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Treatment of High Voltage Electric Shock with Amantadine

Year 2018, , 209 - 211, 31.08.2018
https://doi.org/10.24938/kutfd.365927

Abstract

High voltage electric shock injuries (HVESI) can lead to
traumatic brain injury (TBI). Amantadin is a new drug that has been widely used
for TBI. Twenty-six years old male patient developed loss of consciousness
after 32.000 volt of electric shock and was admitted to the Intensive Care Unit
with a Glasgow Coma Scale of 12. The patient had confusion-agitation and was
complaining of blurred vision. Physical examination revealed isochoric pupils
and bilateral positive light reflex. Fundus examination was normal. Cervical,
thoracal and abdominal computed tomographic imagings were reported to be normal.
However, cranial tomography revealed a subcutaneous hematom at the right
occipital field. The inlet and outlet injury hole of of the electrical shock
was localized at the palmar area and fingers at both hands. The burn injury was
2. and 3. degree with a percentage of 36 %. Fasciotomy was performed to the
left foot under emergency conditions. Aggressive fluid resuscitation and
alkaline diuresis was achieved with a maintenance of 1 ml/kg/hr urine output as
creatine phosphokinase (CPK) level reached 933 IU/L and the urine tests
revealed high density and myoglobinuria. İntravenous amantadine sulphate
treatment was initiated on the first day with a dose of 2*1. On the third day
of amantadine treatment, agitation had resolved and GCS was 15. On postoperative
6. day, the patient was transferred to the Plastic Surgery Department. As a
result, amantadine treatment should be considered in every HVESI accompanied by
TBI. Early initiation of the treatment provides neurological stability with a
fast recovery of confusion, irritability and agitation.

References

  • 1. Stelmaschuk S, Will MC, Meyers T. Amantadine to treat cognitive dysfunction in moderate to severe traumatic brain ınjury. J Trauma Nurs. 2015;22(4):194-203; quiz E1-2.
  • 2. Delgadillo D, Chapman S, Fahrenkopf MP, Martin MD. Acute-onset quadriplegia with recovery after high-voltage electrical ınjury. Ann Plast Surg. 2017;79(5):e33-e36.
  • 3. Johansen CK, Welker KM, Lindell EP, Petty GW. Cerebral corticospinal tract injury resulting from high-voltage electrical shock. AJNR. 2008;29:1142-3.
  • 4. Saniova B, Drobny M, Kneslova L, Minarik M. The outcome of patients with severe head injuries treated with amantadine sulphate. J Neurol Trans. 2004;111:511-4.
  • 5. Gramish JA, Kopp BJ, Patanwala AE. Effect of Amantadine on Agitation in Critically Ill Patients With Traumatic Brain Injury. Clin Neuropharmacol. 2017;40(5):212-6.
  • 6. Liao WC1, Lin JT. High-voltage electrical brain injury. J Trauma. 2008;64(3):843-5.

YÜKSEK VOLTAJ ELEKTRİK ÇARPMASINDA AMANTADİN TEDAVİSİ

Year 2018, , 209 - 211, 31.08.2018
https://doi.org/10.24938/kutfd.365927

Abstract



Yüksek
voltaj elektrik yaralanmaları (YVEY) travmatik beyin hasarı (TBH) ile birlikte
olabilir. Amantadin son yıllarda TBH’da sıklıkla kullanılmaktadır. 32.000
voltaj elektrik çarpması ile bilinç kaybı gelişen 26 yaşında erkek hastanın
yoğun bakıma kabulünde Glasgow Koma Skalası (GKS):12 idi. Konfüzyon-ajitasyon
ve görme bulanıklığı olan hastanın pupilleri izokorik, ışık refleksi bilateral
pozitif idi. Göz dibi muayenesinde herhangi bir patoloji saptanmadı. Servikal,
toraks ve abdomen tomografileri normal iken beyin tomografisinde sağ oksipital
bölgede cilt altı hematom mevcuttu. Her iki el palmar yüz ve parmaklarda giriş-
çıkış yerleri olan hastanın %36 oranında 2. ve 3. derece yanık mevcuttu.
Kompartman sendromu tanısı ile acil ameliyata alınarak sağ ayakta fasiyotomi
yapıldı. Kreatin fosfokinaz (CPK) değeri 933 IU/L, idrar dansitesi yüksek ve
miyoglobinürik olması üzerine agresif sıvı tedavisi ve alkali diürez
sağlanarak, 1 ml/kg/saat idrar çıkışı sağlandı. Amantadin sülfat 2x1 intravenöz
(iv) tedavisine ilk gün başlanan hastanın 3. günde hastanın ajitasyonları
düzeldi ve GKS 15 idi. Postoperatif 6. günde Plastik Cerrahi bölümüne
devredildi. Sonuç olarak TBH’nın eşlik ettiği YVEY’da amantadin standart
tedaviye eklenmesi gereken bir ajandır. Erken dönemde başlanması ile konfüzyon,
mental esneklik kaybı, irritabilite ve ajitasyonda hızlı bir şekilde düzelme
ile nörolojik stabilite sağlanabileceğini düşünmekteyiz.

References

  • 1. Stelmaschuk S, Will MC, Meyers T. Amantadine to treat cognitive dysfunction in moderate to severe traumatic brain ınjury. J Trauma Nurs. 2015;22(4):194-203; quiz E1-2.
  • 2. Delgadillo D, Chapman S, Fahrenkopf MP, Martin MD. Acute-onset quadriplegia with recovery after high-voltage electrical ınjury. Ann Plast Surg. 2017;79(5):e33-e36.
  • 3. Johansen CK, Welker KM, Lindell EP, Petty GW. Cerebral corticospinal tract injury resulting from high-voltage electrical shock. AJNR. 2008;29:1142-3.
  • 4. Saniova B, Drobny M, Kneslova L, Minarik M. The outcome of patients with severe head injuries treated with amantadine sulphate. J Neurol Trans. 2004;111:511-4.
  • 5. Gramish JA, Kopp BJ, Patanwala AE. Effect of Amantadine on Agitation in Critically Ill Patients With Traumatic Brain Injury. Clin Neuropharmacol. 2017;40(5):212-6.
  • 6. Liao WC1, Lin JT. High-voltage electrical brain injury. J Trauma. 2008;64(3):843-5.
There are 6 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Case Reports
Authors

Gülçin Aydın

Işın Gençay

Selim Çolak This is me

Publication Date August 31, 2018
Submission Date December 14, 2017
Published in Issue Year 2018

Cite

APA Aydın, G., Gençay, I., & Çolak, S. (2018). YÜKSEK VOLTAJ ELEKTRİK ÇARPMASINDA AMANTADİN TEDAVİSİ. The Journal of Kırıkkale University Faculty of Medicine, 20(2), 209-211. https://doi.org/10.24938/kutfd.365927
AMA Aydın G, Gençay I, Çolak S. YÜKSEK VOLTAJ ELEKTRİK ÇARPMASINDA AMANTADİN TEDAVİSİ. Kırıkkale Üni Tıp Derg. August 2018;20(2):209-211. doi:10.24938/kutfd.365927
Chicago Aydın, Gülçin, Işın Gençay, and Selim Çolak. “YÜKSEK VOLTAJ ELEKTRİK ÇARPMASINDA AMANTADİN TEDAVİSİ”. The Journal of Kırıkkale University Faculty of Medicine 20, no. 2 (August 2018): 209-11. https://doi.org/10.24938/kutfd.365927.
EndNote Aydın G, Gençay I, Çolak S (August 1, 2018) YÜKSEK VOLTAJ ELEKTRİK ÇARPMASINDA AMANTADİN TEDAVİSİ. The Journal of Kırıkkale University Faculty of Medicine 20 2 209–211.
IEEE G. Aydın, I. Gençay, and S. Çolak, “YÜKSEK VOLTAJ ELEKTRİK ÇARPMASINDA AMANTADİN TEDAVİSİ”, Kırıkkale Üni Tıp Derg, vol. 20, no. 2, pp. 209–211, 2018, doi: 10.24938/kutfd.365927.
ISNAD Aydın, Gülçin et al. “YÜKSEK VOLTAJ ELEKTRİK ÇARPMASINDA AMANTADİN TEDAVİSİ”. The Journal of Kırıkkale University Faculty of Medicine 20/2 (August 2018), 209-211. https://doi.org/10.24938/kutfd.365927.
JAMA Aydın G, Gençay I, Çolak S. YÜKSEK VOLTAJ ELEKTRİK ÇARPMASINDA AMANTADİN TEDAVİSİ. Kırıkkale Üni Tıp Derg. 2018;20:209–211.
MLA Aydın, Gülçin et al. “YÜKSEK VOLTAJ ELEKTRİK ÇARPMASINDA AMANTADİN TEDAVİSİ”. The Journal of Kırıkkale University Faculty of Medicine, vol. 20, no. 2, 2018, pp. 209-11, doi:10.24938/kutfd.365927.
Vancouver Aydın G, Gençay I, Çolak S. YÜKSEK VOLTAJ ELEKTRİK ÇARPMASINDA AMANTADİN TEDAVİSİ. Kırıkkale Üni Tıp Derg. 2018;20(2):209-11.

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