Effects of maternal intake of n-3 fatty acids on lipid profile and leptin concentration in cord blood

Year 2017, Volume: 30 Issue: 3, 169 - 176, 15.10.2017

Saime Batırel Nihal Buyukuslu Nural Bekıroglu Muazzez Garıpagaoglu

https://doi.org/10.5472/marumj.357250

Cited By: 1

Abstract

Objectives: Maternal intake of n-3 long chain polyunsaturated fatty
acids (LC-PUFAs) has positive effects on fetal development and pregnancy
outcomes. Leptin plays  an important  role in placental transportation of LC-PUFAs. In
this study, we aimed to evaluate the effects of maternal n-3 LC-PUFAs intake on
anthropometric parameters of mother and newborn,  the levels of fatty acids (FAs)  and leptin in cord blood.

        
Material and Methods:  Thirty-one
pregnant women were included. Eighteen were assigned to the control group and
13 received a supplement containing n-3 LC-PUFAs during last trimester of gestation (supplemented group). Physical examinations of
the participants were performed and additional data were collected with a questionnaire. FAs and leptin
concentrations in  cord blood samples
were analyzed using gas chromatography-mass
spectrometry (GC-MS) and enzyme-linked immunosorbent
assay (ELISA) kit respectively.

         Results:  A total amount of n-3 PUFAs  significantly increased after treatment.  n-6/n-3 PUFAs ratios and  leptin levels were lower in the supplemented group (P=0.052, P=0.140
respectively). There were
positive correlations between leptin levels and the z scores for birth weight,
height and head circumference of the newborns in the control group. The
supplementation affected leptin concentration 
to be positively correlated  with
n-6/n-3 PUFA ratios.

          Conclusion:
Daily supplementation with
n-3 PUFAs might be effective to improve mother and newborn health.

Keywords

Leptin, Fatty acids, Cord blood, Newborn, Pregnancy

Anne tarafından alınan n-3 yağ asitlerinin kordon kanı lipid profiline ve leptin konsantrasyonuna etkisi

Abstract

Amaç: Anne tarafından, n-3 uzun zincirli çoklu doymamış yağ asit (UZ-ÇDYA)’larının
 alımı, fetal gelişim ve hamilelik
sonuçları üzerine pozitif etkilidir. Leptin, UZ-ÇDYA’larının plasentadan
geçişinde önemli bir rol alır. Bu çalışmada, anne tarafından alınan UZ-ÇDYA’larının,
anne ve yenidoğanın antropometrik ölçümlerine, kordon kanındaki yağ asitlerine
ve leptin düzeylerine olan etkilerini araştırmayı amaçladık.

         Gereç
ve Yöntem: Çalışmaya 31
hamile kadın dahil edildi. Bunların 18’i kontrol grubuna alınırken 13’ü
hamileliklerinin son trimesteri boyunca, n-3 UZ-ÇDYA içeren bir ilaç aldı
(ilaçlı grup). Katılımcıların fizik muayeneleri yapıldı ve bir anket yardımıyla
ek veriler elde edildi. Kordon kanındaki yağ asitleri ve leptin
konsantrasyonları, sırasıyla gaz kromatograf kütle spektrometri  (GC-MS)  ve enzim bağlantılı immunosorbent test (ELISA)
 kiti  kullanılarak analiz edildi.

           Bulgular:
Toplam n-3 UZ-ÇDYA’ların
miktarı ilaç kullanımıyla anlamlı olarak arttı. İlaçlı grupta n-6/n-3 UZ-ÇDYA’larnın
oranı ve leptin düzeyleri daha düşüktü (P=0,052, P=0,140
sırasıyla). Kontrol grubunda, leptin düzeyleri ile yeni doğanların doğum kilosu,
boyu ve baş çevresi arasında pozitif ilişki vardı. İlaç kullanımı, leptin
konsantrasyonlarını, n-6/n-3 UZ-ÇDYA oranları ile pozitif ilişkili hale getirdi.  

             Sonuç: Günlük n-3 UZ-ÇDYA’larının alımı, anne ve yeni doğan
sağlığının iyileşmesinde etkili olabilir.  

Keywords

Leptin, Yağ asitleri, Kordon kanı, Yenidoğan, Hamilelik

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