The Paradigm of Autoimmunity: Is Vitamin D the New Player?

Year 2016, Volume: 8 Issue: 2, 1 - 6, 01.08.2016

Gülbüz Sezgin Eşref M. Özer Oya Uygur Bayramiçli Feride Sinem Akgün Fehime Benli Aksungar Selim Nalbant

Abstract

Aim: Vitamin D is necessary for the bone and mineral homeostasis and has also immune regulatory and anti-inflammatory functions. It has been hypothesized that there is a relation between vitamin D deficiency or insufficiency and autoimmune thyroiditis. We aim that to show any relationship between vitamin D deficiency and thyroid autoimmunity. Material and Methods: This prospective study is performed between August 2010 and May 2011 at the Department of Internal Medicine, Endocrinology and Emergency Medicine of Maltepe University, School pof Medicine Hospital. The Ethics Committee of Maltepe University Medical Faculty approved the study.274 patients with Hashimoto’s thyroiditiswere evaluated prospectively for vitamin D, TSH, anti-thyroid peroxidase antibody anti-TPO and anti-thyroglobulin anti-Tg .The correlation between vitamin D and autoimmune parameters is analyzed. Results: According to vitamin D levels there is a statistically significant difference between anti- TPO levels p=0.024; p0.05 . There is also no difference in TSH levels according to vitamin D subgroups p=0.177; p>0.05 . Conclusion: In patients with Hashimoto’s thyroiditis there is a positive correlation between vitamin D level and anti-TPO but not anti-Tg.

Keywords

nazolabiyal, V-Y ilerletme flebi, ortayüz defekti, ektropiyon

Otoimünite Paradigması: D Vitamini Yeni Oyuncu mu?

Abstract

Amaç: Vitamin D, kemik ve mineral homeostazı için gereklidir ve aynı zamanda immunregülatör ve antiinflamatuar fonksiyonları vardır. Vitamin D eksikliği veya yetersizliği ile otoimmün tiroiditler arasında ilişki olduğu hipotezi öne sürülmüştür. Bu çalışmada Vitamin D eksikliği ile tiroid otoimmünitesi arasında ilişki olup olmadığını göstermeyi amaçladık. Materyal- Metod: Çalışmamız Ağustos 2010 ile mayıs 2011 yılları arasında Maltepe Üniversitesi Eğitim ve Araştırma Hastanesi İç Hastalıkları, Endokrinoloji ve Acil servis bölümlerinde prospektif olarak yapılmıştır. Maltepe Üniversitesi Tıp Fakültesi Etik Kurul Komitesinden onay alınmıştır.Hashimoto tiroiditi olan 274 hastada Vitamin D, TSH, anti Tiroid Peroksidaz Antikoru Anti-TPO ve anti Tiroglobulin Anti- Tg seviyeleri ölçülmüştür. Vitamin D ile otoimmün parametreler arasındaki korelasyon incelenmiştir. Bulgular: Vitamin D ile anti-TPO seviyeleri arasında istatistiksel olarak anlamlı bir ilişki vardır p=0.024; p0.05 .D vitamini alt gruplarına gore TSH seviyelerinde de anlamlı bir farklılık yoktur p=0.177; p>0.05 . Sonuç: Hashimoto Tiroiditi olan hastalarda Vitamin D ile anti TPO arasında pozitif korelasyon tespit edilirken anti Tg ile bu korelasyon gözlenmedi.

Keywords

Vitamin D, Tiroid otoimmünitesi, Anti-Tg, Anti-TPO

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