Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?

Öz

Idiopathic hepatic fibrosis (İHF) is an inevitable result of chronic liver disease progressing to cirrhosis. Idiopathic Hepatic fibrosis is characterized as congenital or juvenile form in German Shepherd Dogs. However, few data have been published on the incidence and prevalence of IHF in canine species. The case report presented here describes idiopathic hepatic fibrosis in four neutered German Shephered dogs with a familial relationship. The main clinical complaints were refractory ascites, variable appetite and progressive weight loss. Hepatic fibrosis was confirmed with diagnostic applications and liver biopsy. Nevertheless, all dogs died in spite of supportive and aggressive treatment. Necropsy was performed in the dogs according to written owner consent. In conclusion, the cases presented here reflect the congenital condition of idiopathic hepatic fibrosis in young German Shepherd Dogs with histopathological evidence. However, there was evidence of familial relationship in the cases presented here. 

Anahtar Kelimeler

• Dog,fibrosis,liver,idiopathic,genetic

Dört Alman Çoban Köpeğinde Hepatik Fibroz İdiyopatik, Genetik Yatkınlık ya da Ailesel İlişki mi?

Öz

İdiyopatik hepatik fibroz (İHF) siroza kadar gidebilen kronik karaciğer hastalığının kaçınılmaz bir sonucudur. İdiyopatik hepatik fibroz, Alman Çoban Köpeklerinde jüvenil ya da doğmasal olarak şekillenebilmektedir. Bununla birlikte, köpeklerde İHF’nin prevalans veya insidansı hakkında az sayıda veri bulunmaktadır. Sunulan olgu serisi, ailesel ilişkisi bulunan dört Alman Çoban Köpeğindeki idiyopatik hepatik fibrozu tanımlamaktadır. Olgulardaki esas klinik şikayetler; tekrarlayan asites, değişken iştah durumu ve ilerleyici kilo kaybıydı. Hepatik fibroz tanısı diyagnostik uygulamalar ve karaciğer biyopsisi ile doğrulandı. Destekleyici agresif tedaviye ragmen tüm köpekler kaybedildi. Hasta sahibinin izni ile köpeklerde nekropsi gerçekleştirildi. Sonuç olarak, sunulan olgular Alman Çoban Köpeklerinde histopatolojik kanıtı olan konjenital idiyopatik hepatik fibrozu yansıtmaktadır. Bununla birlikte, sunulan olgularda ailesel ilişki kanıtı da söz konusudur. 

Anahtar Kelimeler

• Fibroz,idiyopatik,karaciğer,köpek,genetic

Kaynakça

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