Paratiroid Adenomunun Ameliyat Öncesi Tanısında Öngörücü Bir Biyobelirteç Olarak Trombosit/Lenfosit Oranı

Year 2019, Volume: 21 Issue: 1, 73 - 79, 30.04.2019

Oktay Aydın Faruk Pehlivanlı

https://doi.org/10.24938/kutfd.522955

Cited By: 1

Abstract

Amaç: Trombosit lenfosit oranı (PLR) ve nötrofilin lenfosit oranı (NLR) değerlerinin pekçok inflamatuvar ve malign hastalığın prognoz ve tanısında kullanımına yönelik çalışmalar her geçen gün artarak devam etmektedir. PLR ve NLR nin bir biyobelirteç olarak kullanılabilirliği fikri pek çok araştırmacının ilgisini bu alana çekmektedir. Bu retrospektif vaka kontrol çalışmasının amacı, PLR ve NLR değerlerinin paratiroid adenomu tanısındaki rolünü araştırmaktır.

Gereç ve Yöntemler: Bu çalışmaya paratiroid adenomu olan 17 hasta (PAD grubu) dahil edildi ve bu hastalara ait PLR ve NLR değerleri sağlıklı bireylerden oluşan Kontrol grubu (15 katılımcı) değerleri ile karşılaştırıldı.

Bulgular: PAD grubunun lenfosit sayım değerleri CONTROL grubundan anlamlı derecede yüksekti. Trombosit sayısı ve NLR değerleri gruplar arasında farklı değildi. PAD grubunun PLR değerleri Kontrol grubundakilerden anlamlı derecede düşüktü. ROC-Curve analizi sonuçları, trombosit lenfosit oranı değeri <125 olduğunda, paratiroid adenomlu hastaların sağlıklı bireylerden ayrılmasında spesifik ve hassas bir biyobelirteç olabileceğini göstermiştir.

Sonuç: Sonuç olarak, primer hiperparatiroidizm hastalarında ölçülen düşük trombosit lenfosit oranı değerleri paratiroid adenomu tanısı için preoperatif yeni bir biyobelirteç olabilir.

Keywords

Primer hiperparatiroidizm, paratiroid adenomu, nötrofil lenfosit oranı, trombosit lenfosit oranı

PLATELET TO LYMPHOCYTE RATIO AS A PREDICTIVE BIOMARKER FOR PREOPERATIVE DIAGNOSIS OF PARATHYROID ADENOMA

Abstract

Objective: There is a significant increase in studies concerning the use of platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) for diagnosis and prognosis in many inflammatory and malignant diseases. The idea that PLR and NLR can be used as a biomarker attracts many researchers to this area. The aim of this retrospective case control study was to investigate the role of PLR and NLR values in diagnosis of the parathyroid adenoma.

Material and Methods: In this study, 17 patients with parathyroid adenoma (PAD group) were included and the PLR and NLR values of these patients were compared with control group (15 participants) consisted of healthy subjects.

Results: The lymphocyte count values of the PAD group were significantly higher than those of the CONTROL group. The platelet count and NLR values were not different between the groups. The PLR values of the PAD group were significantly lower than those of the CONTROL groups. ROC-Curve analysis results showed that if platelet to lymphocyte ratio value was <125, it could be a specific and sensitive biomarker in discrimination of patients with parathyroid adenoma from healthy individuals.

Conclusion: In conclusion, low PLR values measured in patients with primary hyperparathyroidism could be a new preoperative diagnostic biomarker for parathyroid adenoma.

Keywords

Primary hyperparathyroidism, parathyroid adenoma, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio

References

• 1. Cheng SP, Liu CL, Liu TP, Hsu YC, Lee JJ. Association between parathyroid hormone levels and inflammatory markers among US adults. Mediators of Inflammation. 2014;2014:709024.
• 2. Kamani F, Najafi A, Mohammadi S, Tavassoli S, Shojaei S. Correlation of biochemical markers of primary hyperparathyroidism with single adenoma weight and volume. Indian Journal of Surgery. 2013;75(2):102-5.
• 3. Clark OH, Duh QY. Primary hyperparathyroidism: a surgical perspective. Endocrinology and Metabolism Clinics of North America. 1989;18(3):701-14.
• 4. Dubest C, Bordier P. The estimation of PTH in primary hyperparathyroidism. Nouvelle Presse Med. 1985;7:21-5.
• 5. Wagner P, Rothmund M. Correlation of tumor weight and typical pathologic laboratory parameters in primary and secondary hyperparathyroidism. Langenbecks Archiv fur Chirurgie. 1983;360(2):133-9.
• 6. Mózes G, Curlee KJ, Rowland CM, van Heerden JA, Thompson GB, Grant CS et al. The predictive value of laboratory findings in patients with primary hyperparathyroidism. Journal of the American College of Surgeons. 2002;194(2):126-30.
• 7. Yang PS, Liu CL, Liu TP, Chen HH, Wu CJ, Cheng SP. Parathyroidectomy decreases neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios. Journal of Surgical Research. 2018;224:169-75.
• 8. Zeren S, Yaylak F, Ozbay I, Bayhan Z. Relationship between the neutrophil to lymphocyte ratio and parathyroid adenoma size in patients with primary hyperparathyroidism. International Surgery. 2015;100(7):1185-9.
• 9. Carneiro DM, Solorzano CC, Nader MC, Ramirez M, Irvin GL. Comparison of intraoperative iPTH assay (QPTH) criteria in guiding parathyroidectomy: which criterion is the most accurate? Surgery. 2003;134(6):973-9.
• 10. Pehlivanli F, Aydin O. Factors Affecting Mortality in Fournier Gangrene: A Single Center Experience. Surgical Infections. 2018;20(1):78-82.
• 11. Jiang K, Lei J, Chen W, Gong Y, Luo H, Li Z et al. Association of the preoperative neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with lymph node metastasis and recurrence in patients with medullary thyroid carcinoma. Medicine. 2016;95(40).e5079.
• 12. Aydin O, Pehlivanli F. Is the platelet to lymphocyte ratio a potential biomarker for predicting mortality in peptic ulcer perforation? Surg Infect (Larchmt). 2019:(Epub 2019 Feb 8). Doi: 10.1089/sur.2018.288.
• 13. Wang X, Zhang G, Jiang X, Zhu H, Lu Z, Xu L. Neutrophil to lymphocyte ratio in relation to risk of all-cause mortality and cardiovascular events among patients undergoing angiography or cardiac revascularization: a meta-analysis of observational studies. Atherosclerosis. 2014;234(1):206-13.