Romatoid Artritte Yeni Bir İnflamasyon Belirteci: İmmatür Granülosit

Year 2023, Volume: 25 Issue: 1, 56 - 63, 30.04.2023

Esra Özcan , Sedat Gülten

https://doi.org/10.24938/kutfd.1143318

Cited By: 1

Abstract

Amaç: Bu çalışmanın amacı immatür granülosit sayısının, romatoid artritte hastalık ativitesini gösteren bir belirteç olup olmadığını ortaya koymaktır.

Gereç ve Yöntemler: Çalışmaya, Kastamonu Rehabilitasyon Merkezi'nde romatoid artrit tanısı ile takipli 163 hasta alındı. Hastaların verileri, laboratuar bilgi sisteminden bulundu. Kontrol grubu için 92 sağlıklı bireyin laboratuvar verileri kullanıldı. Aktif enfeksiyonu, hematolojik, kardiyovasküler, metabolik ve malign hastalığı olan hastalar ile son 15 gün içinde travma, cerrahi girşim ve hastaneye yatış öyküsü olanlar çalışma dışı bırakıldı.

Bulgular: Hasta grubunda immatür granülosit sayısı ve yüzdesinin anlamlı olarak daha yüksek olduğunu bulundu (p<0.05). Hasta grubunda immatür granülosit ile eritrosit sedimentasyon hızı (r=0.171 p=0.03), ve C-reaktif protein (r=0.321 p<0.001) arasında pozitif ilişki saptandı. Yine hasta grubunda grubunda, immatür granülosit sayısı ve yüzdesi, C-reaktif protein düzeyi >5 olan hastalarda, C-reaktif protein düzeyi <5 olanlara göre istatistiksel olarak anlamlı derecede yüksekti (p<0.05).

Sonuç: İmmatür granülosit seviyesi, romatoid artritte inflamasyonu gösteren hızlı, kolay erişilebilir ve uygun maliyetli bir belirteç olabilir.

Keywords

Romatoid artrit, immatür granülosit, hastalık aktivitesi

A NEW INFLAMMATION MARKER IN RHEUMATOID ARTHRITIS: IMMATURE GRANULOCYTE

Abstract

Objective: This study aimed to reveal whether immature granulocyte levels can be used for determining the disease activity of rheumatoid arthritis.

Material and Methods: The study was conducted in the Kastamonu Rehabilitation Center. The data of 163 patients with rheumatoid arthritis were reviewed retrospectively. Laboratory data of 92 healthy individuals were used for the control group. Complete blood cell counts, measurement of erythrocyte sedimentation rate, and C-reactive protein level were used for the laboratory assessments. The individuals with active infection and any hematological, cardiovascular, metabolic disorder, malignancy, history of trauma, surgery, and hospitalization within the last 15 days were excluded from the study.

Results: We found that the number and percentage of immature granulocyte were significantly higher in the patient group (p<0.05). A positive correlation was found between immature granulocyte and erythrocyte sedimentation rate (r=0.171 p=0.03), immature granulocyte and C-reactive protein (r=0.321 p<0.001) in the patient group. In the rheumatoid arthritis group, the number and percentage of immature granulocytes were statistically significantly higher in patients with C-reactive protein >5 than those with C-reactive protein ≤ 5 (p<0.05).

Conclusion: The immature granulocytes can be a rapid, easily accessible and cost-effective parameter that indicates inflammation in rheumatoid arthritis. It may be useful to use this parameter in the evaluation of disease activity.

Keywords

Rheumatoid arthritis, immature granulocyte, disease activity

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