Use of Vitamin C for Premedication Prior to Medetomidine–Ketamine Anesthesia in New Zealand White Rabbits

Year 2018, , 463 - 467, 15.12.2018

Rahime Yaygıngül , Zeynep Bozkan Osman Bulut Ali Belge

https://doi.org/10.30607/kvj.431453

Abstract

This
study aimed to investigate the effects of premedication with ascorbic acid
(vitamin C) on physiologic parameters before medetomidine–ketamine anesthesia
in New Zealand white rabbits. A total of 14 rabbits of both sexes, 1-4 months
of age and 2-4 kg in body weight, were used in this study. The rabbits were
randomly assigned one of two groups: medetomidine–ketamine (MK) or ascorbic
acid–medetomidine–ketamine (AAMK). The rabbits in the MK group were given 0.25
mg/kg of medetomidine and 15 mg/kg of ketamine intramuscularly. The rabbits in
the AAMK group were given 60 mg/kg of vitamin C intramuscularly 20 min prior to
the same dose of medetomidine–ketamine anesthesia. The onset of anesthesia,
time of surgical anesthesia, and total anesthesia time in the two groups was
recorded. Heart rate, respiratory rate, and body temperature were also recorded
at 0, 5, 10, 15, 20, 25, 30, 45 and 60 minutes during anesthesia. Physiologic
parameters were not statistically different between the two groups.
Pretreatment with vitamin C prior to medetomidine–ketamine anesthesia decreased the duration of onset of anesthesia. As a
result, it was concluded that vitamin C can be used prior to anesthesia to
accelerate the effect of medetomidine–ketamine in rabbits.

Keywords

anesthesia, rabbit, vitamin C, medetomidine, ketamine

Yeni Zelanda Beyaz Tavşanlarında Medetomidin – Ketamin Anestezisi Öncesi Preanestezik Olarak Vitamin C Kullanılması

Abstract

Bu
çalışmada, beyaz Yeni Zelanda tavşanlarında medetomidin – ketamin anestezisi
öncesi preanestezik olarak uygulanan askorbik asitin (vitamin C=vit )
fizyolojik parametreler üzerine etkisinin araştırılması amaçlanmıştır. Her iki
cinsiyette 1-4 aylık ve 2-4 kg vücut ağırlığında sahip toplam 14 tavşan bu
çalışma için kullanıldı. Tavşanlar rastgele iki gruba ayrıldı; medetomidin –
ketamin (MK) ya da askorbik asit – medetomidin – ketamin (AAMK). MK grubundaki
tavşanlara 0.25 mg/kg medetomidin ve 15 mg/kg ketamin intramuscular olarak
uygulandı. AAMK grubundaki tavşanlara aynı dozdaki medetomidin-ketamin
anestezisinden 20 dk önce 60 mg/kg oranında kas içi C vitamini verildi. İki
grupta anestezi başlangıç zamanı, cerrahi anestezi süresi ve total anestezi
zamanı kaydedildi. Anestezi sırasında kalp oranı, solunum oranı ve vücut
sıcaklığı 0, 5, 10, 15, 20, 25, 30, 45 ve 60 dakikalarda kaydedildi. Fizyolojik
parametreler açısından her iki grupta istatiksel olarak fark belirlenemedi.
Sonuç olarak, tavşanlarda medetomidin – ketamin anestezisi öncesi C vitaminin
kullanılması anestezi giriş süresini kısalttığı görülmüştür.   

Keywords

vitamin C, Anestezi, tavşan, medetomidin, ketamin

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