Research Article
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Effect of Combination of Hypericum perforatum, Calendula officinalis and Aloe vera Plant Extracts on Incisional Wound Healing

Year 2022, , 161 - 168, 31.12.2022
https://doi.org/10.24998/maeusabed.1195179

Abstract

Today, patients and health professionals are turning to innovative approaches due to the lack of success in treating chronic wounds. This study aimed to investigate the effect of a mixture of Hypericum perforatum histopathologically, Calendula officinalis, and Aloe vera plant extracts on incisional wound healing. A total of 14 rats, 7 rats, were used in each group. The groups were divided into experimental and control. While daily wound care was performed with an herbal extract mixture in the experimental group, sterile saline was used for daily wound care in the control group. During the study, wound surface area measurement, macroscopic evaluation, and histopathological examination were performed in both groups. According to research findings, the control group's wound-healing process is shorter. Histopathological analyses revealed that wound healing was completed on day 21.

Supporting Institution

Burdur Mehmet Akif Ersoy Üniversitesi Bilimsel Araştırma Projeleri Kordinatörlüğü

Project Number

0593-YL-19

Thanks

-

References

  • Altan, A., Damlar, İ., Aras, M.H., Alparslan, C., 2015. Sarı kantaronun (hypericum perforatum) yara iyileşmesi üzerine etkisi. Çukurova Üniversitesi Arşiv Kaynak Tarama Dergisi, 24(4), 578-591.
  • Ashkani-Esfahani, S., Khoshneviszadeh, M., Noorafshan, A., Miri, R., Rafiee, S., Hemyari, K., Kardeh, S., Hosseinabadi, O.K., Fani1, D., Faridi, E., 2019. The healing effect of plantago major and aloe vera mixture in excisional full thickness skin wounds: Stereological Study. World J Surg., 8(1), 51.
  • Attah, M.O., Jacks, T.W., Jacob, A., Eduitem, O., John, B., 2016. The effect of aloe vera (linn) on cutaneous wound healing and wound contraction rate in adult rabbits. NJMBS., 5(3).
  • Budovsky, A., Yarmolinsky, L., Ben‐Shabat, S., 2015. Effect of medicinal plants on wound healing. Wound Repair Regen., 23(2), 171-183.
  • Erçetin, T., Şenol, F., Orhan, I., Toker, G., 2012. Comparative assessment of antioxidant and cholinesterase inhibitory properties of the marigold extracts from Calendula arvensis L. and Calendula officinalis L. Ind Crops Prod., 36(1), 203–208.
  • Gunasekaran, S., Nayagam, A.A.J., Natarajan, R., 2020. Wound healing potentials of herbal ointment containing Calendula officinalis Linn. on the alteration of immunological markers and biochemical parameters in excision wounded animals. Clin. Phytoscience, 6(1), 1-8.
  • Hashemi, S.A., Madani, S.A., Abediankenari, S., 2015. The review on properties of aloe vera in healing of cutaneous wounds. Biomed Res. Int.,1-6.
  • Kısacık, G.Ö., 2015. İskemik yaraların iyileşmesinde kudret narı ekstraktı ile yapılan pansumanın, saf zeytinyağı, nitrofurazon ve serum fizyolojik kullanılarak yapılan pansumanlara göre etkinliğinin incelenmesi. Doktora Tezi, Hemşirelik Esasları Anabilim Dalı Programı, Ege Üniversitesi Sağlık Bilimleri Enstitüsü, İzmir.
  • Koga, A.Y., Felix, J.C., Silvestre, R.G.M., Lipinski, L.C., Carletto, B., Kawahara, F.A., Pereira, A.V., 2020. Evaluation of wound healing effect of alginate film containing Aloe vera gel and cross-linked with zinc chloride. Acta Cir. Bras., 35(5), e202000507.
  • Kundarto, W., Pangesti, K.A.Y., Shabrina, F., Sasongko, H., 2020. Wound healing activity of skin incision and skin burn from spray gel formula contains combination of banana stem (Musa acuminata Colla) and Aloe vera ethanol extracts on mice. In IOP Conf. Ser.: Mater. Sci. Eng., 858(1), 012027.
  • Nayak, S.B., Işık, K., Marshall, J.R., 2017. Wound-healing potential of oil of Hypercium perforatum in excision wounds of male Sprague Dawley rats. Adv Wound Care., 6(12), 401-406.
  • Oryan, A., Mohammadalipour, A., Moshiri, A., Tabandeh, M.R., 2016. Topical application of aloe vera accelerated wound healing, modeling, and remodeling: an experimental study. Ann. Plast. Surg., 77(1), 37-46.
  • Özkorkmaz, E.G., Özay, Y., 2009. Yara iyileşmesi ve yara iyileşmesinde kullanılan bazı bitkiler. Turk J Med Sci., 2(2), 63-67.
  • Prisacaru, A.I., Andritoiu, C.V., Andriescu, C., Havarneanu, E.C., Popa, M., Motoc, A.G.M., Sava, A., (2013). Evaluation of the wound-healing effect of a novel hypericum perforatum ointment in skin ınjury. Rom J Morphol Embryo., 54(4), 1053-1059.
  • Rahman, M.T., Hasan, M., Hossain, M.T., Islam, M.S., Rahman, M.A., Alam, M.R., Juyena, N.S., 2020. Differential efficacies of marigold leaves and turmeric paste on the healing of the incised wound in sheep. J. Adv. Vet. Anim. Res.,7(4), 750-757.
  • Saini, S., Dhiman, A., Nanda, S., 2016. Traditional Indian medicinal plants with potential wound healing activity: a review. Int. J. Pharm. Sci. Res., 7(5), 1809-1819.
  • Sançar, B., Canbulat, Ş., İlhan, S.E., 2017. Yara bakımında kullanılan bitkisel yöntemler ve hemşirelik. Türkiye Klinikleri J Intern Med Nurs-Special Topics., 3(2), 116-124.
  • Sarı, A.O., Oğuz, B., Bilgiç, A., Tort, N., Güvensen, A., Şenol, S.G., 2010. Ege ve güney marmara bölgelerinde halk ilacı olarak kullanılan bitkiler. AARI, 20(2), 1-21.
  • Süntar, İ.P., Akkol, E.K., Yılmazer, D., Baykal, T., Kırmızıbekmez, H., Alper, M., Yeşilada, E., 2010. Investigations on the in vivo wound healing potential of hypericum perforatum l. J. Ethnopharmacol., 127(2), 468-477.
  • Türsen, B., Türsen, Ü., 2014. Dermatolojide Aloe vera. Dermatoloji Akademisi Derneği, 4, 1-11.

Hypericum perforatum, calendula officinalis ve aloe vera bitki ekstraktlarının kombinasyonunun insizyonel yara iyileşmesine etkisi

Year 2022, , 161 - 168, 31.12.2022
https://doi.org/10.24998/maeusabed.1195179

Abstract

Günümüzde hastalar ve sağlık profesyonelleri, kronik yaraların bakım ve tedavisinde başarı sağlanamaması nedeniyle yenilikçi yaklaşımlara yönelmektedir. Bu çalışmada, Hypericum perforatum, Calendula officinalis ve Aloe vera bitki ekstraktlarının bir karışımının insizyonel yara iyileşmesi üzerine etkisinin histopatolojik olarak incelenmesi amaçlanmıştır. Çalışmada her grupta 7 sıçan olmak üzere toplam 14 sıçan kullanılmıştır. Gruplar deneysel ve kontrol olarak ikiye ayrıldı. Deney grubunda bitkisel ekstre karışımı ile günlük yara bakımı yapılırken, kontrol grubunda günlük yara bakımı için steril salin kullanılmıştır. Çalışma süresince her iki grupta da yara yüzey alanı ölçümü, makroskopik değerlendirme ve histopatolojik inceleme yapıldı. Araştırma bulgularına göre kontrol grubunda yara iyileşme süreci daha kısadır. Histopatolojik incelemelerde yara iyileşmesinin 21. günde tamamlandığı gözlendi.

Project Number

0593-YL-19

References

  • Altan, A., Damlar, İ., Aras, M.H., Alparslan, C., 2015. Sarı kantaronun (hypericum perforatum) yara iyileşmesi üzerine etkisi. Çukurova Üniversitesi Arşiv Kaynak Tarama Dergisi, 24(4), 578-591.
  • Ashkani-Esfahani, S., Khoshneviszadeh, M., Noorafshan, A., Miri, R., Rafiee, S., Hemyari, K., Kardeh, S., Hosseinabadi, O.K., Fani1, D., Faridi, E., 2019. The healing effect of plantago major and aloe vera mixture in excisional full thickness skin wounds: Stereological Study. World J Surg., 8(1), 51.
  • Attah, M.O., Jacks, T.W., Jacob, A., Eduitem, O., John, B., 2016. The effect of aloe vera (linn) on cutaneous wound healing and wound contraction rate in adult rabbits. NJMBS., 5(3).
  • Budovsky, A., Yarmolinsky, L., Ben‐Shabat, S., 2015. Effect of medicinal plants on wound healing. Wound Repair Regen., 23(2), 171-183.
  • Erçetin, T., Şenol, F., Orhan, I., Toker, G., 2012. Comparative assessment of antioxidant and cholinesterase inhibitory properties of the marigold extracts from Calendula arvensis L. and Calendula officinalis L. Ind Crops Prod., 36(1), 203–208.
  • Gunasekaran, S., Nayagam, A.A.J., Natarajan, R., 2020. Wound healing potentials of herbal ointment containing Calendula officinalis Linn. on the alteration of immunological markers and biochemical parameters in excision wounded animals. Clin. Phytoscience, 6(1), 1-8.
  • Hashemi, S.A., Madani, S.A., Abediankenari, S., 2015. The review on properties of aloe vera in healing of cutaneous wounds. Biomed Res. Int.,1-6.
  • Kısacık, G.Ö., 2015. İskemik yaraların iyileşmesinde kudret narı ekstraktı ile yapılan pansumanın, saf zeytinyağı, nitrofurazon ve serum fizyolojik kullanılarak yapılan pansumanlara göre etkinliğinin incelenmesi. Doktora Tezi, Hemşirelik Esasları Anabilim Dalı Programı, Ege Üniversitesi Sağlık Bilimleri Enstitüsü, İzmir.
  • Koga, A.Y., Felix, J.C., Silvestre, R.G.M., Lipinski, L.C., Carletto, B., Kawahara, F.A., Pereira, A.V., 2020. Evaluation of wound healing effect of alginate film containing Aloe vera gel and cross-linked with zinc chloride. Acta Cir. Bras., 35(5), e202000507.
  • Kundarto, W., Pangesti, K.A.Y., Shabrina, F., Sasongko, H., 2020. Wound healing activity of skin incision and skin burn from spray gel formula contains combination of banana stem (Musa acuminata Colla) and Aloe vera ethanol extracts on mice. In IOP Conf. Ser.: Mater. Sci. Eng., 858(1), 012027.
  • Nayak, S.B., Işık, K., Marshall, J.R., 2017. Wound-healing potential of oil of Hypercium perforatum in excision wounds of male Sprague Dawley rats. Adv Wound Care., 6(12), 401-406.
  • Oryan, A., Mohammadalipour, A., Moshiri, A., Tabandeh, M.R., 2016. Topical application of aloe vera accelerated wound healing, modeling, and remodeling: an experimental study. Ann. Plast. Surg., 77(1), 37-46.
  • Özkorkmaz, E.G., Özay, Y., 2009. Yara iyileşmesi ve yara iyileşmesinde kullanılan bazı bitkiler. Turk J Med Sci., 2(2), 63-67.
  • Prisacaru, A.I., Andritoiu, C.V., Andriescu, C., Havarneanu, E.C., Popa, M., Motoc, A.G.M., Sava, A., (2013). Evaluation of the wound-healing effect of a novel hypericum perforatum ointment in skin ınjury. Rom J Morphol Embryo., 54(4), 1053-1059.
  • Rahman, M.T., Hasan, M., Hossain, M.T., Islam, M.S., Rahman, M.A., Alam, M.R., Juyena, N.S., 2020. Differential efficacies of marigold leaves and turmeric paste on the healing of the incised wound in sheep. J. Adv. Vet. Anim. Res.,7(4), 750-757.
  • Saini, S., Dhiman, A., Nanda, S., 2016. Traditional Indian medicinal plants with potential wound healing activity: a review. Int. J. Pharm. Sci. Res., 7(5), 1809-1819.
  • Sançar, B., Canbulat, Ş., İlhan, S.E., 2017. Yara bakımında kullanılan bitkisel yöntemler ve hemşirelik. Türkiye Klinikleri J Intern Med Nurs-Special Topics., 3(2), 116-124.
  • Sarı, A.O., Oğuz, B., Bilgiç, A., Tort, N., Güvensen, A., Şenol, S.G., 2010. Ege ve güney marmara bölgelerinde halk ilacı olarak kullanılan bitkiler. AARI, 20(2), 1-21.
  • Süntar, İ.P., Akkol, E.K., Yılmazer, D., Baykal, T., Kırmızıbekmez, H., Alper, M., Yeşilada, E., 2010. Investigations on the in vivo wound healing potential of hypericum perforatum l. J. Ethnopharmacol., 127(2), 468-477.
  • Türsen, B., Türsen, Ü., 2014. Dermatolojide Aloe vera. Dermatoloji Akademisi Derneği, 4, 1-11.
There are 20 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Article
Authors

Sultan Kaya 0000-0002-4863-7188

Şevkinaz Doğan 0000-0001-6180-7586

Mahmut Ateş 0000-0002-1470-2551

Project Number 0593-YL-19
Publication Date December 31, 2022
Submission Date October 27, 2022
Published in Issue Year 2022

Cite

APA Kaya, S., Doğan, Ş., & Ateş, M. (2022). Effect of Combination of Hypericum perforatum, Calendula officinalis and Aloe vera Plant Extracts on Incisional Wound Healing. Mehmet Akif Ersoy University Journal of Health Sciences Institute, 10(3), 161-168. https://doi.org/10.24998/maeusabed.1195179
AMA Kaya S, Doğan Ş, Ateş M. Effect of Combination of Hypericum perforatum, Calendula officinalis and Aloe vera Plant Extracts on Incisional Wound Healing. Mehmet Akif Ersoy University Journal of Health Sciences Institute. December 2022;10(3):161-168. doi:10.24998/maeusabed.1195179
Chicago Kaya, Sultan, Şevkinaz Doğan, and Mahmut Ateş. “Effect of Combination of Hypericum Perforatum, Calendula Officinalis and Aloe Vera Plant Extracts on Incisional Wound Healing”. Mehmet Akif Ersoy University Journal of Health Sciences Institute 10, no. 3 (December 2022): 161-68. https://doi.org/10.24998/maeusabed.1195179.
EndNote Kaya S, Doğan Ş, Ateş M (December 1, 2022) Effect of Combination of Hypericum perforatum, Calendula officinalis and Aloe vera Plant Extracts on Incisional Wound Healing. Mehmet Akif Ersoy University Journal of Health Sciences Institute 10 3 161–168.
IEEE S. Kaya, Ş. Doğan, and M. Ateş, “Effect of Combination of Hypericum perforatum, Calendula officinalis and Aloe vera Plant Extracts on Incisional Wound Healing”, Mehmet Akif Ersoy University Journal of Health Sciences Institute, vol. 10, no. 3, pp. 161–168, 2022, doi: 10.24998/maeusabed.1195179.
ISNAD Kaya, Sultan et al. “Effect of Combination of Hypericum Perforatum, Calendula Officinalis and Aloe Vera Plant Extracts on Incisional Wound Healing”. Mehmet Akif Ersoy University Journal of Health Sciences Institute 10/3 (December 2022), 161-168. https://doi.org/10.24998/maeusabed.1195179.
JAMA Kaya S, Doğan Ş, Ateş M. Effect of Combination of Hypericum perforatum, Calendula officinalis and Aloe vera Plant Extracts on Incisional Wound Healing. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2022;10:161–168.
MLA Kaya, Sultan et al. “Effect of Combination of Hypericum Perforatum, Calendula Officinalis and Aloe Vera Plant Extracts on Incisional Wound Healing”. Mehmet Akif Ersoy University Journal of Health Sciences Institute, vol. 10, no. 3, 2022, pp. 161-8, doi:10.24998/maeusabed.1195179.
Vancouver Kaya S, Doğan Ş, Ateş M. Effect of Combination of Hypericum perforatum, Calendula officinalis and Aloe vera Plant Extracts on Incisional Wound Healing. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2022;10(3):161-8.