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A Case of Autoimmune Polyglandular Syndrome Type 1 Presenting with Hypocalcemia

Year 2019, , 109 - 114, 30.04.2019
https://doi.org/10.24938/kutfd.426463

Abstract

Autoimmune
polyglandular syndrome type 1 is a very rare monogenic autosomal recessive
disease, defined by the presence of at least two of three major diseases:
Chronic mucocutanenous candidiasis, hypoparathyroidism and autoimmune adrenal
failure. The range of these secondary autoimmune disorder is broad and
variable. In this paper, we presented a case of autoimmune polyglandular
syndrome type 1 whose initial diagnosis was hypoparathyroidism presenting with
hypocalcemia.
A 14 year old girl presented with hypocalcemia and hypoparathyroidism at
the age of 8, and
chronic
mucocutanenous candidiasis,
thyroiditis and hypergonadotropic hypogonadism
was detected at follow-up.

Autoimmune hypoparathyroidism may a first sign of OPS type 1. Therefore, young
patients with hypocalcemia should be
followed on regüler basis for related other autoimmune disease that may occur
over time.

References

  • 1. Perheentupa J. APS-I/APECED: the clinical disease and therapy. Endocrinol Metab Clin N Am. 2002;31(2):295-320.
  • 2. Buzi F, Badolato R, Mazza C, Giliani S, Notarangelo LD, Radetti G et al. Autoimmune Polyendocrinopathy-Candidosis-Ectodermal Dystrophy Syndrome: Time to review diagnostic criteria? J Clin Endocrinol Metab. 2003;88(7):3146-8.
  • 3. Meloni A, Willcox N, Meager A, Atzeni M, Wolff AS, Husebye ES et al. Autoimmune polyendocrine syndrome type 1: an extensive longitudinal study in Sardinian patients. J Clin Endocrinol Metab. 2012;97(4):1114-24.
  • 4. Bruserud O, Oftedal BE, Landegren N. A Longitudinal Follow-up of Autoimmune Polyendocrine Syndrome Type 1. J Clin Endocrinol Metab. 2016;101(8):2975-83.
  • 5. Owen CJ, Cheetham TD, Pearce SHS. Polyglandular Syndromes. Brook CGD, Clayton PE, Brown RS, eds. Brook's Clinical Pediatric Endocrinology 6th ed. West Sussex, UK: Wiley-Blackwell. 2009:327-42.
  • 6. Brun JM. Juvenile autoimmune polyendocrinopathy. Horm Res. 1982;16(5):308-16.
  • 7. Husebye SE, Anderson MS, Kämpe O. Autoimmune Polyendocrine Syndromes. N Engl J Med. 2018;378:1132-41. Doi: 10.1056/NEJMra1713301.
  • 8. Alimohammadi M, Björklund P, Hallgren A, Pöntynen N, Szinnai G, Shikama N et al. Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen. N Engl J Med. 2008;358(10):1018-28.
  • 9. Puel A, Doffinger R, Natividad A, Chrabieh M, Barcenas-Morales G, Picard C et al. Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. J Exp Med. 2010; 207(2): 291-7.
  • 10. Betterle C, Zancbetta R. Update on autoimmune polyendocrine syndromes. Acta Biomed. 2003;74(1):9-33.
  • 11. Dilek E, Iscan B, Ekuklu G, Tutunculer F. Retrospective evaluation of the cases diagnosed as Hashimoto’s Thyroiditis. J Child. 2000;11(2):73-7.
  • 12. Perheentupa J. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Clin Endocrinol Metab. 2006;91(8):2843-50.
  • 13. Maclaren N, Chen QY, Kukreja A, Marker J, Zhang CH, Sun ZS. Autoimmune hypogonadism as part of an autoimmune polyglandular syndrome. J Soc Gynecol Investig. 2001;8(1):52-4.
  • 14. Betterle C, Dal Pra C, Mantero F, Zanchetta R. Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: Autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction. Endocr Rev. 2002;23:327-64.
  • 15. Bakalov VK, Vanderhoof VH, Bondy CA, Nelson LM. Adrenal antibodies detect asymptomatic auto-immune adrenal insufficiency in young women with spontaneous premature ovarian failure. Hum Reprod. 2002;17(8):2096-100.

HİPOKALSEMİ İLE BAŞVURAN BİR OTOİMMUN POLİGLANDÜLER SENDROM TİP 1 OLGUSU

Year 2019, , 109 - 114, 30.04.2019
https://doi.org/10.24938/kutfd.426463

Abstract

Otoimmun
poliglandüler sendrom tip 1 (OPS tip 1) oldukça nadir görülen monogenik,
otozomal resesif geçişli bir hastalıktır. Kronik mukokutanöz kandidiyazis,
hipoparatiroidizm ve otoimmun adrenal yetmezlikten oluşan major bulguların
ikisinin varlığı ile tanımlanır. Sekonder otoimmun bozukluklar farklı
şekillerde ve geniş bir spektrumda ortaya çıkabilir. Bu yazıda ilk olarak
başvurusunda hipokalsemi saptanması üzerine hipoparatiroidizm tanısı alan ve
izleminde otoimmun poliglandüler sendrom tip 1 olarak değerlendirilen bir olgu
sunulmuştur.
14 yaşında kız hastada ilk olarak 8 yaşında iken hipokalsemi ve
hipoparatiroidi tespit edilmiş, izlemde kronik mukokutanoz kandidiazis,
tiroidit ve hipergonadotropik hipogonadizm saptanmıştır.
Otoimmün hipoparatiroidizm OPS tip
1’in başlangıç bulgusu olabilir. Bu nedenle erken yaşlarda hipokalsemi ile
başvuran olgular
zaman içerisinde ortaya çıkabilecek eşlik eden diğer
otoimmun hastalıklar açısından düzenli aralıklarla kontrol edilmelidir.

References

  • 1. Perheentupa J. APS-I/APECED: the clinical disease and therapy. Endocrinol Metab Clin N Am. 2002;31(2):295-320.
  • 2. Buzi F, Badolato R, Mazza C, Giliani S, Notarangelo LD, Radetti G et al. Autoimmune Polyendocrinopathy-Candidosis-Ectodermal Dystrophy Syndrome: Time to review diagnostic criteria? J Clin Endocrinol Metab. 2003;88(7):3146-8.
  • 3. Meloni A, Willcox N, Meager A, Atzeni M, Wolff AS, Husebye ES et al. Autoimmune polyendocrine syndrome type 1: an extensive longitudinal study in Sardinian patients. J Clin Endocrinol Metab. 2012;97(4):1114-24.
  • 4. Bruserud O, Oftedal BE, Landegren N. A Longitudinal Follow-up of Autoimmune Polyendocrine Syndrome Type 1. J Clin Endocrinol Metab. 2016;101(8):2975-83.
  • 5. Owen CJ, Cheetham TD, Pearce SHS. Polyglandular Syndromes. Brook CGD, Clayton PE, Brown RS, eds. Brook's Clinical Pediatric Endocrinology 6th ed. West Sussex, UK: Wiley-Blackwell. 2009:327-42.
  • 6. Brun JM. Juvenile autoimmune polyendocrinopathy. Horm Res. 1982;16(5):308-16.
  • 7. Husebye SE, Anderson MS, Kämpe O. Autoimmune Polyendocrine Syndromes. N Engl J Med. 2018;378:1132-41. Doi: 10.1056/NEJMra1713301.
  • 8. Alimohammadi M, Björklund P, Hallgren A, Pöntynen N, Szinnai G, Shikama N et al. Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen. N Engl J Med. 2008;358(10):1018-28.
  • 9. Puel A, Doffinger R, Natividad A, Chrabieh M, Barcenas-Morales G, Picard C et al. Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. J Exp Med. 2010; 207(2): 291-7.
  • 10. Betterle C, Zancbetta R. Update on autoimmune polyendocrine syndromes. Acta Biomed. 2003;74(1):9-33.
  • 11. Dilek E, Iscan B, Ekuklu G, Tutunculer F. Retrospective evaluation of the cases diagnosed as Hashimoto’s Thyroiditis. J Child. 2000;11(2):73-7.
  • 12. Perheentupa J. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Clin Endocrinol Metab. 2006;91(8):2843-50.
  • 13. Maclaren N, Chen QY, Kukreja A, Marker J, Zhang CH, Sun ZS. Autoimmune hypogonadism as part of an autoimmune polyglandular syndrome. J Soc Gynecol Investig. 2001;8(1):52-4.
  • 14. Betterle C, Dal Pra C, Mantero F, Zanchetta R. Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: Autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction. Endocr Rev. 2002;23:327-64.
  • 15. Bakalov VK, Vanderhoof VH, Bondy CA, Nelson LM. Adrenal antibodies detect asymptomatic auto-immune adrenal insufficiency in young women with spontaneous premature ovarian failure. Hum Reprod. 2002;17(8):2096-100.
There are 15 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Case Reports
Authors

Özlem Korkmaz 0000-0001-9093-6205

Samim Özen

Damla Gökşen This is me

Şükran Darcan

Publication Date April 30, 2019
Submission Date May 23, 2018
Published in Issue Year 2019

Cite

APA Korkmaz, Ö., Özen, S., Gökşen, D., Darcan, Ş. (2019). HİPOKALSEMİ İLE BAŞVURAN BİR OTOİMMUN POLİGLANDÜLER SENDROM TİP 1 OLGUSU. The Journal of Kırıkkale University Faculty of Medicine, 21(1), 109-114. https://doi.org/10.24938/kutfd.426463
AMA Korkmaz Ö, Özen S, Gökşen D, Darcan Ş. HİPOKALSEMİ İLE BAŞVURAN BİR OTOİMMUN POLİGLANDÜLER SENDROM TİP 1 OLGUSU. Kırıkkale Üni Tıp Derg. April 2019;21(1):109-114. doi:10.24938/kutfd.426463
Chicago Korkmaz, Özlem, Samim Özen, Damla Gökşen, and Şükran Darcan. “HİPOKALSEMİ İLE BAŞVURAN BİR OTOİMMUN POLİGLANDÜLER SENDROM TİP 1 OLGUSU”. The Journal of Kırıkkale University Faculty of Medicine 21, no. 1 (April 2019): 109-14. https://doi.org/10.24938/kutfd.426463.
EndNote Korkmaz Ö, Özen S, Gökşen D, Darcan Ş (April 1, 2019) HİPOKALSEMİ İLE BAŞVURAN BİR OTOİMMUN POLİGLANDÜLER SENDROM TİP 1 OLGUSU. The Journal of Kırıkkale University Faculty of Medicine 21 1 109–114.
IEEE Ö. Korkmaz, S. Özen, D. Gökşen, and Ş. Darcan, “HİPOKALSEMİ İLE BAŞVURAN BİR OTOİMMUN POLİGLANDÜLER SENDROM TİP 1 OLGUSU”, Kırıkkale Üni Tıp Derg, vol. 21, no. 1, pp. 109–114, 2019, doi: 10.24938/kutfd.426463.
ISNAD Korkmaz, Özlem et al. “HİPOKALSEMİ İLE BAŞVURAN BİR OTOİMMUN POLİGLANDÜLER SENDROM TİP 1 OLGUSU”. The Journal of Kırıkkale University Faculty of Medicine 21/1 (April 2019), 109-114. https://doi.org/10.24938/kutfd.426463.
JAMA Korkmaz Ö, Özen S, Gökşen D, Darcan Ş. HİPOKALSEMİ İLE BAŞVURAN BİR OTOİMMUN POLİGLANDÜLER SENDROM TİP 1 OLGUSU. Kırıkkale Üni Tıp Derg. 2019;21:109–114.
MLA Korkmaz, Özlem et al. “HİPOKALSEMİ İLE BAŞVURAN BİR OTOİMMUN POLİGLANDÜLER SENDROM TİP 1 OLGUSU”. The Journal of Kırıkkale University Faculty of Medicine, vol. 21, no. 1, 2019, pp. 109-14, doi:10.24938/kutfd.426463.
Vancouver Korkmaz Ö, Özen S, Gökşen D, Darcan Ş. HİPOKALSEMİ İLE BAŞVURAN BİR OTOİMMUN POLİGLANDÜLER SENDROM TİP 1 OLGUSU. Kırıkkale Üni Tıp Derg. 2019;21(1):109-14.

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