Diyabet ve Sistemik Enflamasyon Parametrelerinin Bell Palsisinin Prognozuna Etkisi

Year 2021, Volume: 23 Issue: 1, 132 - 142, 30.04.2021

Ziya Şencan , Ela Cömert , Gökçe Şimşek , Nuray Bayar Muluk , Serdar Hanzala Yaman

https://doi.org/10.24938/kutfd.878035

Abstract

Amaç: Bell palsili hastalarda, diyabetin prognostik önemini, nötrofil-lenfosit oranı, trombosit-lenfosit oranı, sistemik inflamasyon yanıt indeksi dahil hematolojik ve biyokimyasal test bulgularını değerlendirmek, ayrıca Bell palsili hastalarda trigliserid-glikoz indeksini değerlendirmek ve bu sonuçları sağlıklı deneklerle karşılaştırmaktır.

Gereç ve Yöntemler: Çalışmaya, Bell palsisi komplet olmayan 75 hasta ve kontrol grubu olarak 24 sağlıklı birey dahil edildi. Hastalar diyabet olan ve diyabet olmayan olarak iki gruba ayrıldı. Tüm deneklerden tam kan sayımı, glikoz, karaciğer ve böbrek fonksiyon testleri gibi biyokimyasal testler ve kan lipid profili analiz edildi ve bu sonuçlardan nötrofil-lenfosit oranı, trombosit-lenfosit oranı, sistemik inflamasyon yanıt indeksi ve trigliserid-glikoz indeksi değerleri hesaplandı.

Bulgular: Nötrofil-lenfosit oranı ve sistemik inflamasyon yanıt indeksi değerleri Bell palsili hastalarda kontrol grubuna göre daha yüksekti. Trigliserid-glikoz indeksi, tüm hastalarda ve diyabet grubunda iyileşme süresi ile pozitif korelasyon gösterdi. Trigliserid-glikoz indeksi ayrıca diyabet olmayan hastalarda prognoz ile pozitif korelasyon gösterdi. Yüksek nötrofil-lenfosit oranı, sadece diyabet olmayan hastalarda gecikmiş iyileşme süresi için öngörücüydü.

Sonuç: Sonuçlarımız, diyabetin Bell palsinin şiddetini, iyileşme süresini ve prognozunu etkilemediğini gösterdi. Nötrofil-lenfosit oranı ve sistemik inflamasyon yanıt indeksi değerleri Bell palsili hastalarda anlamlı olarak yüksekti. Yüksek trigliserid seviyeleri ve trigliserid-glikoz indeksi değerleri Bell palsili hastalarda uzun iyileşme süresi ile ilişkilendirildi. Hem diyabet hem de diyabet olmayan hastalar için, the House-Brackmann facial nerve grading scale-initial prognozu tahmin etmek için en iyi parametreydi.

Keywords

Bell palsisi, Diyabet, inflamasyon, prognoz

Supporting Institution

YOK

Project Number

YOK

EFFECT OF DIABETES AND SYSTEMIC INFLAMMATION PARAMETERS ON THE PROGNOSIS OF BELL’S PALSY

Abstract

Objective: This study aimed to evaluate the prognostic importance of diabetes mellitus, hematologic and biochemical test findings including neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic inflammation response index and triglyceride-glucose index in patients with Bell’s palsy and to compare these results with healthy subjects.

Material and Methods: The study included 75 patients with incomplete Bell’s palsy.

and 24 healthy subjects as the control group. Patients were divided into two groups as diabetes mellitus and non- diabetes mellitus patients. Complete blood count, biochemical tests including glucose, liver and renal function tests and blood lipid profile were analyzed from all the subjects and neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic inflammation response index and triglyceride-glucose index values were calculated from these results.

Results: Neutrophil-to-lymphocyte ratio and systemic inflammation response index values were higher in patients with Bell’s palsy when compared with the control group. Triglyceride-glucose index was positively correlated with recovery time in all patients and the diabetes mellitus group. It was also positively correlated with prognosis in non- diabetes mellitus patients. High neutrophil-to-lymphocyte ratio was predictive for delayed recovery time only in non- diabetes mellitus patients.

Conclusion: Our results indicated that diabetes mellitus didn’t influence severity, recovery time and prognosis of Bell’s palsy. High triglyceride levels and triglyceride-glucose index values were associated with long recovery time in patients with Bell’s palsy. For both diabetes mellitus and non- diabetes mellitus patients, House-Brackmann facial nerve grading scale-initial was the best parameter to predict the prognosis. Neutrophil-to-lymphocyte ratio and systemic inflammation response index values were significantly higher in patients with Bell’s palsy.

Keywords

Bell's palsy, Diabetes Mellitus, inflammation, prognosis

Project Number

YOK

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