Investigation of antiproliferative effects of Hypericum perforatum oil on myeloma cells

Year 2020, Volume: 5 Issue: 2, 79 - 82, 31.08.2020

Soner Tutun Muhammet Mükerrem Kaya Melike Sultan Usluer Hidayet Tutun

https://doi.org/10.24880/maeuvfd.728975

Cited By: 1

Abstract

St. Johns wort (Hypericum perforatum) is a medicinal plant that exhibits important biological activities exhibit important biological activities being antioxidant, anti-inflammatory, immunomodulatory and/or antitumour. The aim of this study was to investigate antiproliferative effect of H. perforatum oil purchased from a commercial vendor on mouse myeloma cells. The cells were treated with various concentration (10%, 5%, 2%, 1%, 0.5%, 0.25%, 0.2% and 0.1%) of dimethyl sulfoxide (DMSO) to determine the non-toxic concentration. The cells were treated with various concentrations (15.6-500 ppm) of the oil dissolved in DMSO to examine its antiproliferative activity. Non-toxic dose of DMSO was at the concentration of lower than 0.2%. No effect on the cell proliferation was observed in the applied concentration of the oil. In conclusion, the oil had no antiproliferative effect on Myeloma cells at these concentrations.

Keywords

Antiproliferative activity, Hypericum perforatum, Myeloma cells

References

• Hideshima T, Mitsiades C, Tonon G, Richardson PG, Anderson KC. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat Rev Cancer. 2007;7(8):585-98.
• Wang J, Hendrix A, Hernot S, Lemaire M, De Bruyne E, Valckenborgh EV, et al. Bone marrow stromal cell–derived exosomes as communicators in drug resistance in multiple myeloma cells. Blood. 2014;124(4):555-66.
• Ríos-Tamayo R, Rodríguez DS, Chang-Chan YL, Pérez MJS. Epidemiology of Multiple Myeloma. In Update on Multiple Myeloma. IntechOpen. (2018).
• Raab MS, Podar K, Breitkreutz I, Richardson PG, Anderson KC Multiple myeloma. Lancet. 2009;374:324-39.
• World Health Organization. https://www.who.int/news-room/fact-sheets/detail/cancer 2018. Erişim tarihi:20.02.2020.
• National Cancer Institute (NCI). Cancer Stat Facts: Myeloma. https:/./seer.cancer.gov/statfacts/html/mulmy.html. Erişim tarihi:20.02.2020.
• Ludwig H, Miguel JS, Dimopoulos MA, Palumbo A, Sanz RG, Powles R, et al. International Myeloma Working Group recommendations for global myeloma care. Leukemia. 2014;28;981-92.
• Gottschling S, Meyer S, Längler A, Scharifi G, Ebinger F, Gronwald B. Differences in use of complementary and alternative medicine between children and adolescents with cancer in Germany: a population based survey. Pediatr Blood Cancer. 2014; 61:488–92.
• National Cancer Institute (NCI), (2018). Definition of Complementary and Alternative Medicine CAM according to the National Center for Complementary and Integrative Health. https://nccih.nih.gov/health/integrative-health. Erişim tarihi: 24. 02. 2020.
• Tabish SA. Complementary and alternative healthcare: is it evidence-based? International journal of health sciences. 2008;2(1):V-IX.
• Keene MR, Heslop IM, Sabesan SS, Glass BD. Complementary and alternative medicine use in cancer: a systematic review. complementary therapies in clinical practice. 2019;35:33-47.
• Baytop T. Therapy with Herbs in Turkey, Publication No. 3255. Istanbul Univ. Press, Istanbul, 1984 pp. 185-6.
• Barnes J, Anderson LA, Phillipson JD. St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties. J Pharm Pharmacol. 2001;53(5):583-600.
• Weber ND, Murray BK, North JA, Wood SG. The antiviral agent hypericin has in vitro activity against HSV-1 through non-specific association with viral and cellular membranes. Antivir. Chem. Chemother. 1994;5:83-90.
• Nezhad SK, Zenouz AT, Aghazadeh M, Kafil HS. Strong antimicrobial activity of Hypericum perforatum L. against oral isolates of Lactobacillus spp. Cell. Mol. Biol.(Noisy-le-grand). 2017;63:58-62.
• Fiebich B, Heinrich M, Langosch JM, Kammerer N, Lieb K. Antibacterial activity of hyperforin from St John’s wort. Lancet. 1999;354:777.
• Savikin K, Dobrić S, Tadić V, Zdunić G. Antiinflammatory activity of ethanol extracts of Hypericum perforatum L., H. barbatum Jacq., H. hirsutum L., H. richeri Vill. and H. androsaemum L. in rats. Phytother Res: PTR. 2007;21(2):176-180.
• Zdunić G, Gođevac D, Milenković M, Vučićević D, Šavikin K, Menković N, et al. Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats. Phytother Res. 2009;23(11):1559-64.
• Angiolella L, Carradori S, Maccallini C, Giusiano G, T Supuran C. Targeting Malassezia species for novel synthetic and natural antidandruff agents. Curr. Med. Chem. 2017;24(22):2392-412.
• Alp H, Tutun H, Kaplan HM, Şingirik E, Altıntaş L. Investigation of apoptotic effects of Hypericum perforatum extract on breast cancer cell line. Harran Üniv Vet Fak Derg. 2019;8(2):198-202.
• Yadollah-Damavandi S, Chavoshi-Nejad M, Jangholi E, Nekouyian N, Hosseini S, Seifaee A, et al. Topical Hypericum perforatum improves tissue regeneration in full-thickness excisional wounds in diabetic rat model. Evid-Based Complementary Altern. Med. 2015;245-328.
• Surmuş Asan H. The Studies on The endemic Hypericum Species from Turkey, Batman univ. yaşam bilim. derg. 2019;9(2):253-68.
• Dolezal AG, St Clair AL, Zhang G, Toth AL, O’Neal ME. Native habitat mitigates feast-famine conditions faces by honey bees in an agricultural landscape. PNAS. 2019;116(50):25147-155.
• Schempp CM, Kirkin V, Simon-Haarhaus B, Kersten A, Kiss J, Termeer CC, et al. Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis. Oncogene. 2002;21(8):1242-50.
• Cenić-Milošević D, Tambur Z, Ivančajić S, Stanojković T, Grozdanić N, Kulišić Z, et al. Antiproliferative effects of Tanaceti partheni, Hypericum perforatum and propolis on HeLa cells. Arch. Biol. Sci. 2014;66(2):705-12.
• Mosmann T. Rapid colorimetric assay for cellular growth and survival application to proliferation and cytotoxicity assays. J. Immunol. Methods. 1983;65:55-63.
• Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, MacIntyre MF, et al. The global burden of cancer 2013. JAMA oncology. 2015;1(4):505-27.
• LeBaron S, Zeltzer L. Behavioral intervention for reducing chemotherapy-related nausea and vomiting in adolescents with cancer. J Adolesc Health. 1984;5(3):178-82.
• Morrow GR. The effect of a susceptibility to motion sickness on the side effects of cancer chemotherapy. Cancer. 1985;55(12):2766-70.
• Qin SY, Cheng YJ, Lei Q, Zhang AQ, Zhang XZ. Combinational strategy for high-performance cancer chemotherapy. Biomaterials. 2018;171:178-97.
• Laakmann G, Jahn G, Schüle C. Hypericum perforatum extract in treatment of mild to moderate depression. Clinical and pharmacological aspects. Nervenarzt. 2002;73(7):600-12.
• Cayci MK, Dayioglu H. Hypericum perforatum extracts healed gastric lesions induced by hypothermic restraint stress in Wistar rats. Saudi Med J. 2009;30(6):750-4.
• Süntar IP, Akkol EK, Yılmazer D, Baykal T, Kırmızıbekmez H, Alper M, et al. Investigations on the in vivo wound healing potential of Hypericum perforatum L. J Ethnopharmacol. 2010;127(2):468-77.
• Reichling J, Weseler A, Saller R. A current review of the antimicrobial activity of Hypericum perforatum L. Pharmacopsychiatry. 2001;34(Sup. 1):116-8.
• Altıparmak M, Eskitaşçıoğlu T. Comparison of systemic and topical Hypericum perforatum on diabetic surgical wounds. J Invest Surg. 2018;31(1):29-37.
• Selek S, Esrefoglu M, Meral I, Bulut H, Caglar HG, Sonuc G, et al. Effects of Oenothera biennis L. and Hypericum perforatum L. extracts on some central nervous system myelin proteins, brain histopathology and oxidative stress in mice with experimental autoimmune encephalomyelitis. Biotech Histochem. 2019;94(2):75-83.
• Yechiam E, Ben-Eliezer D, Ashby NJ, Bar-Shaked M. The acute effect of Hypericum perforatum on short-term memory in healthy adults. Psychopharmacology. 2019;236(2):613-23.
• Quassinti L, Lupidi G, Maggi F, Sagratini G, Papa F, Vittori S, et al. Antioxidant and antiproliferative activity of Hypericum hircinum L. subsp. majus (Aiton) N. Robson essential oil. Nat Prod Res. 2013;27(10):862-8.
• Roscetti G, Franzese O, Comandini A, Bonmassar E. Cytotoxic activity of Hypericum perforatum L. on K562 erythroleukemic cells: differential effects between methanolic extract and hypericin. Phytother Res. 2004;18(1):66-72.