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Novel thiazole/ethyl thiazole carboxylate-acetamide derivatives and their cytotoxic effect evaluation

Year 2024, Volume: 17 Issue: 2, 104 - 116, 30.06.2024
https://doi.org/10.30607/kvj.1430771

Abstract

In this study, the main goal is to determine the anticancer compound(s) that can be used against A549 non-small lung epithelial carcinoma, Caco-2 colon carcinoma, and SHSY-5Y neuroblastoma cells with high selectivity. For this purpose, our study group synthesized two similar acetamide series: four compounds (3a–3d), including thiazole, and four compounds (3e–3h), including ethyl (4-methyl-thiazol-5-yl)carboxylate. The structural analyses of eight compounds were identified by HRMS, 1H-NMR, and 13C-NMR. After approving the purity, their anticancer profiles were evaluated against above cancer cells, and the cytotoxicity effect was also tested against NIH/3T3 fibroblast cells. Meanwhile, ADME and DFT calculations indicated that compounds have good ADME profiles and chemical stability. Among the targeted compounds, compound 3g exhibits greater stability. In chemical systems, stability is important because it represents the energy balance within a molecule. The results showed that compounds have significant impact on SHSY-5Y cells with higher selectivity than other cells. The combination of ester groups on thiazole and thiazoline (compound 3g) was found to be significantly more effective than doxorubicin and highly selective on SHSY-5Y cells than healthy cells. Besides that, combination of thiazole and triazole (3d and 3h) decreased antiproliferative activity in three cancer cells while increasing cytotoxicity in healthy cells. This study suggests that future perspectives in studies regarding the treatments of neuroblastoma and its related diseases of ethyl 2-acetamido-4-methylthiazole-5-carboxylate and thiazoline combination are encouraging.

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Yeni tiyazol/etil tiyazol karboksilat-asetamid türevleri ve bunların sitotoksik etkisinin değerlendirilmesi

Year 2024, Volume: 17 Issue: 2, 104 - 116, 30.06.2024
https://doi.org/10.30607/kvj.1430771

Abstract

Bu çalışmada A549 küçük olmayan akciğer epitelyal karsinomu, Caco-2 kolon karsinomu ve SHSY-5Y nöroblastoma hücrelerine karşı kullanılabilecek yüksek seçiciliğe sahip antikanser bileşik(ler)in belirlenmesi temel amaçtır. Bu amaçla çalışma grubumuz tiyazol içeren dört bileşik (3a-3d) ve etil (4-metil-tiyazol-5-il)karboksilat içeren dört bileşik (3e-3h) şeklinde benzer iki asetamit serisi sentezledi. Sekiz bileşiğin yapısal analizleri HRMS, 1H-NMR ve 13C-NMR ile tanımlandı. Saflık onaylandıktan sonra yukarıdaki kanser hücrelerine karşı antikanser profilleri değerlendirildi ve ayrıca NIH/3T3 fibroblast hücrelerine karşı sitotoksisite etkisi test edildi. Bu arada ADME ve DFT hesaplamaları bileşiklerin iyi ADME profillerine ve kimyasal stabiliteye sahip olduğu belirlendi. Hedeflenen bileşikler arasında bileşik 3g daha fazla stabilite sergilemektedir. Kimyasal sistemlerde stabilite önemlidir çünkü bir molekül içindeki enerji dengesini temsil eder. Sonuçlar, bileşiklerin SHSY-5Y hücreleri üzerinde diğer hücrelere göre daha seçici bir etkiye sahip olduğunu gösterdi. Tiyazol üzerindeki ester grubu ile tiyazolidin (bileşik 3g) kombinasyonunun doksorubisinden anlamlı derecede etkili olduğu ve SHSY-5Y hücreleri üzerinde sağlıklı hücrelere göre oldukça seçici olduğu bulundu. Bunun yanı sıra, tiyazol-triazol kombinasyonu (3d ve 3h) üç kanser hücresinde de antiproliferatif aktiviteyi azaltırken, sağlıklı hücrede sitotoksisiteyi arttırdı. Bu çalışma ile nöroblastoma ve bununla ilişkili hastalıkların tedavisine ilişkin çalışmalarda etil 2-asetamido-4-metiltiyazol-5-karboksilat ve tiyazolin kombinasyonunun gelecekteki yaklaşımlar için ümit verici olduğunu ileri sürmektedir.

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There are 66 citations in total.

Details

Primary Language English
Subjects Veterinary Biochemistry, Veterinary Pharmacology
Journal Section RESEARCH ARTICLE
Authors

Asaf Evrim Evren 0000-0002-8651-826X

Sam Dawbaa 0000-0001-7001-0739

Demokrat Nuha 0000-0002-7271-6791

Aybüke Züleyha Kaya 0009-0002-1614-2380

Zerrin Canturk 0000-0001-7709-4285

Leyla Yurttaş 0000-0002-0957-6044

Early Pub Date June 12, 2024
Publication Date June 30, 2024
Submission Date February 3, 2024
Acceptance Date May 28, 2024
Published in Issue Year 2024 Volume: 17 Issue: 2

Cite

APA Evren, A. E., Dawbaa, S., Nuha, D., Kaya, A. Z., et al. (2024). Novel thiazole/ethyl thiazole carboxylate-acetamide derivatives and their cytotoxic effect evaluation. Kocatepe Veterinary Journal, 17(2), 104-116. https://doi.org/10.30607/kvj.1430771
AMA Evren AE, Dawbaa S, Nuha D, Kaya AZ, Canturk Z, Yurttaş L. Novel thiazole/ethyl thiazole carboxylate-acetamide derivatives and their cytotoxic effect evaluation. kvj. June 2024;17(2):104-116. doi:10.30607/kvj.1430771
Chicago Evren, Asaf Evrim, Sam Dawbaa, Demokrat Nuha, Aybüke Züleyha Kaya, Zerrin Canturk, and Leyla Yurttaş. “Novel thiazole/Ethyl Thiazole Carboxylate-Acetamide Derivatives and Their Cytotoxic Effect Evaluation”. Kocatepe Veterinary Journal 17, no. 2 (June 2024): 104-16. https://doi.org/10.30607/kvj.1430771.
EndNote Evren AE, Dawbaa S, Nuha D, Kaya AZ, Canturk Z, Yurttaş L (June 1, 2024) Novel thiazole/ethyl thiazole carboxylate-acetamide derivatives and their cytotoxic effect evaluation. Kocatepe Veterinary Journal 17 2 104–116.
IEEE A. E. Evren, S. Dawbaa, D. Nuha, A. Z. Kaya, Z. Canturk, and L. Yurttaş, “Novel thiazole/ethyl thiazole carboxylate-acetamide derivatives and their cytotoxic effect evaluation”, kvj, vol. 17, no. 2, pp. 104–116, 2024, doi: 10.30607/kvj.1430771.
ISNAD Evren, Asaf Evrim et al. “Novel thiazole/Ethyl Thiazole Carboxylate-Acetamide Derivatives and Their Cytotoxic Effect Evaluation”. Kocatepe Veterinary Journal 17/2 (June 2024), 104-116. https://doi.org/10.30607/kvj.1430771.
JAMA Evren AE, Dawbaa S, Nuha D, Kaya AZ, Canturk Z, Yurttaş L. Novel thiazole/ethyl thiazole carboxylate-acetamide derivatives and their cytotoxic effect evaluation. kvj. 2024;17:104–116.
MLA Evren, Asaf Evrim et al. “Novel thiazole/Ethyl Thiazole Carboxylate-Acetamide Derivatives and Their Cytotoxic Effect Evaluation”. Kocatepe Veterinary Journal, vol. 17, no. 2, 2024, pp. 104-16, doi:10.30607/kvj.1430771.
Vancouver Evren AE, Dawbaa S, Nuha D, Kaya AZ, Canturk Z, Yurttaş L. Novel thiazole/ethyl thiazole carboxylate-acetamide derivatives and their cytotoxic effect evaluation. kvj. 2024;17(2):104-16.

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