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NÖTROFİL VE LENFOSİT DEĞERLERİNİN AKUT KOLESİSTİT TANISINDAKİ YERİ

Year 2021, , 92 - 98, 30.04.2021
https://doi.org/10.24938/kutfd.811331

Abstract

Amaç: Bu çalışmada kolesistektomi geçirecek hastaların preoperative akut kolesistit tanısında nötrofil/lenfosit oranının prediktif değerinin olup olmadığının ortaya konulması amaçlanmıştır.
Gereç ve Yöntemler: Araştırma kapsamında 2018-2020 yılları arasında akut kolesistektomi ve elektif kolesistektomi yapılan kura ile seçilen toplam 100 hasta değerlendirildi. Hastaların dosyalarından yaş, cinsiyet, operasyon yöntemi (laparoskopik veya açık), yatış süresi, operasyon öncesi son bakılan nötrofil ve lenfosit sayıları kaydedildi. Histopatolojik olarak akut kolesistit ve kolelitiyazis tanısının doğrulandığı hastalar nötrofil lenfosit sayılarının oranları açısından karşılaştırılarak bu verilerin tanısal değeri ROC eğrileri ve çapraz tablolar ile belirlendi. p<0.05 değeri istatistiksel olarak anlamlı kabul edildi.
Bulgular: Akut kolesistektomi grubunda yer alan hastaların Nötrofil/lenfosit oranının elektif kolesistektomi grubunda yer alan hastalara göre istatistiksel olarak daha anlamlı yüksek olduğu saptandı (p=0.001). Lökosit ve platelet/lenfosit oranının da benzer şekilde akut kolesistektomi yapılan hastalarda elektif kolesistektomi yapılan hastalara göre belirgin olarak daha yüksek düzeyde olduğu saptandı (p=0.001).
Sonuç: Çalışmamızdan elde ettiğimiz veriler doğrultusunda nötrofil/lenfosit oranının akut kolesistit vakalarında prediktif değerinin olduğu görülmektedir.

References

  • 1. Peery AF, Crockett SD, Barritt AS, Dellon ES, Eluri S, Gangarosa LM et al. Burden of gastrointestinal, liver, and pancreatic diseases in the United States. Gastroenterology. 2015;149(7):1731-41.
  • 2. Kimura Y, Takada T, Strasberg SM, Pitt HA, Gouma DJ, Garden OJ et al. TG13 Current terminology, etiology, and epidemiology of acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci. 2013;20(1):8-23.
  • 3. Hwang H, Marsh I, Doyle J. Does ultrasonography accurately diagnose acute cholecystitis? Improving diagnostic accuracy based on a review at a regional hospital. Can J Surg. 2014;57(3):162-8.
  • 4. Emet M, Eroğlu M, Aslan Ş, Öztürk G. Karın ağrısı olan hastaya yaklaşım. Eurasian J Med. 2007;39:136-41.
  • 5. Papadakis M, Ambe PC, Zirngibl H. Critically ill patients with acute cholecystitis are at increased risk for extensive gallbladder inflammation. World J Emerg Surg. 2015;10:59.
  • 6. Lee SW, Yang SS, Chang CS, Yeh HJ. Impact of the Tokyo guidelines on the management of patients with acute calculous cholecystitis. J Gastroenterol Hepatol. 2009;24(12):1857-61.
  • 7. Türkmen K, Erdur FM, Özçiçek F, Özçiçek A, Akbaş EM, Özbiçer A et al. Platelet-to-lymphocyte ratio better predicts inflammation than neutrophil-to-lymphocyte ratio in end-stage renal disease patients. Hemodial Int. 2013;17(3):391-6.
  • 8. Balta S, Demirkol S, Çelik T, Küçük U, Ünlü M, Arslan Z et al. Association between coronary artery ectasia and neutrophil-lymphocyte ratio. Angiology. 2013;64(8):627-32.
  • 9. Chandrashekara S, Mukhtar Ahmad M, Renuka P, Anupama KR, Renuka K. Characterization of neutrophil-to-lymphocyte ratio as a measure of inflammation in rheumatoid arthritis. Int J Rheum Dis. 2017;20(10):1457-67.
  • 10. Kim YW, Kim SK, Kim CS, Kim IY, Cho MY, Kim NK. Association of serum and intratumoral cytokine profiles with tumor stage and neutrophil lymphocyte ratio in colorectal cancer. Anticancer Res. 2014;34(7):3481-7.
  • 11. Morizawa Y, Miyake M, Shimada K, Hori S, Tatsumi Y, Nakai Y et al. Correlation of ımmune cells and cytokines in the tumor microenvironment with elevated neutrophil-to-lymphocyte ratio in blood: an analysis of muscle-ınvasive bladder cancer. Cancer Invest. 2018;36(7):395-405.
  • 12. Mantovani A, Allavena P, Sica A. Kansere bağlı inflamasyon. Doğa. 2008;454(7203):436-44.
  • 13. Kwon HC, Kim SH, Oh SY. Ameliyat edilebilir kolorektal kanserli hastalarda preoperatif nötrofil-lenfositin trombosit-lenfosit oranına karşı klinik önemi. Biyobelirteçler. 2012;17(3):216-22.
  • 14. Zahorec R. Nötrofilin lenfosit sayılarına oranı- kritik hastalıkta hızlı ve basit bir sistemik inflamasyon ve stres parametresi. Bratisl Lek Listy. 2001;102(1):5-14.
  • 15. Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med. 2012;26:5(1):2.
  • 16. Ansaloni L, Pisano M, Coccolini F, Peitzmann AB, Fingerhut A, Catena F et al. 2016 WSES guidelines on acute calculous cholecystitis. World J Emerg Surg. 2016;11:25.
  • 17. Fried GM, Barkun JS, Sigman HH, Joseph L, Clas D, Garzon J et al. Factors determining conversion to laparotomy in patients undergoing laparoscopic cholecystectomy. Am J Surg. 1994;167(1):35-41.
  • 18. Ekici U, Yılmaz S, Tatlı F. Comparative analysis of laparoscopic cholecystectomy performed in the elderly and younger patients: should we abstain from laparoscopic cholecystectomy in the elderly? Cureus J. 2018;10(6):e2888.
  • 19. Ertok İ, Karakayalı O, Kocasaban D. Clinical ımportance of neutrophil/lymphocyte ratio ın differential diagnosis of acute cholecystitis and cholelithiasis. Kocaeli Medical J. 2016;5(3):6-11.
  • 20. Halpin V, Gupta A. Acute cholecystitis. BMJ Clin Evid. 2011;2011:0411.
  • 21. Girgin S, Gedik E, Aldemir M, Yağmur Y. Akut kolesistitte güncel tedavi ve cerrahi. Türkiye Klinikleri J Surg Med Sci. 2007;3(28):44-9.
  • 22. Yazıcı P, Demir U, Bozdağ E, Bozkurt E, Isil RG, Bostancı Ö et al. What is the effect of treatment modality on red blood cell distribution width in patients with acute cholecystitis? Ulusal Cer Derg. 2015;31(1):1-4.
  • 23. Lee SK, Lee SC, Park JW, Kim SJ. The utility of the preoperative neutrophil-to-lymphocyte ratio in predicting severe cholecystitis: a retrospective cohort study. BMC Surg. 2014;14:100.

The Role of Neutrophil and Lymphocyte Values in the Diagnosis of Acute Cholecystitis

Year 2021, , 92 - 98, 30.04.2021
https://doi.org/10.24938/kutfd.811331

Abstract

Objective: In this study, it was aimed to reveal whether the preoperative neutrophil-lymphocyte ratio values of the patient groups who underwent acute and elective cholecystectomy have predictive value.
Material and Methods: Within the scope of the study, patients who underwent cholecystectomy between 2018-2020 were evaluated. Age, gender, operation method (laparoscopic or open), length of stay, neutrophil and lymphocyte counts were recorded from the patients' files. Patients whose diagnosis of acute cholecystitis and cholelithiasis were confirmed histopathologically, were compared in terms of the ratio of neutrophil lymphocyte counts, and the diagnostic value of these data was determined by ROC curves and cross tables.
Results: The leukocyte and platelet lymphocyte ratio values of the patients in the acute cholecystectomy group were found to be significantly higher than the patients in the elective cholecystectomy group (p=0.001). Similarly, the neutrophil-lymphocyte ratio was found to be significantly higher in patients who underwent acute cholecystectomy compared to patients that underwent elective cholecystectomy (p=0.001).
Conclusion: In line with the data, we obtained from our study, it is seen that the neutrophil-lymphocyte ratio value is a predictive value in cases of acute cholecystitis.

References

  • 1. Peery AF, Crockett SD, Barritt AS, Dellon ES, Eluri S, Gangarosa LM et al. Burden of gastrointestinal, liver, and pancreatic diseases in the United States. Gastroenterology. 2015;149(7):1731-41.
  • 2. Kimura Y, Takada T, Strasberg SM, Pitt HA, Gouma DJ, Garden OJ et al. TG13 Current terminology, etiology, and epidemiology of acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci. 2013;20(1):8-23.
  • 3. Hwang H, Marsh I, Doyle J. Does ultrasonography accurately diagnose acute cholecystitis? Improving diagnostic accuracy based on a review at a regional hospital. Can J Surg. 2014;57(3):162-8.
  • 4. Emet M, Eroğlu M, Aslan Ş, Öztürk G. Karın ağrısı olan hastaya yaklaşım. Eurasian J Med. 2007;39:136-41.
  • 5. Papadakis M, Ambe PC, Zirngibl H. Critically ill patients with acute cholecystitis are at increased risk for extensive gallbladder inflammation. World J Emerg Surg. 2015;10:59.
  • 6. Lee SW, Yang SS, Chang CS, Yeh HJ. Impact of the Tokyo guidelines on the management of patients with acute calculous cholecystitis. J Gastroenterol Hepatol. 2009;24(12):1857-61.
  • 7. Türkmen K, Erdur FM, Özçiçek F, Özçiçek A, Akbaş EM, Özbiçer A et al. Platelet-to-lymphocyte ratio better predicts inflammation than neutrophil-to-lymphocyte ratio in end-stage renal disease patients. Hemodial Int. 2013;17(3):391-6.
  • 8. Balta S, Demirkol S, Çelik T, Küçük U, Ünlü M, Arslan Z et al. Association between coronary artery ectasia and neutrophil-lymphocyte ratio. Angiology. 2013;64(8):627-32.
  • 9. Chandrashekara S, Mukhtar Ahmad M, Renuka P, Anupama KR, Renuka K. Characterization of neutrophil-to-lymphocyte ratio as a measure of inflammation in rheumatoid arthritis. Int J Rheum Dis. 2017;20(10):1457-67.
  • 10. Kim YW, Kim SK, Kim CS, Kim IY, Cho MY, Kim NK. Association of serum and intratumoral cytokine profiles with tumor stage and neutrophil lymphocyte ratio in colorectal cancer. Anticancer Res. 2014;34(7):3481-7.
  • 11. Morizawa Y, Miyake M, Shimada K, Hori S, Tatsumi Y, Nakai Y et al. Correlation of ımmune cells and cytokines in the tumor microenvironment with elevated neutrophil-to-lymphocyte ratio in blood: an analysis of muscle-ınvasive bladder cancer. Cancer Invest. 2018;36(7):395-405.
  • 12. Mantovani A, Allavena P, Sica A. Kansere bağlı inflamasyon. Doğa. 2008;454(7203):436-44.
  • 13. Kwon HC, Kim SH, Oh SY. Ameliyat edilebilir kolorektal kanserli hastalarda preoperatif nötrofil-lenfositin trombosit-lenfosit oranına karşı klinik önemi. Biyobelirteçler. 2012;17(3):216-22.
  • 14. Zahorec R. Nötrofilin lenfosit sayılarına oranı- kritik hastalıkta hızlı ve basit bir sistemik inflamasyon ve stres parametresi. Bratisl Lek Listy. 2001;102(1):5-14.
  • 15. Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med. 2012;26:5(1):2.
  • 16. Ansaloni L, Pisano M, Coccolini F, Peitzmann AB, Fingerhut A, Catena F et al. 2016 WSES guidelines on acute calculous cholecystitis. World J Emerg Surg. 2016;11:25.
  • 17. Fried GM, Barkun JS, Sigman HH, Joseph L, Clas D, Garzon J et al. Factors determining conversion to laparotomy in patients undergoing laparoscopic cholecystectomy. Am J Surg. 1994;167(1):35-41.
  • 18. Ekici U, Yılmaz S, Tatlı F. Comparative analysis of laparoscopic cholecystectomy performed in the elderly and younger patients: should we abstain from laparoscopic cholecystectomy in the elderly? Cureus J. 2018;10(6):e2888.
  • 19. Ertok İ, Karakayalı O, Kocasaban D. Clinical ımportance of neutrophil/lymphocyte ratio ın differential diagnosis of acute cholecystitis and cholelithiasis. Kocaeli Medical J. 2016;5(3):6-11.
  • 20. Halpin V, Gupta A. Acute cholecystitis. BMJ Clin Evid. 2011;2011:0411.
  • 21. Girgin S, Gedik E, Aldemir M, Yağmur Y. Akut kolesistitte güncel tedavi ve cerrahi. Türkiye Klinikleri J Surg Med Sci. 2007;3(28):44-9.
  • 22. Yazıcı P, Demir U, Bozdağ E, Bozkurt E, Isil RG, Bostancı Ö et al. What is the effect of treatment modality on red blood cell distribution width in patients with acute cholecystitis? Ulusal Cer Derg. 2015;31(1):1-4.
  • 23. Lee SK, Lee SC, Park JW, Kim SJ. The utility of the preoperative neutrophil-to-lymphocyte ratio in predicting severe cholecystitis: a retrospective cohort study. BMC Surg. 2014;14:100.
There are 23 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Tayfun Bilgiç 0000-0002-7564-3663

Ersan Özkardeşler This is me 0000-0003-0665-688X

Ali Sürmelioğlu This is me 0000-0002-7697-0930

Publication Date April 30, 2021
Submission Date October 15, 2020
Published in Issue Year 2021

Cite

APA Bilgiç, T., Özkardeşler, E., & Sürmelioğlu, A. (2021). NÖTROFİL VE LENFOSİT DEĞERLERİNİN AKUT KOLESİSTİT TANISINDAKİ YERİ. The Journal of Kırıkkale University Faculty of Medicine, 23(1), 92-98. https://doi.org/10.24938/kutfd.811331
AMA Bilgiç T, Özkardeşler E, Sürmelioğlu A. NÖTROFİL VE LENFOSİT DEĞERLERİNİN AKUT KOLESİSTİT TANISINDAKİ YERİ. Kırıkkale Üni Tıp Derg. April 2021;23(1):92-98. doi:10.24938/kutfd.811331
Chicago Bilgiç, Tayfun, Ersan Özkardeşler, and Ali Sürmelioğlu. “NÖTROFİL VE LENFOSİT DEĞERLERİNİN AKUT KOLESİSTİT TANISINDAKİ YERİ”. The Journal of Kırıkkale University Faculty of Medicine 23, no. 1 (April 2021): 92-98. https://doi.org/10.24938/kutfd.811331.
EndNote Bilgiç T, Özkardeşler E, Sürmelioğlu A (April 1, 2021) NÖTROFİL VE LENFOSİT DEĞERLERİNİN AKUT KOLESİSTİT TANISINDAKİ YERİ. The Journal of Kırıkkale University Faculty of Medicine 23 1 92–98.
IEEE T. Bilgiç, E. Özkardeşler, and A. Sürmelioğlu, “NÖTROFİL VE LENFOSİT DEĞERLERİNİN AKUT KOLESİSTİT TANISINDAKİ YERİ”, Kırıkkale Üni Tıp Derg, vol. 23, no. 1, pp. 92–98, 2021, doi: 10.24938/kutfd.811331.
ISNAD Bilgiç, Tayfun et al. “NÖTROFİL VE LENFOSİT DEĞERLERİNİN AKUT KOLESİSTİT TANISINDAKİ YERİ”. The Journal of Kırıkkale University Faculty of Medicine 23/1 (April 2021), 92-98. https://doi.org/10.24938/kutfd.811331.
JAMA Bilgiç T, Özkardeşler E, Sürmelioğlu A. NÖTROFİL VE LENFOSİT DEĞERLERİNİN AKUT KOLESİSTİT TANISINDAKİ YERİ. Kırıkkale Üni Tıp Derg. 2021;23:92–98.
MLA Bilgiç, Tayfun et al. “NÖTROFİL VE LENFOSİT DEĞERLERİNİN AKUT KOLESİSTİT TANISINDAKİ YERİ”. The Journal of Kırıkkale University Faculty of Medicine, vol. 23, no. 1, 2021, pp. 92-98, doi:10.24938/kutfd.811331.
Vancouver Bilgiç T, Özkardeşler E, Sürmelioğlu A. NÖTROFİL VE LENFOSİT DEĞERLERİNİN AKUT KOLESİSTİT TANISINDAKİ YERİ. Kırıkkale Üni Tıp Derg. 2021;23(1):92-8.

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