Case Report
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IS EMERGENCY ROOM OBSERVATION SUFFICIENT FOR MAD HONEY POISONING? A CASE REPORT

Year 2021, Volume: 23 Issue: 1, 174 - 179, 30.04.2021
https://doi.org/10.24938/kutfd.789412

Abstract

Grayanotoxin poisoning is most commonly seen in the East Black Sea Region of Turkey due to consumption of mad honey, which is made by bees from the flowers of the rhododendron plant. Mad honey poisoning is dose dependent. In low doses, it causes dizziness, hypotension and bradycardia. In high doses, it can cause unconsciousness, seizures and atrioventricular blocks. Local people are well aware of mad honey poisoning and generally do not go to the hospital for mild symptoms. In clinical practice, patients with mad honey poisoning are kept under coronary intensive care observation for at least 12-24 hours. As seen in this case report as well as in some publications in the literature, stable patients who respond to atropine and fluid therapy may not need to be hospitalized. In this case report, we present a patient with sinus bradycardia due to mad honey poisoning from the East Black Sea Region of Turkey, who responded to intravenous fluid and atropine treatment in a short time.

References

  • 1. Erenler AK. Cardiac Effects of mad honey poisoning and ıts management in emergency department: A review from Turkey. Cardiovasc Toxicol. 2016;16(1):1-4.
  • 2. Gunduz A, Durmus I, Turedi S, Nuhoglu I, Ozturk S. Mad honey poisoning-related asystole. Emerg Med J. 2007;24(8):592-3.
  • 3. Maejima H, Kinoshita E, Seyama I, Yamaoka K. Distinct sites regulating grayanotoxin binding and unbinding to D4S6 of Na (v) 1.4 sodium channel as revealed by improved estimation of toxin sensitivity. J Biol Chem. 2003;278(11):9464-71.
  • 4. Onat FY, Kurtel H, Yegen BC, Lawrence R, Oktay A, Oktay S. Mad honey poisoning in man and rat. Rev Environ Health. 1991;9(1):3-9.
  • 5. Gunduz A, Turedi S, Uzun H, Topbas M. Mad honey poisoning. Am J Emerg Med. 2006;24(5):595-8.
  • 6. Tatli O. The Black Sea’s poison; Mad honey. J Anal Res Clin Med. 2017;5(1):1-3.
  • 7. Gunduz A, Meriçe ES, Baydın A, Topbaş M, Uzun H, Türedi S et al. Does mad honey poisoning require hospital admission? Am J Emerg Med. 2009;27(4):424-7.

Deli Bal Zehirlenmelerinde Acil Servis Gözlemi Yeterli Midir? Vaka Sunumu

Year 2021, Volume: 23 Issue: 1, 174 - 179, 30.04.2021
https://doi.org/10.24938/kutfd.789412

Abstract

Türkiye'nin Doğu Karadeniz bölgesinde daha sıklıkla gözlenen grayanotoksin zehirlenmesi, ormangülü bitkisinin çiçeklerinden beslenen arıların yaptığı deli baldan kaynaklanmaktadır. Deli bal zehirlenmeleri doz bağımlıdır. Düşük dozlarda baş dönmesi, hipotansiyon ve bradikardiye neden olurken yüksek dozlarda bilinç bozukluğu, nöbet ve atriyoventriküler bloklara neden olabilmektedir. Doğu Karadeniz Bölgesi halkı deli bal zehirlenmesi konusunda tecrübeli olduğu için hafif semptomları olduğunda genellikle hastaneye başvurmazlar. Klinik pratikte deli bal zehirlenmesi olan hastalar en az 12-24 saat koroner yoğun bakım gözlemi altında tutulmaktadırlar. Literatürdeki bazı yayınlarda olduğu gibi bu vaka sunumunda da görüldüğü üzere atropin ve sıvı tedavisine yanıt veren stabil hastaların hastanede yatmalarına gerek olmayabilir. Biz bu vaka sunumunda Doğu Karadeniz kaynaklı deli bal zehirlenmesine bağlı sinüs bradikardisi olan, intravenöz sıvı ve atropin tedavisine kısa sürede yanıt veren bir hastadan bahsedeceğiz.

References

  • 1. Erenler AK. Cardiac Effects of mad honey poisoning and ıts management in emergency department: A review from Turkey. Cardiovasc Toxicol. 2016;16(1):1-4.
  • 2. Gunduz A, Durmus I, Turedi S, Nuhoglu I, Ozturk S. Mad honey poisoning-related asystole. Emerg Med J. 2007;24(8):592-3.
  • 3. Maejima H, Kinoshita E, Seyama I, Yamaoka K. Distinct sites regulating grayanotoxin binding and unbinding to D4S6 of Na (v) 1.4 sodium channel as revealed by improved estimation of toxin sensitivity. J Biol Chem. 2003;278(11):9464-71.
  • 4. Onat FY, Kurtel H, Yegen BC, Lawrence R, Oktay A, Oktay S. Mad honey poisoning in man and rat. Rev Environ Health. 1991;9(1):3-9.
  • 5. Gunduz A, Turedi S, Uzun H, Topbas M. Mad honey poisoning. Am J Emerg Med. 2006;24(5):595-8.
  • 6. Tatli O. The Black Sea’s poison; Mad honey. J Anal Res Clin Med. 2017;5(1):1-3.
  • 7. Gunduz A, Meriçe ES, Baydın A, Topbaş M, Uzun H, Türedi S et al. Does mad honey poisoning require hospital admission? Am J Emerg Med. 2009;27(4):424-7.
There are 7 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Case Reports
Authors

Metin Ocak 0000-0002-9978-0216

Nur Şimşek Yurt 0000-0002-6585-9663

Publication Date April 30, 2021
Submission Date September 2, 2020
Published in Issue Year 2021 Volume: 23 Issue: 1

Cite

APA Ocak, M., & Şimşek Yurt, N. (2021). IS EMERGENCY ROOM OBSERVATION SUFFICIENT FOR MAD HONEY POISONING? A CASE REPORT. The Journal of Kırıkkale University Faculty of Medicine, 23(1), 174-179. https://doi.org/10.24938/kutfd.789412
AMA Ocak M, Şimşek Yurt N. IS EMERGENCY ROOM OBSERVATION SUFFICIENT FOR MAD HONEY POISONING? A CASE REPORT. Kırıkkale Uni Med J. April 2021;23(1):174-179. doi:10.24938/kutfd.789412
Chicago Ocak, Metin, and Nur Şimşek Yurt. “IS EMERGENCY ROOM OBSERVATION SUFFICIENT FOR MAD HONEY POISONING? A CASE REPORT”. The Journal of Kırıkkale University Faculty of Medicine 23, no. 1 (April 2021): 174-79. https://doi.org/10.24938/kutfd.789412.
EndNote Ocak M, Şimşek Yurt N (April 1, 2021) IS EMERGENCY ROOM OBSERVATION SUFFICIENT FOR MAD HONEY POISONING? A CASE REPORT. The Journal of Kırıkkale University Faculty of Medicine 23 1 174–179.
IEEE M. Ocak and N. Şimşek Yurt, “IS EMERGENCY ROOM OBSERVATION SUFFICIENT FOR MAD HONEY POISONING? A CASE REPORT”, Kırıkkale Uni Med J, vol. 23, no. 1, pp. 174–179, 2021, doi: 10.24938/kutfd.789412.
ISNAD Ocak, Metin - Şimşek Yurt, Nur. “IS EMERGENCY ROOM OBSERVATION SUFFICIENT FOR MAD HONEY POISONING? A CASE REPORT”. The Journal of Kırıkkale University Faculty of Medicine 23/1 (April 2021), 174-179. https://doi.org/10.24938/kutfd.789412.
JAMA Ocak M, Şimşek Yurt N. IS EMERGENCY ROOM OBSERVATION SUFFICIENT FOR MAD HONEY POISONING? A CASE REPORT. Kırıkkale Uni Med J. 2021;23:174–179.
MLA Ocak, Metin and Nur Şimşek Yurt. “IS EMERGENCY ROOM OBSERVATION SUFFICIENT FOR MAD HONEY POISONING? A CASE REPORT”. The Journal of Kırıkkale University Faculty of Medicine, vol. 23, no. 1, 2021, pp. 174-9, doi:10.24938/kutfd.789412.
Vancouver Ocak M, Şimşek Yurt N. IS EMERGENCY ROOM OBSERVATION SUFFICIENT FOR MAD HONEY POISONING? A CASE REPORT. Kırıkkale Uni Med J. 2021;23(1):174-9.

This Journal is a Publication of Kırıkkale University Faculty of Medicine.