İnsan ve Hayvanlarda Nonalkolik Yağlı Karaciğer Hastalığı/Hepatik Steatozisin Tedavisinde Bitkisel İlaçların Etkinliği

Abstract

Keywords

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Efficacy of Herbal Remedies in The Treatment of Nonalcholic Fatty Liver Disease/Hepatic Steatosis in Human and Animals

Öz

Alkol alımı ile ilgili olmayan yağlı karaciğer hastalıkları (NAFLD) geçmişte alkol kullanmamış hastaların karaciğerlerinde aşırı yağ birikmesi durumunu ifade eder. NAFLD, alkol alımı ile ilgili olmayan steatohepatit (NASH), kriptojenik karaciğer sirozu ve hepatoselüler karsinoma varan yaygın karaciğer hücre yıkımı hasarını ifade eder. NASH’ın patogenezi multifaktöriyel olup, muhtemel en önemli faktörler; insülin rezistansı ve artan yağ asidi nedeniyle karaciğer hücrelerinde yağ birikimi, oksidanlara bağlı stres, lipid peroksidasyon, mitokondrial fonksiyon bozukluğu ve değişen oranlardaki sitokinlerin regülasyon bozuklukları steatotik karaciğerde hepatoselüler hasarın en önemli sebepleridir. Etki mekanizmalarının ve gerçek etkilerinin daha çok bilimsel araştırmalarla kanıtlanmasına gerek duyulmasına rağmen, bitkisel ilaçlar karaciğer yangıları ve karaciğer yağlanması ile ilişkili diğer semptomların tedavilerinde uzun süreden beri kullanılmaktadırlar. Bu derlemede, hayvan çalışmalarının geliştirilmesinin gerekliliği üzerine kısmen vurgu yapmakla birlikte, NAFLD’nin bitkisel ilaçlarla tedavisindeki özellikleri mevcut durumu ve yeni terapötik yaklaşımların geliştirilmesi için fırsatlar sağlamaya çalıştık

Anahtar Kelimeler

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