Research Article
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The acute effect of thiamine on serum insulin levels and some biochemical parameters in excessive alcohol-consuming rats

Year 2022, Volume 7, Issue 2, 120 - 125, 31.08.2022
https://doi.org/10.24880/maeuvfd.1100674

Abstract

There are studies that present metabolic disorders in alcohol drinkers are associated with thiamine deficiency. Therefore, in the present study, it was aimed to investigate the effectiveness of thiamine in rats with binge drinking model. For this purpose, total 21 spraque dawley rats were divided into three equal groups as control, alcohol and thiamine+alcohol groups. The thiamine+ethanol group was given thiamine at a daily dose of 100 mg/kg by oral gavage, starting 2 days before the ethanol administration. Alcohol and thiamine+alcohol groups were given 3.45g/kg/day ethanol as 20%. At the end of the study, while serum total bile acid, total bilirubin and insulin levels increased in rats in the alcohol group compared to the rats in the control group; total protein and albumin levels decreased (P<0.05). In the thiamine + alcohol group, LDL-cholesterol, total cholesterol, bile acid levels and AST enzyme activity increased, while ALT enzyme activity and total protein levels decreased compared to the control group (P<0.05). There was no statistically significant result in the values in the thiamine+alcohol group compared to the alcohol group. It has been concluded that acutely administered thiamine supplementation had no effect on alcohol-induced biochemical parameter changes in binge-drinking animals. In this sense, studies with longer-term thiamine use are needed.

References

  • Al-Attas, O., Al-Daghri, N., Alokail, M., Abd-Alrahman, S., Vinodson, B., Sabico, S. (2014). Metabolic Benefits of Six-month Thiamine Supplementation in Patients With and Without Diabetes Mellitus Type 2. Clinical medicine insights. Endocrinology and diabetes, 7, 1–6. https://doi.org/10.4137/CMED.S13573
  • Avogaro A., Valerio A., Miola M., Crepaldi C., Pavan P., Tiengo A., del Prato S. (1996). Ethanol impairs insulin-mediated glucose uptake by an indirect mechanism. The Journal of clinical endocrinology and metabolism, 81(6), 2285–2290. https://doi.org/10.1210/jcem.81.6.8964865
  • Bajac, H., Feliu-Soler, A., Meerhoff, D., Latorre, L., Elices, M. (2016). Iudicium: An Educational Intervention for addressing Risk Perception of Alcohol Abuse in Adolescents. Adicciones, 28(1), 41–47. https://doi.org/10.20882/adicciones.789
  • Bettendorff, L., Mastrogiacomo, F., Kish, S. J., Grisar, T. (1996). Thiamine, thiamine phosphates, and their metabolizing enzymes in human brain. Journal of neurochemistry, 66(1), 250–258. https://doi.org/10.1046/j.1471-4159.1996.66010250.x
  • Bouayed, J., Bohn, T. (2010). Exogenous antioxidants--Double-edged swords in cellular redox state: Health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxidative medicine and cellular longevity, 3(4), 228–237. https://doi.org/10.4161/oxim.3.4.12858
  • Chandrakumar, A., Bhardwaj, A., 't Jong, G. W. (2018). Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis. Journal of basic and clinical physiology and pharmacology, 30(2), 153–162. https://doi.org/10.1515/jbcpp-2018-0075
  • Dhillon, A.S., Xu, D., Palmer, T.N. (1996). Acute ethanol-mediated insulin resistance in the rat: The role of ethanol oxidation. Addiction biology, 1(4), 427–435. https://doi.org/10.1080/1355621961000125036
  • Donepudi, A. C., Ferrell, J. M., Boehme, S., Choi, H. S., Chiang, J. (2017). Deficiency of cholesterol 7α-hydroxylase in bile acid synthesis exacerbates alcohol-induced liver injury in mice. Hepatology communications, 2(1), 99–112. https://doi.org/10.1002/hep4.1129
  • Jang, J. E., Eun H. K. (2012). The impacts of alcohol consumption on glucose metabolism. The Journal of Korean Diabetes 13 (2), 81-84. https://doi.org/10.4093/jkd.2012.13.2.81
  • Lemos, C., Azevedo, I., Martel, F. (2005). Effect of red wine on the intestinal absorption of thiamine and folate in the rat: comparison with the effect of ethanol alone. Alcoholism, clinical and experimental research, 29(4), 664–671. https://doi.org/10.1097/01.alc.0000159114.86360.b5
  • Lieber, C.S. (1997). Ethanol metabolism, cirrhosis and alcoholism. Clinica chimica acta; international journal of clinical chemistry, 257(1), 59–84. https://doi.org/10.1016/s0009-8981(96)06434-0
  • Lukienko, P. I., Mel'nichenko, N. G., Zverinskii, I. V., & Zabrodskaya, S. V. (2000). Antioxidant properties of thiamine. Bulletin of experimental biology and medicine, 130(9), 874–876. https://doi.org/10.1007/BF02682257
  • Dguzeh, U., Haddad, N. C., Smith, K., Johnson, J. O., Doye, A. A., Gwathmey, J. K., Haddad, G. E. (2018). Alcoholism: A Multi-Systemic Cellular Insult to Organs. International journal of environmental research and public health, 15(6), 1083. https://doi.org/10.3390/ijerph15061083.
  • Gastaldi, G., Casirola, D., Ferrari, G., Rindi, G. (1989). Effect of chronic ethanol administration on thiamine transport in microvillous vesicles of rat small intestine. Alcohol and alcoholism, 24(2), 83–89. https://doi.org/10.1093/oxfordjournals.alcalc.a044888.
  • Harinasuta, U., Chomet, B., Ishak, K. and Zimmerman, H.J. (1967). Steatonecrosis-Mallory body type. Medicine, 46, 141-162. https://doi.org/10.1097/00005792-196703000-00008.
  • Langlais, P. J. (1995). Alcohol-Related Thiamine Deficiency: Impact on Cognitive and Memory Functioning. Alcohol health and research world, 19(2), 113–121. https://doi.org/10.1097/00005792-196703000-00008.
  • Liu, G., Zhang, Y., Liu, C., Xu, D., Zhang, R., Cheng, Y., Pan, Y., Huang, C., Chen, Y. (2014). Luteolin alleviates alcoholic liver disease induced by chronic and binge ethanol feeding in mice. The Journal of nutrition, 144(7), 1009–1015. https://doi.org/10.3945/jn.114.193128
  • Maltoff, D.S., Selinger, M.J. and Kaplan, M.M. (1980) Hepatic transaminase activity in alocholic liver disease. Gastroenterology, 78, 1389-1392. https://doi.org/10.1016/S0016-5085(19)30490-1
  • Manley, S. and Ding, W. (2015). Role of farnesoid X receptor and bile acids in alcoholic liver disease, Acta Pharmaceutica Sinica B, 5 (2), 158-167. https://doi.org/10.1016/j.apsb.2014.12.011
  • Naimi, T.S., Brewer, R.D., Mokdad, A., Denny, C., Serdula, M.K. and Marks, J.S. (2003). Binge Drinking among US Adults. JAMA., 289 (1), 70-75. https://doi.org/10.1001/jama.289.1.70
  • Ngandeu, N., Mbanya, A., Lontchi-Yimagou, E., Kamwa, V., Nguewa, J.-L, Katte, J., Omengue, A., Choukem, S.P, Dehayem, M., Mbanya, J.C., Sobngwi, E. (2018). Effect of Binge Drinking on Glucose Metabolism in Occasional Drinkers: An Experimental Study. Open Journal of Endocrine and Metabolic Diseases., 08, 49-58. 10.4236/ojemd.2018.81006
  • Nygren, K., Hammarström, A., Rolandsson, O. (2017). Binge drinking and total alcohol consumption from 16 to 43 years of age are associated with elevated fasting plasma glucose in women: results from the northern Swedish cohort study. BMC public health., 17(1), 509. https://doi.org/10.1186/s12889-017-4437-y
  • O'Keefe, J. H., Bhatti, S. K., Bajwa, A., DiNicolantonio, J. J., Lavie, C. J. (2014). Alcohol and cardiovascular health: the dose makes the poison…or the remedy. Mayo Clinic proceedings, 89(3), 382–393. https://doi.org/10.1016/j.mayocp.2013.11.005
  • O'Malley, S. S., Gueorguieva, R., Wu, R., & Jatlow, P. I. (2015). Acute alcohol consumption elevates serum bilirubin: an endogenous antioxidant. Drug and alcohol dependence, 149, 87–92. doi: 10.1016/j.drugalcdep.2015.01.023
  • Portari, G.V. , Vannucchi, H., Jordao Jr., A.A. (2013). Liver, plasma and erythrocyte levels of thiamine and its phosphate esters in rats with acute ethanol intoxication: a comparison of thiamine and benfotiamine administration. Eur. J. Pharm. Sci., 48 (4–5), 799-802. https://doi.org/10.1016/j.ejps.2013.01.010
  • Portari, G. V., Ovidio, P. P., Deminice, R., Jordão, A. A. (2016). Protective effect of treatment with thiamine or benfotiamine on liver oxidative damage in rat model of acute ethanol intoxication. Life sciences, 162, 21–24. https://doi.org/10.1016/j.lfs.2016.08.017
  • Ward, R.J., Jutla, J., Peters, T. (1989). Antioxidant status in alcoholic liver disease. Adv. Biosci.,76, 343-351 28. Schrieks, I.C., Heil, A.L., Hendriks, H.F., Mukamal, K.J., Beulens, J.W. (2015). The effect of alcohol consumption on insulin sensitivity and glycemic status: A systematic review and meta-analysis of intervention studies. Diabetes Care, 38, 723–732. https://doi.org/10.2337/dc14-1556
  • Shanmugam, K. R., Mallikarjuna, K., Reddy, K. S. (2011) Effect of alcohol on blood glucose and antioxidant enzymes in the liver and kidney of diabetic rats. Indian journal of pharmacology, 43(3), 330–335. doi:10.4103/0253-7613.81504.
  • Shapiro, H., Kolodziejczyk, A. A., Halstuch, D., & Elinav, E. (2018). Bile acids in glucose metabolism in health and disease. The Journal of experimental medicine, 215(2), 383–396. https://doi.org/10.1084/jem.20171965
  • Spolarics, Z., Bagby, G.J., Pekala, P.H., Dobrescu, C., Skrepnik, N., Spitzer J.J. (1994). Acute alcohol administration attenuates insulin-mediated glucose use by skeletal muscle. The American journal of physiology, 267(6 Pt 1), E886–E891. https://doi.org/10.1152/ajpendo.1994.267.6.E886
  • Steiner, J. L., Crowell, K. T., & Lang, C. H. (2015). Impact of Alcohol on Glycemic Control and Insulin Action. Biomolecules, 5(4), 2223–2246. https://doi.org/10.3390/biom5042223.
  • Syring, K. E., Cyphert, T. J., Beck, T. C., Flynn, C. R., Mignemi, N. A., & McGuinness, O. P. (2019). Systemic bile acids induce insulin resistance in a TGR5-independent manner. American Journal of Physiology-Endocrinology and Metabolism, 316(5), E782-E793. https://doi.org/10.1152/ajpendo.00362.2018
  • Tallaksen, C.M., Sande, A., Bohmer, T., Bell, H., Karlsen, J. (1993). Kinetics of thiamin and thiamin phosphate esters in human blood, plasma and urine after 50 mg intravenously or orally. European journal of clinical pharmacology , 44 (1) , 73-78. https://doi.org/10.1007/BF00315284
  • Wechsler, H., Davenport, A., Dowdall, G., Moeykens, B., Castillo, S. (1994). Health and behavioral consequences of binge drinking in college. A national survey of students at 140 campuses. JAMA., 272(21), 1672-1677. doi:10.1001/jama.1994.03520210056032
  • Wood, D., De Backer, G., Faergeman, O., Graham, I., Mancia, G., Pyörälä, K. (1998). Prevention of coronary heart disease in clinical practice: recommendations of the Second Joint Task Force of European and other Societies on Coronary Prevention. Atherosclerosis,140(2), 199-270. doi: 10.1016/s0021-9150(98)90209-x.

Year 2022, Volume 7, Issue 2, 120 - 125, 31.08.2022
https://doi.org/10.24880/maeuvfd.1100674

Abstract

References

  • Al-Attas, O., Al-Daghri, N., Alokail, M., Abd-Alrahman, S., Vinodson, B., Sabico, S. (2014). Metabolic Benefits of Six-month Thiamine Supplementation in Patients With and Without Diabetes Mellitus Type 2. Clinical medicine insights. Endocrinology and diabetes, 7, 1–6. https://doi.org/10.4137/CMED.S13573
  • Avogaro A., Valerio A., Miola M., Crepaldi C., Pavan P., Tiengo A., del Prato S. (1996). Ethanol impairs insulin-mediated glucose uptake by an indirect mechanism. The Journal of clinical endocrinology and metabolism, 81(6), 2285–2290. https://doi.org/10.1210/jcem.81.6.8964865
  • Bajac, H., Feliu-Soler, A., Meerhoff, D., Latorre, L., Elices, M. (2016). Iudicium: An Educational Intervention for addressing Risk Perception of Alcohol Abuse in Adolescents. Adicciones, 28(1), 41–47. https://doi.org/10.20882/adicciones.789
  • Bettendorff, L., Mastrogiacomo, F., Kish, S. J., Grisar, T. (1996). Thiamine, thiamine phosphates, and their metabolizing enzymes in human brain. Journal of neurochemistry, 66(1), 250–258. https://doi.org/10.1046/j.1471-4159.1996.66010250.x
  • Bouayed, J., Bohn, T. (2010). Exogenous antioxidants--Double-edged swords in cellular redox state: Health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxidative medicine and cellular longevity, 3(4), 228–237. https://doi.org/10.4161/oxim.3.4.12858
  • Chandrakumar, A., Bhardwaj, A., 't Jong, G. W. (2018). Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis. Journal of basic and clinical physiology and pharmacology, 30(2), 153–162. https://doi.org/10.1515/jbcpp-2018-0075
  • Dhillon, A.S., Xu, D., Palmer, T.N. (1996). Acute ethanol-mediated insulin resistance in the rat: The role of ethanol oxidation. Addiction biology, 1(4), 427–435. https://doi.org/10.1080/1355621961000125036
  • Donepudi, A. C., Ferrell, J. M., Boehme, S., Choi, H. S., Chiang, J. (2017). Deficiency of cholesterol 7α-hydroxylase in bile acid synthesis exacerbates alcohol-induced liver injury in mice. Hepatology communications, 2(1), 99–112. https://doi.org/10.1002/hep4.1129
  • Jang, J. E., Eun H. K. (2012). The impacts of alcohol consumption on glucose metabolism. The Journal of Korean Diabetes 13 (2), 81-84. https://doi.org/10.4093/jkd.2012.13.2.81
  • Lemos, C., Azevedo, I., Martel, F. (2005). Effect of red wine on the intestinal absorption of thiamine and folate in the rat: comparison with the effect of ethanol alone. Alcoholism, clinical and experimental research, 29(4), 664–671. https://doi.org/10.1097/01.alc.0000159114.86360.b5
  • Lieber, C.S. (1997). Ethanol metabolism, cirrhosis and alcoholism. Clinica chimica acta; international journal of clinical chemistry, 257(1), 59–84. https://doi.org/10.1016/s0009-8981(96)06434-0
  • Lukienko, P. I., Mel'nichenko, N. G., Zverinskii, I. V., & Zabrodskaya, S. V. (2000). Antioxidant properties of thiamine. Bulletin of experimental biology and medicine, 130(9), 874–876. https://doi.org/10.1007/BF02682257
  • Dguzeh, U., Haddad, N. C., Smith, K., Johnson, J. O., Doye, A. A., Gwathmey, J. K., Haddad, G. E. (2018). Alcoholism: A Multi-Systemic Cellular Insult to Organs. International journal of environmental research and public health, 15(6), 1083. https://doi.org/10.3390/ijerph15061083.
  • Gastaldi, G., Casirola, D., Ferrari, G., Rindi, G. (1989). Effect of chronic ethanol administration on thiamine transport in microvillous vesicles of rat small intestine. Alcohol and alcoholism, 24(2), 83–89. https://doi.org/10.1093/oxfordjournals.alcalc.a044888.
  • Harinasuta, U., Chomet, B., Ishak, K. and Zimmerman, H.J. (1967). Steatonecrosis-Mallory body type. Medicine, 46, 141-162. https://doi.org/10.1097/00005792-196703000-00008.
  • Langlais, P. J. (1995). Alcohol-Related Thiamine Deficiency: Impact on Cognitive and Memory Functioning. Alcohol health and research world, 19(2), 113–121. https://doi.org/10.1097/00005792-196703000-00008.
  • Liu, G., Zhang, Y., Liu, C., Xu, D., Zhang, R., Cheng, Y., Pan, Y., Huang, C., Chen, Y. (2014). Luteolin alleviates alcoholic liver disease induced by chronic and binge ethanol feeding in mice. The Journal of nutrition, 144(7), 1009–1015. https://doi.org/10.3945/jn.114.193128
  • Maltoff, D.S., Selinger, M.J. and Kaplan, M.M. (1980) Hepatic transaminase activity in alocholic liver disease. Gastroenterology, 78, 1389-1392. https://doi.org/10.1016/S0016-5085(19)30490-1
  • Manley, S. and Ding, W. (2015). Role of farnesoid X receptor and bile acids in alcoholic liver disease, Acta Pharmaceutica Sinica B, 5 (2), 158-167. https://doi.org/10.1016/j.apsb.2014.12.011
  • Naimi, T.S., Brewer, R.D., Mokdad, A., Denny, C., Serdula, M.K. and Marks, J.S. (2003). Binge Drinking among US Adults. JAMA., 289 (1), 70-75. https://doi.org/10.1001/jama.289.1.70
  • Ngandeu, N., Mbanya, A., Lontchi-Yimagou, E., Kamwa, V., Nguewa, J.-L, Katte, J., Omengue, A., Choukem, S.P, Dehayem, M., Mbanya, J.C., Sobngwi, E. (2018). Effect of Binge Drinking on Glucose Metabolism in Occasional Drinkers: An Experimental Study. Open Journal of Endocrine and Metabolic Diseases., 08, 49-58. 10.4236/ojemd.2018.81006
  • Nygren, K., Hammarström, A., Rolandsson, O. (2017). Binge drinking and total alcohol consumption from 16 to 43 years of age are associated with elevated fasting plasma glucose in women: results from the northern Swedish cohort study. BMC public health., 17(1), 509. https://doi.org/10.1186/s12889-017-4437-y
  • O'Keefe, J. H., Bhatti, S. K., Bajwa, A., DiNicolantonio, J. J., Lavie, C. J. (2014). Alcohol and cardiovascular health: the dose makes the poison…or the remedy. Mayo Clinic proceedings, 89(3), 382–393. https://doi.org/10.1016/j.mayocp.2013.11.005
  • O'Malley, S. S., Gueorguieva, R., Wu, R., & Jatlow, P. I. (2015). Acute alcohol consumption elevates serum bilirubin: an endogenous antioxidant. Drug and alcohol dependence, 149, 87–92. doi: 10.1016/j.drugalcdep.2015.01.023
  • Portari, G.V. , Vannucchi, H., Jordao Jr., A.A. (2013). Liver, plasma and erythrocyte levels of thiamine and its phosphate esters in rats with acute ethanol intoxication: a comparison of thiamine and benfotiamine administration. Eur. J. Pharm. Sci., 48 (4–5), 799-802. https://doi.org/10.1016/j.ejps.2013.01.010
  • Portari, G. V., Ovidio, P. P., Deminice, R., Jordão, A. A. (2016). Protective effect of treatment with thiamine or benfotiamine on liver oxidative damage in rat model of acute ethanol intoxication. Life sciences, 162, 21–24. https://doi.org/10.1016/j.lfs.2016.08.017
  • Ward, R.J., Jutla, J., Peters, T. (1989). Antioxidant status in alcoholic liver disease. Adv. Biosci.,76, 343-351 28. Schrieks, I.C., Heil, A.L., Hendriks, H.F., Mukamal, K.J., Beulens, J.W. (2015). The effect of alcohol consumption on insulin sensitivity and glycemic status: A systematic review and meta-analysis of intervention studies. Diabetes Care, 38, 723–732. https://doi.org/10.2337/dc14-1556
  • Shanmugam, K. R., Mallikarjuna, K., Reddy, K. S. (2011) Effect of alcohol on blood glucose and antioxidant enzymes in the liver and kidney of diabetic rats. Indian journal of pharmacology, 43(3), 330–335. doi:10.4103/0253-7613.81504.
  • Shapiro, H., Kolodziejczyk, A. A., Halstuch, D., & Elinav, E. (2018). Bile acids in glucose metabolism in health and disease. The Journal of experimental medicine, 215(2), 383–396. https://doi.org/10.1084/jem.20171965
  • Spolarics, Z., Bagby, G.J., Pekala, P.H., Dobrescu, C., Skrepnik, N., Spitzer J.J. (1994). Acute alcohol administration attenuates insulin-mediated glucose use by skeletal muscle. The American journal of physiology, 267(6 Pt 1), E886–E891. https://doi.org/10.1152/ajpendo.1994.267.6.E886
  • Steiner, J. L., Crowell, K. T., & Lang, C. H. (2015). Impact of Alcohol on Glycemic Control and Insulin Action. Biomolecules, 5(4), 2223–2246. https://doi.org/10.3390/biom5042223.
  • Syring, K. E., Cyphert, T. J., Beck, T. C., Flynn, C. R., Mignemi, N. A., & McGuinness, O. P. (2019). Systemic bile acids induce insulin resistance in a TGR5-independent manner. American Journal of Physiology-Endocrinology and Metabolism, 316(5), E782-E793. https://doi.org/10.1152/ajpendo.00362.2018
  • Tallaksen, C.M., Sande, A., Bohmer, T., Bell, H., Karlsen, J. (1993). Kinetics of thiamin and thiamin phosphate esters in human blood, plasma and urine after 50 mg intravenously or orally. European journal of clinical pharmacology , 44 (1) , 73-78. https://doi.org/10.1007/BF00315284
  • Wechsler, H., Davenport, A., Dowdall, G., Moeykens, B., Castillo, S. (1994). Health and behavioral consequences of binge drinking in college. A national survey of students at 140 campuses. JAMA., 272(21), 1672-1677. doi:10.1001/jama.1994.03520210056032
  • Wood, D., De Backer, G., Faergeman, O., Graham, I., Mancia, G., Pyörälä, K. (1998). Prevention of coronary heart disease in clinical practice: recommendations of the Second Joint Task Force of European and other Societies on Coronary Prevention. Atherosclerosis,140(2), 199-270. doi: 10.1016/s0021-9150(98)90209-x.

Details

Primary Language English
Subjects Health Care Sciences and Services
Journal Section Research Articles
Authors

Hale ERGİN EĞRİTAĞ> (Primary Author)
MEHMET AKİF ERSOY ÜNİVERSİTESİ
0000-0003-4240-4698
Türkiye

Supporting Institution -
Project Number -
Thanks The author thanks to Dr. Volkan İPEK for his assistance with the experiment.
Publication Date August 31, 2022
Application Date April 11, 2022
Acceptance Date August 15, 2022
Published in Issue Year 2022, Volume 7, Issue 2

Cite

APA Ergin Eğritağ, H. (2022). The acute effect of thiamine on serum insulin levels and some biochemical parameters in excessive alcohol-consuming rats . Veterinary Journal of Mehmet Akif Ersoy University , 7 (2) , 120-125 . DOI: 10.24880/maeuvfd.1100674