Five cases of carcinoma of the papilla of vater with double primary malignancies and review of the literature

Abstract

We report five cases of carcinoma of the ampulla of Vater with another primary malignancy diagnosed either synchronously or asynchronously. These cases were observed in a group of ten Vaterian carcinoma cases diagnosed between 1988 and 1993. These cases include the first Vaterian carcinoma cases with previous breast and esophagus tumors and the second case in the literature with simultaneous colonic carcinoma in the absence of familial polyposis coli and/or Gardner’s syndrome. Compared with the other cancer series, the expected second primary malignancy rate in Vaterian carcinoma cases is much higher. Therefore, we suggest that, patients with an adenocarcinoma of the papilla of Vater should be investigated for the presence of another primary malignancy.

Keywords

• Carcinoma,Papilla of Vater,Double primary malignancies

References

1. Yoshida J, Morisaki T, Yamaguchi ft, et al. Carcinoma in adenoma of the ampulla of Vater synchronous with cancer of the sigmoid colon. Dig Dis Sci 1990;35:271-275