstermektedir. Sisplatin
ototoksisitesinde klinik olarak başlangışta yüksek frekanslarda, sonrasında
konuşma sesini de içeren düşük frekanslarda, bilateral, sensorinöral işitme
kaybı görülür. Günümüzde sisplatin bağımlı ototoksisiteyi önlemede standart bir
tedavi bulunmamaktadır. Bu derlemede sisplatin ototoksisitesinin tanımı, etki
mekanizması, güncel tedavi seçenekleri güncel literatür bilgileri eşliğinde
tartışılmıştır.

Keywords

Sisplatin, ototoksisite, önleme, koklea, işitme kaybı, antioksidan

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