SODYUM GLUKOZ KO-TRANSPORTER 2 İNHİBİTÖRLERİNİN PLEİOTROPİK ETKİLERİ

Year 2016, Volume: 18 Issue: 2, 75 - 79, 31.08.2016

Aslı F. Ceylan

https://doi.org/10.24938/kutfd.252681

Abstract

Diabetes
mellitus, insulin rezistansı, insulin sekresyonundaki bozukluk veya
sekresyonunun olmayışından ya da bunların bir arada bulunmasından kaynaklanan
hiperglisemi ile karakterize kronik metabolik bir hastalıktır. Diyabetik
bireyler için iyi bir glisemik kontrol çok önemlidir. Ne yazık ki, diyabetik
bireylerin pek çoğunda, kabul edilebilir bir glisemik kontrole
ulaşılamamaktadır. Bu nedenle de diyabet ile ilgili komplikasyonlardan
kaynaklanan morbidite ve mortalite yüksektir. Sodyum glukoz ko-transporter-2
(SGLT2) inhibitörleri, benzersiz etki mekanizmasına sahip, yeni bir
antidiyabetik ilaç sınıfıdır. Bu çalışma, SGLT2 inhibitörlerinin pleiotropik
etkilerine ilişkin genel bilgi sağlamaktadır. Bu amaçla, ilgili makaleler
PubMed ve Uluslararası Farmasötik Özetler aracılığıyla taranmıştır. Taramada
kullanılan anahtar kelimeler: “canagliflozin, dapagliflozin, empagliflozin,
pleiotropic effects, sodium-glucose co transporter 2 inhibitors” olarak
seçilmiştir.

Keywords

Diyabet, diyabetik komplikasyonlar, pleiotropik etki, SGLT2 inhibitörleri

Pleiotropic Effects of Sodium - Glucose Co-Transporter 2 Inhibitors

Abstract

Diabetes
mellitus is a chronic metabolic disorder characterized by hyperglycemia because
of insulin resistance, diminished or absent insulin secretion or both. Good
glycemic control is one of the most important issues for diabetic individual.
Unfortunately, most of the diabetics fail to achieve acceptable glycemic
control. Therefore, diabetes-associated morbidity and mortality is high
resulting from complications. The sodium-glucose co-transporter 2 (SGLT2)
inhibitors are a new class of antidiabetic agents with a unique mechanism of
action. This article provides an overview of pleiotropic effects of SGLT2
inhibitors. For this purpose, relevant articles were identified through
searches of PubMed and International Pharmaceutical Abstracts by using the key
words diabetes, canagliflozin, dapagliflozin, empagliflozin, pleiotropic
effects, sodium-glucose co transporter 2 inhibitors.

Keywords

Diabetes, diabetic complications, pleiotropic effect, SGLT2 inhibitors

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