İnsan ve Hayvanlarda Nonalkolik Yağlı Karaciğer Hastalığı/Hepatik Steatozisin Tedavisinde Bitkisel İlaçların Etkinliği

Abstract

Keywords

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Efficacy of Herbal Remedies in The Treatment of Nonalcholic Fatty Liver Disease/Hepatic Steatosis in Human and Animals

Öz

Alkol alımı ile ilgili olmayan yağlı karaciğer hastalıkları (NAFLD) geçmişte alkol kullanmamış hastaların karaciğerlerinde aşırı yağ birikmesi durumunu ifade eder. NAFLD, alkol alımı ile ilgili olmayan steatohepatit (NASH), kriptojenik karaciğer sirozu ve hepatoselüler karsinoma varan yaygın karaciğer hücre yıkımı hasarını ifade eder. NASH’ın patogenezi multifaktöriyel olup, muhtemel en önemli faktörler; insülin rezistansı ve artan yağ asidi nedeniyle karaciğer hücrelerinde yağ birikimi, oksidanlara bağlı stres, lipid peroksidasyon, mitokondrial fonksiyon bozukluğu ve değişen oranlardaki sitokinlerin regülasyon bozuklukları steatotik karaciğerde hepatoselüler hasarın en önemli sebepleridir. Etki mekanizmalarının ve gerçek etkilerinin daha çok bilimsel araştırmalarla kanıtlanmasına gerek duyulmasına rağmen, bitkisel ilaçlar karaciğer yangıları ve karaciğer yağlanması ile ilişkili diğer semptomların tedavilerinde uzun süreden beri kullanılmaktadırlar. Bu derlemede, hayvan çalışmalarının geliştirilmesinin gerekliliği üzerine kısmen vurgu yapmakla birlikte, NAFLD’nin bitkisel ilaçlarla tedavisindeki özellikleri mevcut durumu ve yeni terapötik yaklaşımların geliştirilmesi için fırsatlar sağlamaya çalıştık

Anahtar Kelimeler

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Kaynakça

1. Aghazadeh S. Amini R. Yazdanparast
2. R. Ghaffari SH. 2011. Anti-apoptotic and anti-inflammatory
3. marianum in treatment of experimental
4. steatohepatitis. 63(6):569-74. effects of Silybum Exp Toxicol Pathol.
5. Angulo P. Lindor KD. 2002. Non-alcoholic fatty liver disease. Journal of Gastroenterology and Hepatology. 17:186–S190.
6. Angulo P. Lindor KD. 2011. Treatment of non- alcoholic fatty liver: present and emerging therapies. Sem. Liver Dis. 21: 81–8.
7. Balch AP. 2010. Prescription for Nutritional Healing. 4 th edition. Avery Trade; 5 Rev Upd edition, USA
8. Ballentani S. Saccoccio G. Masutti F. 2000. Prevalence of and risk factors for hepatic steatosis in northern Italy. Ann. Intern. Med. 132: 112–7.

9. Cohen JC. Horton JD. Hobbs HH. 2011. Human fatty liver disease: old questions and new insights. Science. 332: 1519-1523
10. Dong H. Lu FE. Zhao L. 2012. Chinese herbal medicine in the treatment of nonalcoholic fatty liver disease. Chin J Integr Med. 18(2):152-60.
11. Franzese A. Vajro P. Argenziano A. 1997. Liver involvement Ultrasonography and liver enzyme levels at diagnosis and during follow-up in an Italian population. Dig. Dis. Sci. 42: 1438–2.
12. Fujimoto M. Tsuneyama K. Kinoshita H. Goto H. Takano CL. Gershwin ME. Shimada Y. 2010. The traditional Japanese formula keishibukuryogan reduces liver injury and inflammation in patients with nonalcoholic fatty liver disease. Ann N Y Acad Sci. 1190:151-8.
13. Harrison SA. Torgerson S. Hayashi PH. 2003. The natural history of nonalcoholic fatty liver disease: a clinical histopathological study. Am J Gastroenterol. 98: 2042-2047.
14. Hebbard L. George J. 2011. Animal models of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol. 8: 35-44
15. Kuo JJ. Chang HH. Tsai TH. Lee TY. 2012. Curcumin dysfunction associated with inhibition of gluconeogenesis in free fatty acid-mediated hepatic lipoapoptosis. Int J Mol Med. 30(3):643-9. mitochondrial
16. Li HS. Feng Q. Xu LL. Chen SD. Li XM. Hu YY. 2009. Effects of Qushi Huayu Decoction in prevention and treatment of fatty liver in rats based on adiponectin-free fatty acid pathway. Zhong Xi Yi Jie He Xue Bao. 7(6):546-51.
17. Lugasi A. Blazovics A. Hagymasi K. Kocsis I. Kery A. 2005. Antioxidant effect of squeezed from black radish (Raphanus sativus L. var niger) in alimentary hyperlipidaemia in rats. Phytother Res. 19(7):587-91. juice
18. Luper S. 1998. A review of plants used in the treatment of liver disease: part 1. Altern Med Rev. 3(6):410-21.
19. Luyckx FH. Desaive C. Thiry A. 1998. Liver abnormalities in severely obese subjects. effect of drastic weight loss after gastroplasty. Int. J. Obes. 22: 222–6.
20. Mao ZM. Song HY. Yang LL. Liu T. Li DF. Zheng PY. Liu P. Ji G. 2012. Effects of the mixture of Swertia pseudochinensis Hara and Silybum marianum Gaertn extracts on CCl(4)-induced liver injury in rats with non- alcoholic fatty liver disease. Zhong Xi Yi Jie He Xue Bao. 10(2):193-9.
21. Neuschwander-Tetri BA. 2005. Nonalcoholic steatohepatitis and the metabolic syndrome. Am J Med Sci. 330: 326-335.
22. Park CM. Youn HJ. Chang HK. Song YS. 2010. TOP1 from Taraxacum officinale, attenuate CCl(4)- induced hepatic damage through the modulation of NF-kappaB and its regulatory mediators. Food Chem Toxicol. 48(5):1255- 61.
23. Powell EE. Cooksley WG. Hanson R. Searle J. Halliday JW. Powell LW. 1990. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology. 11(1):74-80.
24. Schattenberg JM. Galle PR. 2010. Animal models of non-alcoholic teatohepatitis: of mice and man. Dig Dis. 28: 247-254.
25. Schrader R. 1956. Black radish in the treatment of liver and Hippokrates. 27(17):561-3. duct diseases.
26. Shi KQ. Fan YC. Liu WY. Li LF. Chen YP. Zheng MH. 2012. Traditional Chinese medicines benefit to nonalcoholic fatty liver disease: a systematic review and meta-analysis. Mol Biol Rep. 39, (10): 9715-9722.
27. Takahashi Y. Fukusato T. 2008. Pathology of nonalcoholic steatohepatitis. In: Current Research in Hepatology 2. Trivandrum: Research Media. 99-112.
28. Takahashi Y. Soejima Y. Fukusato T. 2012. Animal models of nonalcoholic fatty liver disease/ nonalcoholic steatohepatitis. World J Gastroenterol. 18(19): 2300-2308.
29. Tseng SH. Chien TY. Chen JR. Lin IH. Wang CC. 2011. Hypolipidemic effects of three purgative Complement Alternat Med. 2011:249-254. Evid Based
30. Xu LM. Hu YY. 2003. Studies on treatment of fatty liver with traditional Chinese medicine. Zhong Xi Yi Jie He Xue Bao. 1(2):138-41.
31. Yang LL. Wang M. Liu T. Song HY. Li DF. Zheng PY. Liu P. Ji G. 2011. Effects of Chinese herbal medicine Jiangzhi Granule on expressions of liver X receptor α and sterol regulatory element-binding protein-1c in a rat model of non-alcoholic fatty liver disease]. Zhong Xi Yi Jie He Xue Bao. 9(9):998-1004.
32. Yang SY. Zhao NJ. Li XJ. Zhang HJ. Chen KJ. Li CD. 2012. Ping-tang Recipe improves insulin resistance and attenuates hepatic steatosis in high-fat diet-induced obese rats. Chin J Integr Med. 18(4):262-8.