Erişkin bir Diyabetes Mellitus Hastasında Geç Başlangıçlı Nevüs Komedonikus
Year 2025,
Volume: 27 Issue: 2, 246 - 249, 25.08.2025
Metin Özaslan
,
Zeliha Çelik
Abstract
Nevus komedonikus (NC) klasik olarak dilate foliküler ostia ve komedon benzeri hiperkeratotik foliküler tıkaçlarla karakterize pilosebase ünitenin bir malformasyonu olarak tanımlanır. Klasik tipin yanı sıra, inflamatuar lezyonların eşlik ettiği inflamatuar NC (NC süpürativa) literatürde nadiren bildirilmiştir. 47 yaşında diyabetes mellituslu (DM) bir erkek hastada alın orta hattında yerleşen geç başlangıçlı NC süpürativa olgusu sunulmuştur. Hastanın NC sendromu için yapılan iskelet sistemi, merkezi sinir sistemi, diş ve göz muayeneleri normaldi. NC süpürativa ve DM birlikteliğinin tesadüfi olmayabileceğini düşünüyoruz. NC suppurativa hastalarının DM belirtileri açısından düzenli olarak izlenmesi yararlı olabilir. Gelecek çalışmalarda DM ile ilişkiyi netleştirmek için NC süpürativa’lı tüm hastalarda DM açısından tanısal testler yapılmalıdır.
References
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Sharma S, Sahu P, Dayal S, Yadav A, Brar K. Nevus comedonicus suppurativa: A report of a novel entity. J Clin Aesthet Dermatol. 2020;13(6):36-39.
-
Zanniello R, Pilloni L, Conti B, Faa G, Rongioletti F. Late-onset nevus comedonicus with follicular epidermolytic hyperkeratosis-case report and review of the literature. Am J Dermatopathol. 2019;41(6):453-455.
-
Grimalt R, Caputo R. Posttraumatic nevus comedonicus. J Am Acad Dermatol. 1993;28(2 Pt 1):273-274.
-
Levinsohn JL, Sugarman JL; Yale Center for Mendelian Genomics; McNiff JM, Antaya RJ, Choate KA. Somatic mutations in NEK9 cause nevus comedonicus. Am J Hum Genet. 2016;98(5):1030-1037.
-
Liu F, Yang Y, Zheng Y, Liang YH, Zeng K. Mutation and expression of ABCA12 in keratosis pilaris and nevus comedonicus. Mol Med Rep. 2018;18(3):3153-3158.
-
Melnik B, Schmitz G. FGFR2 signaling and the pathogenesis of acne. J Dtsch Dermatol Ges. 2008;6(9):721-728.
-
Mazzella C, Fabbrocini G, Luciano MA, Cacciapuoti S. Nevus comedonicus with acne vulgaris and obesity. Dermatol Pract Concept. 2019;10(1):e2020006.
-
Laplante M, Sabatini DM. mTOR signaling at a glance. J Cell Sci. 2009;122(Pt 20):3589-3594.
-
Banerjee M, Saxena M. Interleukin-1 (IL-1) family of cytokines: role in type 2 diabetes. Clin Chim Acta. 2012;413(15-16):1163-1170.
-
Eom YS, Gwon AR, Kwak KM, et al. Notch1 has an important role in β-cell mass determination and development of diabetes. Diabetes Metab J. 2021;45(1):86-96.
-
Miranda JJ, Taype-Rondan A, Tapia JC, Gastanadui-Gonzalez MG, Roman-Carpio R. Hair follicle characteristics as early marker of type 2 diabetes. Med Hypotheses. 2016;95:39-44.
-
Okoro OE, Camera E, Flori E, Ottaviani M. Insulin and the sebaceous gland function. Front Physiol. 2023;14:1252972.
-
Dufour DN, Bryld LE, Jemec GB. Hidradenitis suppurativa complicating naevus comedonicus: the possible influence of mechanical stress on the development of hidradenitis suppurativa. Dermatology. 2010;220(4):323–325.
-
Qian G, Liu T, Zhou C, Zhang Y. Naevus comedonicus syndrome complicated by hidradenitis suppurativa-like lesions responding to acitretin treatment. Acta Derm Venereol. 2015;95(8):992–993.
-
Manikavachakan N, Siddaraju MN, Rajendran SC, Venkataraman A. Extensive nevus comedonicus, complicated with recurrent abscesses, successfully treated with surgical resurfacing. J Cutan Aesthet Surg. 2018;11(1):33–37.
LATE-ONSET NEVUS COMEDONICUS IN AN ADULT PATIENT WITH DIABETES MELLITUS
Year 2025,
Volume: 27 Issue: 2, 246 - 249, 25.08.2025
Metin Özaslan
,
Zeliha Çelik
Abstract
Nevus comedonicus (NC) is classically defined as a malformation of the pilosebaceous unit characterized by dilated follicular ostia and comedone-like hyperkeratotic follicular plugs. In addition to the classical type, inflammatory NC (NC suppurativa) is accompanied by inflammatory lesions and has been rarely reported in the literature. We report a case of late-onset NC suppurativa on the midline of the forehead in a 47-year-old male patient with diabetes mellitus (DM). Skeletal, central nervous system, dental, and ophthalmologic examinations for NC syndrome were normal. The coexistence of NC suppurativa and DM may not be incidental. Regular monitoring of patients with NC suppurativa for signs of DM could be beneficial. Future studies should include diagnostic tests for DM in all patients with NC suppurativa to clarify the potential link with DM.
References
-
Sharma S, Sahu P, Dayal S, Yadav A, Brar K. Nevus comedonicus suppurativa: A report of a novel entity. J Clin Aesthet Dermatol. 2020;13(6):36-39.
-
Zanniello R, Pilloni L, Conti B, Faa G, Rongioletti F. Late-onset nevus comedonicus with follicular epidermolytic hyperkeratosis-case report and review of the literature. Am J Dermatopathol. 2019;41(6):453-455.
-
Grimalt R, Caputo R. Posttraumatic nevus comedonicus. J Am Acad Dermatol. 1993;28(2 Pt 1):273-274.
-
Levinsohn JL, Sugarman JL; Yale Center for Mendelian Genomics; McNiff JM, Antaya RJ, Choate KA. Somatic mutations in NEK9 cause nevus comedonicus. Am J Hum Genet. 2016;98(5):1030-1037.
-
Liu F, Yang Y, Zheng Y, Liang YH, Zeng K. Mutation and expression of ABCA12 in keratosis pilaris and nevus comedonicus. Mol Med Rep. 2018;18(3):3153-3158.
-
Melnik B, Schmitz G. FGFR2 signaling and the pathogenesis of acne. J Dtsch Dermatol Ges. 2008;6(9):721-728.
-
Mazzella C, Fabbrocini G, Luciano MA, Cacciapuoti S. Nevus comedonicus with acne vulgaris and obesity. Dermatol Pract Concept. 2019;10(1):e2020006.
-
Laplante M, Sabatini DM. mTOR signaling at a glance. J Cell Sci. 2009;122(Pt 20):3589-3594.
-
Banerjee M, Saxena M. Interleukin-1 (IL-1) family of cytokines: role in type 2 diabetes. Clin Chim Acta. 2012;413(15-16):1163-1170.
-
Eom YS, Gwon AR, Kwak KM, et al. Notch1 has an important role in β-cell mass determination and development of diabetes. Diabetes Metab J. 2021;45(1):86-96.
-
Miranda JJ, Taype-Rondan A, Tapia JC, Gastanadui-Gonzalez MG, Roman-Carpio R. Hair follicle characteristics as early marker of type 2 diabetes. Med Hypotheses. 2016;95:39-44.
-
Okoro OE, Camera E, Flori E, Ottaviani M. Insulin and the sebaceous gland function. Front Physiol. 2023;14:1252972.
-
Dufour DN, Bryld LE, Jemec GB. Hidradenitis suppurativa complicating naevus comedonicus: the possible influence of mechanical stress on the development of hidradenitis suppurativa. Dermatology. 2010;220(4):323–325.
-
Qian G, Liu T, Zhou C, Zhang Y. Naevus comedonicus syndrome complicated by hidradenitis suppurativa-like lesions responding to acitretin treatment. Acta Derm Venereol. 2015;95(8):992–993.
-
Manikavachakan N, Siddaraju MN, Rajendran SC, Venkataraman A. Extensive nevus comedonicus, complicated with recurrent abscesses, successfully treated with surgical resurfacing. J Cutan Aesthet Surg. 2018;11(1):33–37.