Angina Pektoris Nedeniyle Acile Başvuran Hastaların Tanısında Scube1’in Değeri

Abstract

Amaç: Bu çalışmanın amacı göğüs ağrısı nedeniyle acil servise başvuran hastalarda Signal peptide-CUB-EGF Domain-containing Protein 1 (SCUBE 1)’in angina pektoris tanısındaki değerini araştırmaktır.

Gereç ve Yöntemler: Bu çalışma prospektif, kesitsel, tek merkezli bir klinik çalışma olarak planlandı. Etik kurul onayının alınmasından itibaren toplam 5 ay süreyle acil servise iskemik göğüs ağrısı şikayetiyle başvuran hastalar dahil edildi. İskemik göğüs ağrısı ile başvuran hastalar etyolojilerine göre stabil angina pektoris (SAP), unstabil angina pektoris (UAP), ST elevasyonu olmayan myokard infarktüsü (NSTEMI), ST elevasyonlu myokard infarktüsü (STEMI) olmak üzere gruplara ayrıldı. Klinik, laboratuar ve demografik özellikleri kayıt altına alındı. Her bir gruptan ölçülen serum SCUBE 1 düzeyleri istatistiksel olarak analiz edilerek sağlıklı kontrol grubuyla karşılaştırılarak analiz edildi.

Bulgular: Çalışmanın dahil etme kriterlerine uygunluk gösteren 78 hasta ile 40 sağlıklı kontrol olmak üzere toplam 118 kişi çalışmaya alındı. Hastaların yaş ortalaması 54.36±14.03 olup % 88.5’i (n=69) tanesi erkekti. Hastaların risk faktörleri incelendiğinde HT(%59) ve sigara (%62) diğer risk faktörlerine göre daha ağırlıktaydı. İskemik göğüs ağrısı şikayetiyle çalışmaya dahil ettiğimiz hastalarda en sık etken NSTEMI olarak tespit edildi (%46.1). Hastaların başvuru anında, 6.saat ve 12. saat serum SCUBE-1 değerleri kontrol grubu ile karşılaştırıldığında istatiksel olarak anlamlı fark bulunmadı (p>0.05).

Sonuç: Çalışmamızın bulgularına göre SCUBE 1, iskemik göğüs ağrısı etiyolojilerinin tanısında değeri bulunmamaktadır.

Keywords

• SCUBE1,Angina pektoris

THE DIAGNOSTIC VALUE OF SCUBE1 IN PATIENTS PRESENTING TO THE EMERGENCY DEPARTMENT DUE TO ANGINA PECTORIS

Abstract

Objective: The purpose of this study was to investigate the value of signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) in the diagnosis of angina pectoris in patients presenting to the emergency department.

Material and Methods: This prospective research was planned as a cross-sectional, single-center clinical study. Patients presenting to the emergency department with angina pectoris symptoms over a period of five months from receipt of ethical committee approval were included. Patients presenting with ischemic chest pain were divided on the basis of etiology into stable angina pectoris (SAP), unstable angina pectoris (UAP), non-ST elevation myocardial infarction (NSTEMI), and ST segment elevation myocardial infarction (STEMI) groups. Clinical, laboratory and demographic characteristics were recorded. SCUBE1 levels from each group were compared with a healthy control group.

Results: 118 individuals were enrolled in the study, 78 patients meeting the inclusion criteria and 40 healthy controls. Patients’ mean age was 54.36 ± 14.03 years, and 88.5% (n=69) were male. Hypertension (59%) and smoking (62%) predomination over other risk factors. NSTEMI was the most common factor (46.1%) in patients enrolled due to ischemic chest pain. No statistically significant difference was determined between patients’ serum SCUBE1 levels at time of presentation and at 6 h and 12 h and the control group (p>0.05).

Conclusion: On the basis of our study findings, SCUBE1 is of no value in the diagnosis of ischemic chest pain etiologies. 

Keywords

• Angina pectoris,SCUBE1,acute coronary syndrome

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