COMPARISON OF INFECTED LUNG VOLUME OF COVID-19 PATIENTS AND THEIR CLINIC AND LABORATORY DATA

Year 2022, Volume: 24 Issue: 1, 63 - 72, 30.04.2022

Murathan Köksal , Erdem Özkan , Mutlu Gülbay Yeşim Aybar Bilir Esragül Akınci , Adalet Aypak , Hatice Rahmet Güner

https://doi.org/10.24938/kutfd.1008677

Abstract

Objective: In this study, it was aimed to evaluate the healthy and infected area volumes and elementary lesion characteristics in thorax computed tomography examinations of mild-moderate and severe patient groups according to the clinical severity scoring determined by the World Health Organization, and to compare the obtained findings with laboratory and clinical data.

Material and Methods: A total of 100 cases (59 males, 41 females; age range 18-95 years) were retrospectively and randomly selected from the patients who had non-contrast thoracic computed tomography scan and were diagnosed with Covid-19 pneumonia by reverse transcription polymerase chain reaction test. According to clinical severity scoring, patients were classified as mild-moderate and severe groups. Volumetric measurements were made in the lungs using quantitative analyses. In addition, lesion characteristics (ground glass opacity, consolidation, air bronchogram) in the infiltration areas were recorded. The relationship between radiological findings and clinical-laboratory data was statistically evaluated.

Results: The age of the patients ranged between 58.80±14.74 years; 52% of the cases were in the severe category, 48% of them were in the mild-moderate category. Lung volumes did not differ significantly between disease groups. According to computed tomography findings, there was a statistically significant correlation between subpleural reticulations and air bronchogram and disease groups. IL-6, D-dimer, ferritin, neutrophil lymphocyte ratio and C-Reactive Protein values were higher in the severe disease group than in the mild-moderate group.

Conclusion: Volumetric values associated with laboratory parameters are thought to be an important indicator of the immune response that determines the course of the disease.

Keywords

COVID-19, Computed Tomography, Volumetry

Covıd-19 Hastalarında Enfekte Akciğer Volümü ile Klinik ve Laboratuvar Bulguların Karşılaştırılması

Abstract

Amaç: Bu çalışmada, Dünya Sağlık Örgütü’nün belirlediği klinik şiddet skorlamasına göre hafif-orta grup ile ağır hasta gruplarının toraks bilgisayarlı tomografi tetkiklerinde sağlıklı ve enfekte alan volümleri ile elementer lezyon özelliklerinin değerlendirilmesi, elde edilen bulguların laboratuvar ve klinik verilerle karşılaştırılması amaçlanmıştır.

Gereç ve Yöntemler: Hastaneye kabul sırasında kontrastsız toraks bilgisayarlı tomografisi çekilen ve ters transkripsiyon polimeraz zincir reaksiyonu testi ile Covid-19 pnömonisi tanısı alan hastalar arasından geriye dönük ve rastgele olarak toplam 100 olgu (59 erkek, 41 kadın; yaş aralığı 18-95) toplandı. Klinik şiddet skorlamasına göre hastalar hafif-orta ve ağır grup olarak sınıflandırıldı. Kantitatif analizler kullanılarak akciğerlerde volümetrik ölçümler yapıldı. Ayrıca infiltrasyon alanlarındaki lezyon özellikleri (buzlu cam opasitesi, konsolidasyon, hava bronkogramı vb.) kaydedildi. Radyolojik bulgular ve klinik-laboratuvar veriler arasındaki ilişki istatistiksel olarak değerlendirildi.

Bulgular: Hastaların yaşları 58.80±14.74/yıl arasında değişmekte olup; olguların %52’si ağır kategoride, %48’i hafif-orta kategorideydi. Akciğer hacimleri, hastalık grupları arasında anlamlı farklılık göstermiyordu. Bilgisayarlı tomografi bulgularına göre subplevral retikülasyonlar ile hava bronkogramı ve hastalık grupları arasında istatistiksel olarak anlamlı bir ilişki mevcuttu. IL-6, D-dimer, ferritin, nötrofil lenfosit oranı ve C-Reaktif Protein değerleri ağır hastalık grubunda, hafif-orta gruba göre daha yüksekti.

Sonuç: Laboratuvar parametreleriyle ilişkilendirilen hacimsel değerlerin, hastalığın seyrini belirleyen immün yanıtının önemli bir göstergesi olduğu düşünülmektedir.

Keywords

COVID-19, Bilgisayarlı Tomografi, Volumetri

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