Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?

Year 2018, , 501 - 507, 15.12.2018

Hadi Alihosseini , Ekrem Çağatay Çolakoğlu , Ali Evren Haydardedeoğlu Arif Kurtdede

https://doi.org/10.30607/kvj.453321

Abstract

Idiopathic hepatic
fibrosis (İHF) is an inevitable result of chronic liver disease progressing to
cirrhosis. Idiopathic Hepatic fibrosis is characterized as congenital or
juvenile form in German Shepherd Dogs. However, few data have been published on
the incidence and prevalence of IHF in canine species. The case report presented
here describes idiopathic hepatic fibrosis in four neutered German Shephered
dogs with a
familial relationship. The main clinical complaints were
refractory ascites, variable appetite and progressive weight loss. Hepatic
fibrosis was confirmed with diagnostic applications and liver biopsy.
Nevertheless, all dogs died in spite of supportive and aggressive treatment.
Necropsy was performed in the dogs according to written owner consent. In
conclusion, the cases presented here reflect the congenital condition of
idiopathic hepatic fibrosis in young German Shepherd Dogs with
histopathological evidence. However, there was evidence of familial
relationship in the cases presented here. 

Keywords

Dog, fibrosis, liver, idiopathic, genetic

Dört Alman Çoban Köpeğinde Hepatik Fibroz İdiyopatik, Genetik Yatkınlık ya da Ailesel İlişki mi?

Abstract

İdiyopatik hepatik
fibroz (İHF) siroza kadar gidebilen kronik karaciğer hastalığının kaçınılmaz
bir sonucudur. İdiyopatik hepatik fibroz, Alman Çoban Köpeklerinde jüvenil ya
da doğmasal olarak şekillenebilmektedir. Bununla birlikte, köpeklerde İHF’nin
prevalans veya insidansı hakkında az sayıda veri bulunmaktadır. Sunulan olgu
serisi, ailesel ilişkisi bulunan dört Alman Çoban Köpeğindeki idiyopatik
hepatik fibrozu tanımlamaktadır. Olgulardaki esas klinik şikayetler;
tekrarlayan asites, değişken iştah durumu ve ilerleyici kilo kaybıydı. Hepatik
fibroz tanısı diyagnostik uygulamalar ve karaciğer biyopsisi ile doğrulandı.
Destekleyici agresif tedaviye ragmen tüm köpekler kaybedildi. Hasta sahibinin
izni ile köpeklerde nekropsi gerçekleştirildi. Sonuç olarak, sunulan olgular
Alman Çoban Köpeklerinde histopatolojik kanıtı olan konjenital idiyopatik
hepatik fibrozu yansıtmaktadır. Bununla birlikte, sunulan olgularda ailesel
ilişki kanıtı da söz konusudur. 

Keywords

Fibroz, idiyopatik, karaciğer, köpek, genetic

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