Use of Vitamin C for Premedication Prior to Medetomidine–Ketamine Anesthesia in New Zealand White Rabbits

Abstract

This study aimed to investigate the effects of premedication with ascorbic acid (vitamin C) on physiologic parameters before medetomidine–ketamine anesthesia in New Zealand white rabbits. A total of 14 rabbits of both sexes, 1-4 months of age and 2-4 kg in body weight, were used in this study. The rabbits were randomly assigned one of two groups: medetomidine–ketamine (MK) or ascorbic acid–medetomidine–ketamine (AAMK). The rabbits in the MK group were given 0.25 mg/kg of medetomidine and 15 mg/kg of ketamine intramuscularly. The rabbits in the AAMK group were given 60 mg/kg of vitamin C intramuscularly 20 min prior to the same dose of medetomidine–ketamine anesthesia. The onset of anesthesia, time of surgical anesthesia, and total anesthesia time in the two groups was recorded. Heart rate, respiratory rate, and body temperature were also recorded at 0, 5, 10, 15, 20, 25, 30, 45 and 60 minutes during anesthesia. Physiologic parameters were not statistically different between the two groups. Pretreatment with vitamin C prior to medetomidine–ketamine anesthesia decreased the duration of onset of anesthesia. As a result, it was concluded that vitamin C can be used prior to anesthesia to accelerate the effect of medetomidine–ketamine in rabbits.

Keywords

• anesthesia,rabbit,vitamin C,medetomidine,ketamine

Yeni Zelanda Beyaz Tavşanlarında Medetomidin – Ketamin Anestezisi Öncesi Preanestezik Olarak Vitamin C Kullanılması

Öz

Bu çalışmada, beyaz Yeni Zelanda tavşanlarında medetomidin – ketamin anestezisi öncesi preanestezik olarak uygulanan askorbik asitin (vitamin C=vit ) fizyolojik parametreler üzerine etkisinin araştırılması amaçlanmıştır. Her iki cinsiyette 1-4 aylık ve 2-4 kg vücut ağırlığında sahip toplam 14 tavşan bu çalışma için kullanıldı. Tavşanlar rastgele iki gruba ayrıldı; medetomidin – ketamin (MK) ya da askorbik asit – medetomidin – ketamin (AAMK). MK grubundaki tavşanlara 0.25 mg/kg medetomidin ve 15 mg/kg ketamin intramuscular olarak uygulandı. AAMK grubundaki tavşanlara aynı dozdaki medetomidin-ketamin anestezisinden 20 dk önce 60 mg/kg oranında kas içi C vitamini verildi. İki grupta anestezi başlangıç zamanı, cerrahi anestezi süresi ve total anestezi zamanı kaydedildi. Anestezi sırasında kalp oranı, solunum oranı ve vücut sıcaklığı 0, 5, 10, 15, 20, 25, 30, 45 ve 60 dakikalarda kaydedildi. Fizyolojik parametreler açısından her iki grupta istatiksel olarak fark belirlenemedi. Sonuç olarak, tavşanlarda medetomidin – ketamin anestezisi öncesi C vitaminin kullanılması anestezi giriş süresini kısalttığı görülmüştür.   

Anahtar Kelimeler

• vitamin C,Anestezi,tavşan,medetomidin,ketamin

Kaynakça

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