Immunohistochemical Determination of the Matrix Metalloproteinase-2 and -7 Expression in Transmissible Venereal Tumor in Dogs

Year 2018, Volume: 3 Issue: 2, 106 - 110, 30.12.2018

Özlem Özmen , Ezgi Ogus

https://doi.org/10.24880/maeuvfd.481960

Cited By: 1

Abstract

Transmissible venereal
tumor (TVT) is a sexually transmitted, naturally occurring tumor of the canine
family and often occurs in tropical and subtropical countries. The matrix metalloproteinases
(MMPs) are endogenous proteases accountable for the degradation of
extracellular matrix (ECM) components, such as collagen and other proteins including
the basement membrane. MMPs play a vital role in the tumor metastasis and
angiogenesis. Both MMP-2 and -7 strongly associated with the invasion and
metastasis of different cancer types. This study aims to investigate the MMP-2
and -7 expression in naturally occurring TVT in 20 dogs using immunohistochemical
methods. Immunohistochemically, we observed increased MMP-2 and -7 expressions in
tumor cells. In addition, a positive correlation was determined between the tumor
size and immunoexpressions of the markers indicating
that both MMP-2 and -7 participate in the
TVT pathogenesis.

Keywords

dog, pat

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