Research Article
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Year 2019, Volume 4, Issue 1, 8 - 13, 30.06.2019
https://doi.org/10.24880/maeuvfd.523108

Abstract

References

  • 1. Soulsby EJL, Helminths A. Protozoa of Domesticated Animals. 6th ed. UK: Baillière Tindall; 1982.2. 2. Ranucci S, Mughetti L, Ambrosi M, Grelloni V. Rilievi ematochimici, anatomo-istopatologici e parassitologici in ovini infetti da dicroceliosi. Rev Zoo Vet. 1981; 9: 173–175. DOI: 3. Otranto D & Traversa D. A review of dicrocoeliosis of ruminants including recent advances in the diagnosis and treatment. Vet Parasitol. 2002; 107(4): 317–335. DOI: 10.1016/S0304-4017(02)00121-8.4. Manga-González MY, Ferreras MC, Campo RC, González-Lanza Pérez V, García-Marín JF. Hepatic marker enzymes, biochemical parameters and pathological effects in lambs experimentally infected with Dicrocoelium dendriticum. Parasitol Res. 2004; 93: 344–355. DOI: 10.1007/s00436-004-1128-2.5. Kavanagh C, Shaw S, Webster CR. Coagulation in hepatobiliary disease. J Vet Emerg Crit Care. 2011; 21(6): 589–604. DOI: 10.1111/j.1476-4431.2011.00691.x.6. Anstee QM, Wright M, Goldin R, Thursz MR. Parenchymal extinction: coagulation and hepatic fibrogenesis. Clin Liver Dis. 2009; 13(1): 117–126. DOI: 10.1016/j.cld.2008.09.013.7. Lisman T, Caldwell SH, Burroughs AK, Northup PG, Senzolo M, Stravitz RT. Hemostasis and thrombosis in patients with liver disease: the ups and downs. J Hepatol. 2010; 53(2): 362–371. DOI: 10.1016/j.jhep.2010.01.042.8. Manga-González MY, Ferreras MC. Dicrocoeliidae family: major species causing veterinary diseases. Adv Exp Med Biol. 2014; 766: 393–428. DOI: 10.1007/978-1-4939-0915-5_12.9. Coma SM, Bargues MD. Human liver flukes: a review. Res and Rev Parasito. 1997; 57: 145–218.10. Coma SM, Agramunt VH, Valero MA. Neurological and ocular fascioliasis in humans. Adv Parasitol. 2014; 84: 27–149. DOI: 10.1016/B978-0-12-800099-1.00002-8.11. Wilhelmi MH, Tiede A, Teebken OE, Bisdas T, Haverich A, Mischke R. Ovine blood: Establishment of a list of reference values relevant for blood coagulation in sheep. ASAIO Journal. 2012; 58(1): 79–82. DOI: 10.1097/MAT.0b013e31823a5414.12. Naeemipour M, Hashemitabar GR, Dastjerdi K, Mojaver MJ, Mohammadi HR. Comparison of Fecal Egg Counts and ELISA for the diagnosis of Dicrocoelium Dendriticum infection. Pol J Vet Sci. 2016; 19(3): 573–580. DOI: 10.1515/pjvs-2016-0072.13. Roepstorff A & Nansen P. Epidemiology, diagnosis and control of helminth parasites of swine. Rome: FAO Animal Health Manual; 1998. 14. Torre-Escudero ER, Manzano-Román M, Siles-Lucas R, Pérez-Sánchez JC, Moyano I, Barrera AO. Molecular and functional characterization of a Schistosoma bovis annexin: fibrinolytic and anticoagulant activity. Vet Parasitol. 2012, 184: 25–36. DOI: 10.1016/j.vetpar.2011.08.013.15. Bernal D, Trelis M, Montaner S, Cantalapiedra F, Galiano A, Hackenberg M. Surface analysis of Dicrocoelium dendriticum: The molecular characterization of exosomes reveals the presence of miRNAs. J Proteomics. 2014; 105: 232–241. DOI: 10.1016/j.jprot.2014.02.012.16. Mammen EF. Coagulation defects in liver disease. Med Clin North Am. 1994; 78(3): 545–554. DOI: 10.1016/S0025-7125(16)30146-8.17. Amitrano L, Guardascione MA, Brancaccio V, Balzano A. Coagulation disorders in liver disease. Semin. Liver Dis. 2002; 22(1): 83–96. DOI: 10.1055/s-2002-23205.18. Caldwell SH, Hoffman M, Lisman T, Macik BG, Northup PG, Reddy KR. Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management. Hepatol. 2006; 44(4): 1039–1046. DOI: 10.1002/hep.21303.19. Theodoridis Y, Duncan JL, Maclean JM, Himonas CA. Pathophysiological studies on Dicrocoelium dendriticum infection in sheep. Vet Parasitol. 1991; 39: 61–66. DOI:10.1016/0304-4017(91)90062-Z20. Rojo-Vázquez FA, Meana A, Valcárcel F, Martínez-Valladares M. Update on trematode infections in sheep. Vet Parasitol. 2012; 189(1): 15–38. DOI: 10.1016/j.vetpar.2012.03.029.21. Abdouslam OE, Al-ızzi SA, Al-bassam LS, Azwai SM. Effect of anthelmintic treatment on haematological and coagulation parameters in Ilamas (Lama glama) Infected with gastrointestinal parasites. J Camel Pract Res. 2003; 10(2):149–152.22. Schetters TP, Kleuskens JAGM, Crommert VJ, Leeuw PWJ, Finizio AL, Gorenflot A. Systemic inflammatory responses in dogs experimentally infected with Babesia canis; a haematological study. Vet Parasitol. 2009; 162(1): 7–15. DOI: 10.1016/j.vetpar.2009.02.012.23. Boehm TK, Sojar H, De Nardin E. Concentration-dependent effect of fibrinogen on IgG-specific antigen binding and phagocytosis. Cellular Immuno. 2010; 263: 41–48. DOI: 10.1016/j.cellimm.2010.02.014.24. Rafaj BR, Kuleš J, Selanec J, Vrkić N, Zovko V, Zupančič M. Markers of coagulation activation, endothelial stimulation, and inflammation in dogs with babesiosis. J Vet Intern Med. 2013; 27(5): 1172–1178. DOI: 10.1111/jvim.12146.25. Esmon CT, Xu J, Lupu F. Innate immunity and coagulation. J Thromb Haemost. 2011; 9(1): 182–188. DOI: 10.1111/j.1538-7836.2011.04323.x.26. Gånheim C, Hulten C, Carlsson U, Kindahl H, Niskanen R, Waller KP. The acute phase response in calves experimentally infected with bovine viral diarrhoea virus and/or Mannheimia haemolytica. Zoonoses Public Health. 2003; 50(4): 183–190. DOI: 10.1046/j.1439-0450.2003.00658.x.27. Van Der Ree AM, Mutapi F. The helminth parasite proteome at the host–parasite interface–Informing diagnosis and control. Exp Parasitol. 2015; 157: 48–58. DOI: 10.1016/j.exppara.2015.06.007.28. Knox MR, Besier RB, Le Jambre LF, Kaplan RM, Torres-Acosta JFJ, Miller J. Novel approaches for the control of helminth parasites of livestock VI: Summary of discussions and conclusions. Vet Parasitol. 2012; 186(1): 143–149. DOI: 10.1016/j.vetpar.2011.11.054.29. Colditz IG. Effects of the immune system on metabolism: implications for production and disease resistance in livestock. Livest Sci. 2002; 75(3): 257–268. DOI: 10.1016/S0301-6226(01)00320-7.30. Beck MA, Goater CP, Colwell DD. Comparative recruitment, morphology and reproduction of a generalist trematode, Dicrocoelium dendriticum, in three species of host. Parasitology. 2015; 142(10): 1297–1305. DOI:10.1017/S0031182015000621.31. Joachim A, Ali S, Daugschies A. Fasciola hepatica alters coagulation parameters in sheep plasma in vivo and in vitro. Parasitol Res. 2002; 89(1): 53–58. DOI: 10.1007/s00436-002-0723-3.32. Matula SJM, Plasenzotti R, Spiel A, Quehenberger P, Jilma B. Interspecies differences in coagulation profile. Thromb Haemost. 2008; 100(03): 397–404. 33. Gardiner C, Adcock DM, Carrington LR, Kottke MK, Marlar RA, McGlasson DL. Protocol for the Evaluation, Validation, and Implementation of Coagulometers; Approved Guideline H57-A. Clinical and Laboratory Standards Institute. 2008.34. Schulman S, Elbazi R, Zondag M, O'Donnell M. Clinical factors influencing normalization of prothrombin time after stopping warfarin: a retrospective cohort study. Thromb J. 2008; 6(1): 15. DOI: 10.1186/1477-9560-6-15.

Evaluation of albendazole treatment on coagulation profile in sheep naturally infected with Dicrocoelium dentriticum

Year 2019, Volume 4, Issue 1, 8 - 13, 30.06.2019
https://doi.org/10.24880/maeuvfd.523108

Abstract

The aim of the present study was to evaluate the selected coagulation profile parameters in sheep naturally infected with Dicrocoeliumdentriticum and effects of albendazole treatmentFor this reason, 34 merino sheep, aged between 1 and 3 years, naturally infected with Dicrocoeliumdentriticumwere enrolled in the present study. Plasma and stool samples were withdrawn from each animal before and 10 days after treatment and egg per gram feces were evaluated with Mc Master technique. Prothrombin time activated partial thromboplastin time and fibrinogen levels were determined by semiautomated coagulometer by using commercial test kits before and 10 days after treatment.Noticeable clinical recovery was detected in all animals after albendazole treatment. There were significant differences on Prothrombin time and fibrinogen levels a p value of (p<0.001) between treatment intervals. In conclusion, this is the first study for selected coagulation parameters before and after albendazole treatment for ovine patients naturally infected with Dicrocoeliumdentriticum. It should be mentioned that the treatment resulted in lower prothrombin time and fibrinogen values, suggesting that dicrocoeliasis might alter coagulation profile and possibly induce an acute phase response. Furthermore, the clinical relevance in ovine medicine and related results possibly interacting to human medicine has to be determined by future studies.

References

  • 1. Soulsby EJL, Helminths A. Protozoa of Domesticated Animals. 6th ed. UK: Baillière Tindall; 1982.2. 2. Ranucci S, Mughetti L, Ambrosi M, Grelloni V. Rilievi ematochimici, anatomo-istopatologici e parassitologici in ovini infetti da dicroceliosi. Rev Zoo Vet. 1981; 9: 173–175. DOI: 3. Otranto D & Traversa D. A review of dicrocoeliosis of ruminants including recent advances in the diagnosis and treatment. Vet Parasitol. 2002; 107(4): 317–335. DOI: 10.1016/S0304-4017(02)00121-8.4. Manga-González MY, Ferreras MC, Campo RC, González-Lanza Pérez V, García-Marín JF. Hepatic marker enzymes, biochemical parameters and pathological effects in lambs experimentally infected with Dicrocoelium dendriticum. Parasitol Res. 2004; 93: 344–355. DOI: 10.1007/s00436-004-1128-2.5. Kavanagh C, Shaw S, Webster CR. Coagulation in hepatobiliary disease. J Vet Emerg Crit Care. 2011; 21(6): 589–604. DOI: 10.1111/j.1476-4431.2011.00691.x.6. Anstee QM, Wright M, Goldin R, Thursz MR. Parenchymal extinction: coagulation and hepatic fibrogenesis. Clin Liver Dis. 2009; 13(1): 117–126. DOI: 10.1016/j.cld.2008.09.013.7. Lisman T, Caldwell SH, Burroughs AK, Northup PG, Senzolo M, Stravitz RT. Hemostasis and thrombosis in patients with liver disease: the ups and downs. J Hepatol. 2010; 53(2): 362–371. DOI: 10.1016/j.jhep.2010.01.042.8. Manga-González MY, Ferreras MC. Dicrocoeliidae family: major species causing veterinary diseases. Adv Exp Med Biol. 2014; 766: 393–428. DOI: 10.1007/978-1-4939-0915-5_12.9. Coma SM, Bargues MD. Human liver flukes: a review. Res and Rev Parasito. 1997; 57: 145–218.10. Coma SM, Agramunt VH, Valero MA. Neurological and ocular fascioliasis in humans. Adv Parasitol. 2014; 84: 27–149. DOI: 10.1016/B978-0-12-800099-1.00002-8.11. Wilhelmi MH, Tiede A, Teebken OE, Bisdas T, Haverich A, Mischke R. Ovine blood: Establishment of a list of reference values relevant for blood coagulation in sheep. ASAIO Journal. 2012; 58(1): 79–82. DOI: 10.1097/MAT.0b013e31823a5414.12. Naeemipour M, Hashemitabar GR, Dastjerdi K, Mojaver MJ, Mohammadi HR. Comparison of Fecal Egg Counts and ELISA for the diagnosis of Dicrocoelium Dendriticum infection. Pol J Vet Sci. 2016; 19(3): 573–580. DOI: 10.1515/pjvs-2016-0072.13. Roepstorff A & Nansen P. Epidemiology, diagnosis and control of helminth parasites of swine. Rome: FAO Animal Health Manual; 1998. 14. Torre-Escudero ER, Manzano-Román M, Siles-Lucas R, Pérez-Sánchez JC, Moyano I, Barrera AO. Molecular and functional characterization of a Schistosoma bovis annexin: fibrinolytic and anticoagulant activity. Vet Parasitol. 2012, 184: 25–36. DOI: 10.1016/j.vetpar.2011.08.013.15. Bernal D, Trelis M, Montaner S, Cantalapiedra F, Galiano A, Hackenberg M. Surface analysis of Dicrocoelium dendriticum: The molecular characterization of exosomes reveals the presence of miRNAs. J Proteomics. 2014; 105: 232–241. DOI: 10.1016/j.jprot.2014.02.012.16. Mammen EF. Coagulation defects in liver disease. Med Clin North Am. 1994; 78(3): 545–554. DOI: 10.1016/S0025-7125(16)30146-8.17. Amitrano L, Guardascione MA, Brancaccio V, Balzano A. Coagulation disorders in liver disease. Semin. Liver Dis. 2002; 22(1): 83–96. DOI: 10.1055/s-2002-23205.18. Caldwell SH, Hoffman M, Lisman T, Macik BG, Northup PG, Reddy KR. Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management. Hepatol. 2006; 44(4): 1039–1046. DOI: 10.1002/hep.21303.19. Theodoridis Y, Duncan JL, Maclean JM, Himonas CA. Pathophysiological studies on Dicrocoelium dendriticum infection in sheep. Vet Parasitol. 1991; 39: 61–66. DOI:10.1016/0304-4017(91)90062-Z20. Rojo-Vázquez FA, Meana A, Valcárcel F, Martínez-Valladares M. Update on trematode infections in sheep. Vet Parasitol. 2012; 189(1): 15–38. DOI: 10.1016/j.vetpar.2012.03.029.21. Abdouslam OE, Al-ızzi SA, Al-bassam LS, Azwai SM. Effect of anthelmintic treatment on haematological and coagulation parameters in Ilamas (Lama glama) Infected with gastrointestinal parasites. J Camel Pract Res. 2003; 10(2):149–152.22. Schetters TP, Kleuskens JAGM, Crommert VJ, Leeuw PWJ, Finizio AL, Gorenflot A. Systemic inflammatory responses in dogs experimentally infected with Babesia canis; a haematological study. Vet Parasitol. 2009; 162(1): 7–15. DOI: 10.1016/j.vetpar.2009.02.012.23. Boehm TK, Sojar H, De Nardin E. Concentration-dependent effect of fibrinogen on IgG-specific antigen binding and phagocytosis. Cellular Immuno. 2010; 263: 41–48. DOI: 10.1016/j.cellimm.2010.02.014.24. Rafaj BR, Kuleš J, Selanec J, Vrkić N, Zovko V, Zupančič M. Markers of coagulation activation, endothelial stimulation, and inflammation in dogs with babesiosis. J Vet Intern Med. 2013; 27(5): 1172–1178. DOI: 10.1111/jvim.12146.25. Esmon CT, Xu J, Lupu F. Innate immunity and coagulation. J Thromb Haemost. 2011; 9(1): 182–188. DOI: 10.1111/j.1538-7836.2011.04323.x.26. Gånheim C, Hulten C, Carlsson U, Kindahl H, Niskanen R, Waller KP. The acute phase response in calves experimentally infected with bovine viral diarrhoea virus and/or Mannheimia haemolytica. Zoonoses Public Health. 2003; 50(4): 183–190. DOI: 10.1046/j.1439-0450.2003.00658.x.27. Van Der Ree AM, Mutapi F. The helminth parasite proteome at the host–parasite interface–Informing diagnosis and control. Exp Parasitol. 2015; 157: 48–58. DOI: 10.1016/j.exppara.2015.06.007.28. Knox MR, Besier RB, Le Jambre LF, Kaplan RM, Torres-Acosta JFJ, Miller J. Novel approaches for the control of helminth parasites of livestock VI: Summary of discussions and conclusions. Vet Parasitol. 2012; 186(1): 143–149. DOI: 10.1016/j.vetpar.2011.11.054.29. Colditz IG. Effects of the immune system on metabolism: implications for production and disease resistance in livestock. Livest Sci. 2002; 75(3): 257–268. DOI: 10.1016/S0301-6226(01)00320-7.30. Beck MA, Goater CP, Colwell DD. Comparative recruitment, morphology and reproduction of a generalist trematode, Dicrocoelium dendriticum, in three species of host. Parasitology. 2015; 142(10): 1297–1305. DOI:10.1017/S0031182015000621.31. Joachim A, Ali S, Daugschies A. Fasciola hepatica alters coagulation parameters in sheep plasma in vivo and in vitro. Parasitol Res. 2002; 89(1): 53–58. DOI: 10.1007/s00436-002-0723-3.32. Matula SJM, Plasenzotti R, Spiel A, Quehenberger P, Jilma B. Interspecies differences in coagulation profile. Thromb Haemost. 2008; 100(03): 397–404. 33. Gardiner C, Adcock DM, Carrington LR, Kottke MK, Marlar RA, McGlasson DL. Protocol for the Evaluation, Validation, and Implementation of Coagulometers; Approved Guideline H57-A. Clinical and Laboratory Standards Institute. 2008.34. Schulman S, Elbazi R, Zondag M, O'Donnell M. Clinical factors influencing normalization of prothrombin time after stopping warfarin: a retrospective cohort study. Thromb J. 2008; 6(1): 15. DOI: 10.1186/1477-9560-6-15.

Details

Primary Language English
Subjects Health Care Sciences and Services
Journal Section Research Articles
Authors

Hasan ERDOĞAN
AYDIN ADNAN MENDERES ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, KLİNİK BİLİMLER BÖLÜMÜ, VETERİNERLİK İÇ HASTALIKLARI ANABİLİM DALI
0000-0001-5141-5108
Türkiye


Mehmet GÜLTEKİN This is me
AYDIN ADNAN MENDERES ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, KLİNİK BİLİMLER BÖLÜMÜ, VETERİNERLİK İÇ HASTALIKLARI ANABİLİM DALI
0000-0002-5197-2403
Türkiye


Kerem URAL
ADNAN MENDERES ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, KLİNİK BİLİMLER BÖLÜMÜ, VETERİNERLİK İÇ HASTALIKLARI ANABİLİM DALI
0000-0003-1867-7143
Türkiye


Yasin PARLATIR
KIRIKKALE ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, HASTALIKLAR VE KLİNİK BİLİMLERİ BÖLÜMÜ, VETERİNERLİK İÇ HASTALIKLARI ANABİLİM DALI
0000-0002-6210-8979
Türkiye


Adnan AYAN This is me
VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, ZOOTEKNİ VE HAYVAN BESLEME BÖLÜMÜ, VETERİNERLİK GENETİĞİ ANABİLİM DALI
0000-0002-6564-3416


Songul ERDOĞAN
AYDIN ADNAN MENDERES ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, KLİNİK BİLİMLER BÖLÜMÜ, VETERİNERLİK İÇ HASTALIKLARI ANABİLİM DALI
0000-0002-7833-5519


Serdar PAŞA
AYDIN ADNAN MENDERES ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, KLİNİK BİLİMLER BÖLÜMÜ, VETERİNERLİK İÇ HASTALIKLARI ANABİLİM DALI
0000-0003-4957-9263

Publication Date June 30, 2019
Application Date February 6, 2019
Acceptance Date June 19, 2019
Published in Issue Year 2019, Volume 4, Issue 1

Cite

APA Erdoğan, H. , Gültekin, M. , Ural, K. , Parlatır, Y. , Ayan, A. , Erdoğan, S. & Paşa, S. (2019). Evaluation of albendazole treatment on coagulation profile in sheep naturally infected with Dicrocoelium dentriticum . Veterinary Journal of Mehmet Akif Ersoy University , 4 (1) , 8-13 . DOI: 10.24880/maeuvfd.523108