The Importance of Hematological Parameters in Recurrent Pregnancy Loss

Year 2019, Volume: 21 Issue: 1, 85 - 89, 30.04.2019

Mahmut İlkin Yeral Buğra Coşkun Bora Coşkun Fatih Karslı Coşkun Cimşir

https://doi.org/10.24938/kutfd.524640

Abstract

Objective:
We aimed to investigate hematological parameter changes in recurrent pregnancy
loss patients.

Material and Method: Two-hundred and fifty-two patients with at least two
abortions admitted to our clinic were included in the study. Patients in Group 1 (n=198) had two consecutive pregnancy losses
whereas patients in Group 2 (n=54) had at least three consecutive pregnancy
losses. Demographic data and hematological parameters were evaluated
retrospectively.

Results: When the demographic data were compared,
there was no statistically significant difference between the mean ages of
groups (p=0.069). In terms of body mass index, gravida, parity, number of
living children, there was a statistically significant difference between the
two groups and Group 2 was significantly higher than Group 1 (p<0.05). The
anticardiolipin antibody IgM and IgG values of Group 2 was significantly higher
than the values of Group 1 (p<0.05). In terms of APTT, PT, INR, fibrinogen,
active protein-C resistance, antithrombin-3, protein C, protein S values, there
was no statistically significant difference between the groups (p>0.05).

Conclusion: It has been concluded
that antiphospholipid antibody screening will be a cost-effective and effective
approach in patients with recurrent pregnancy loss.

Keywords

Recurrent pregnancy loss, anticardiolipin antibody, antiphospholipid syndrome

TEKRARLAYAN GEBELİK KAYBINDA HEMATOLOJİK PARAMETRELERİN ÖNEMİ

Abstract

Amaç: Tekrarlayan
gebelik kaybı hastalarında hematolojik parametre değişikliklerini incelemeyi
hedefledik.

Gereç ve Yöntem:
Kliniğimize
başvuran ardışık en az iki düşük yapmış 252 hasta çalışmaya dahil edildi. Ardışık
iki düşük yapan hastalar 1. grup (n=198), üç ve üstü
düşük yapan hastalar ise 2. grup (n=54) olarak isimlendirildi. Hastaların yatış
dosyasındaki demografik veriler ve hematolojik parametreler retrospektif olarak
incelendi.

Bulgular: Demografik veriler karşılaştırıldığında;
grupların yaş ortalamaları arasında istatistiksel olarak anlamlı bir fark
saptanmadı (p=0.069). Vücut kütle indeksi, gravida, parite, yaşayan çocuk
sayısı bakımından ise iki grup arasında istatistiksel olarak anlamlı fark
saptandı ve 2. grupta daha yüksekti (p<0.05). Laboratuvar parametrelerinde
ise; 2. grupta antikardiolipin IgM ve IgG değerleri istatistiksel olarak
anlamlı derecede yüksek saptandı (p<0.05). APTT, PT, INR, fibrinojen, aktive
protein-C rezistansı, antitrombin-3, protein C, protein S değerleri bakımından
iki grup arasında istatistiksel olarak anlamlı fark saptanmadı (p>0.05).

Sonuç: Tekrarlayan gebelik kaybı olan hastalarda antifosfolipid antikor
taramanın, düşük maliyetli ve etkili bir yaklaşım olacağı sonucuna varılmıştır.

Keywords

Tekrarlayan gebelik kaybı, antikardiolipin antikor, antifosfolipid sendrom

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