İntraperitoneal ve İnsizyonel Sprey Lidokain Uygulaması Köpeklerde Ovaryohisterektomi Sonrası Erken Postoperatif Ağrıyı Azaltır

Abstract

Sunulan çalışmada, ovariohisterektomi yapılan köpeklerde intraperitoneal ve insizyonel sprey lidokain uygulamasının operasyon sonrası stres, oksidatif stres ve ağrı üzerine etkilerinin araştırılması amaçlandı. Kontrol grubuna (n=12) sprey şeklinde intraperitoneal ve insizyonel % 0.9 NaCl uygulanırken, deneme grubu (n=12) bireysel doz hesaplamasını takiben eşit dozda % 0.9 NaCl ile hazırlanmış lidokain (8,8 mg/kg) aldı. Modifiye Melbourne ağrı skorlaması sedasyon öncesi (T), operasyon bitimi (T0), operasyondan 30 dakika (T½), 1 (T1), 2 (T2), 4 (T4) ve 6 (T6) saat sonra gerçekleştirildi. İlgili zamanlarda venöz kan örnekleri alınarak, serum kortizol, total oksidan durum (TOD) ve total antioksidan durum (TAD) ölçümleri yapıldı. Oksidatif stres indeksi (OSI) TOD/TAD oranına göre belirlendi. Kortizol, TAD ve OSI değerlerinin gruplar arasında istatistiksel olarak fark oluşturmadığı belirlendi (p > 0.05). Deneme grubunda TOD düzeyinin T1 zamanında en yüksek seviyede olduğu gözlendi (p<0.05). Deneme grubundaki ağrı skorlarının kontrol grubundaki T2 (p<0.05), T4 (p<0.01) ve T6 (p<0.01) zamanlarına göre daha düşük olduğu tespit edildi. Sonuç olarak, ovariohisterektomi yapılan köpeklerde intraperitoneal ve insizyonel sprey lidokain uygulamasının postoperatif ağrı yönetiminde etkili olduğu ifade edilmektedir.

Keywords

• Lidokain
• TOS
• TAS
• OSI
• ağrı

Sprayed Intraperitoneal and Incisional Lidocaine Reduces Early Postoperative Pain After Ovariohysterectomy in Dogs

Abstract

In the present study, it was aimed to investigate the effect of intraperitoneal and incisional sprayed lidocaine on postoperative stress, oxidative stress and pain in dogs undergoing ovariohysterectomy. The control group (n=12) received intraperitoneal and incisional sprayed 0.9 % NaCl, whereas the preparation of lidocaine (8.8 mg/kg) with the equal volume of 0.9 % NaCl following calculation of the individual doses was sprayed in the experiment group (n=12). Modified Melbourne pain assessment was performed before sedation (T), at the end of surgery (T0), 30 minutes after surgery (T½) and at 1 (T1), 2 (T2), 4 (T4) and 6 (T6) hours after the end of surgery. Venous blood samples were collected to measure the concentrations of serum cortisol, total oxidant status (TOS) and total antioxidant status (TAS) at related times. Oxidative stress index (OSI) was calculated by the determination of the rate of TOS/TAS. The concentrations of cortisol, TAS and OSI did not show any significant difference between groups (p > 0.05). The concentration of TOS was the highest at T1 in the experiment group (p<0.05). The pain scores in the experiment group were lower (p<0.05) than those detected at T2 (p<0.05), T4 (p<0.01) and T6 (p<0.01) in the control group. In conclusion, it was stated that the treatment of intraperitoneal and incisional sprayed lidocaine is effective on postoperative pain management in dogs undergoing ovariohysterectomy.

Keywords

• Lidocaine
• TOS
• TAS
• OSI
• Pain

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