Case Report
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Year 2025, Volume: 38 Issue: 3, 278 - 282, 10.10.2025
https://doi.org/10.5472/marumj.1800775

Abstract

References

  • Errami M, Margulis V, Huerta S. Renal cell carcinoma metastatic to the scalp. Rare Tumors 2016;8:139-41. doi: 10.4081/rt.2016.6400
  • Dashow JE, Gemmete JJ, McHugh JB, Helman J. Metastatic clear cell renal carcinoma of the palate mimicking noninvoluting congenital hemangioma, J Oral Mazillofac Surg 2011;69:1836-41. doi: 10.1016/j.joms.2010.07.050
  • Amaadour L, Atreche L, Azegrar M, et al. Cutaneous metastasis of renal cell carcinoma: a case report. J Cancer Ther 2017;8:603-7. doi: 10.4236/jct.2017.86051
  • Byun SS, Hong SK, Lee S, et al. The establishment of KORCC (KOrean Renal Cell Carcinoma) da tabase. Investig Clin Urol 2016;57:50-7. doi: 10.4111/icu.2016.57.1.50
  • de Paula TA, da Silva PS, Berriel LG. Renal cell carcinoma with cutaneous metastasis: case report. J Bras Nefrol 2010;32:213-5. doi: 10.1590/S0101.280.0201000.020.0010
  • Yeh HC, Yang S-F, Ke H L, Lee KS, Huang C H, Wu W. Renal cell carcinoma presenting with skull metastasis: a case report and literature review. Kaohsiung J Med Sci 2007;23: 475-79. doi: 10.1016/S1607-551X(08)70056-1.
  • Huang HC, Chang KP, Chen TM, Wu KF, Ueng SH. Renal cell carcinoma metastases in the head and neck. Chang Gung Med J 2006;29:59-65.
  • Snow S, Madjar D, Reizner G, MacK E, Bentz M. Renal cell carcinoma metastatic to the scalp: case report and review of the literature. Dermatol Surg 2001;27:192-4. doi: 10.1046/j.1524- 4725.2001.00115.x
  • Ishak A I, Pauzi S H, Masir N, Goh B. Multiple metastatic deposits in the head and neck region from a renal cell carcinoma. Malay J Med Sci 2010;17:71-4.
  • Anzalone CL, Cohen PR, Migden MR, Tannir NM. Mohs surgery in metastatic cancer: renal cell carcinoma solitary cutaneous metastasis and visceral tumor metastases to skin treated with microscopically controlled surgical excision. Int J Dermatol 2013;52:856-61. doi: 10.1111/ijd.12021
  • Pan D, Niall O, Sharma H, Gya D. Isolated scalp nodule in patient with undiagnosed RCC. ScientificWorldJournal 2006;6: 2430-2. doi: 10.1100/tsw.2007.377
  • Livingston WD Jr, Becker DW Jr, Lentz CW 3rd. Solitary scalp metastasis as the presenting feature of a renal carcinoma. Br J Plast Surg 1977;30:319-20. doi: 10.1016/0007-1226(77)90130-8
  • Escudier B, Eisen T, Porta C, et al. Renal cell carcinoma: ESMO clinical practice guidelines for di agnosis, treatment and follow-up. Ann Oncol 2012;23 Suppl 7: vii65-71. doi: 10.1093/annonc/mds227
  • Gong J, Maia MC, Dizman N, Govindarajan A, Pal SK. Metastasis in renal cell carcinoma: biology and implications for therapy. Asian J Urol 2016;3:286-92. doi: 10.1016/j. ajur.2016.08.006.
  • Shuch B, La Rochelle JC, Klatte T, et al. Brain metastasis from renal cell carcinoma: presenta tion, recurrence, and survival. Cancer 2008;113:1641-8. doi: 10.1002/cncr.23769
  • Motzer RJ, Escudier B, Oudard S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008;372:449-56. doi: 10.1016/S0140-6736(08)61039-9
  • Meshikhes HA, Al Khatem RS, Albusaleh HM, Alzahir AA. Metastatic renal cell carcinoma to the scalp: a case report with review of literature. Cureus 2023, 15:e34790. 10.7759/ cureus.34790. doi: 10.7759/cureus.34790
  • Yang HJ, Kang SY. Cutaneous metastatic renal cell carcinoma to the scalp . Arch Craniofac Surg 2019, 20:392-6. doi: 10.7181/ acfs.2019.00206
  • Estrada-Chavez G, Vega-Memije ME, Lacy-Niebla RM, Toussaint-Caire S. Scalp metastases of a renal cell carcinoma. Skinmed 2006, 5:148-50. doi: 10.1111/j.1540- 9740.2006.04563.x
  • Leve PP, Felício J, Carneiro R, Zagalo C. Recurrent renal cell carcinoma presenting as a cutaneous metastasis: a case report and review of the literature. Urol Ann 2021; 13:174-6. doi: 10.4103/UA.UA_2_20
  • Gandla S, Ramaswamy V, Rao V. Metastatic renal cell carcinoma in the head and neck region . Int J Otorhinolaryngol – Head Neck Surg 2018; 4:1092. doi: 10.18203/issn.2454-5929. ijohns20182721
  • Kishore M, Chauhan DS, Dogra S. Unusual presentation of renal cell carcinoma: a rare case report . J Lab Physicians 2018;10:241-4. doi: 10.4103/JLP.JLP_153_17
  • Eke N, Eghwrudjakpor P, Echem RC. Renal cell carcinoma presenting as a scalp swelling . Niger J Med 2003; 12:154-6.
  • Smyth LG, Casey RG, Quinlan DM. Renal cell carcinoma presenting as an ominous metachronous scalp metastasis. Can Urol Assoc J. 2010, 4:E64-6. doi: 10.5489/cuaj.859
  • Abbasi F, Alizadeh M, Noroozinia F, Moradi A: Cutaneous metastasis of bilateral renal cell carcinoma. J Pak Med Assoc 2013, 63:111-3.
  • Selvi F, Faquin WC, Michaelson MD, August M. Three synchronous atypical metastases of clear cell renal carcinoma to the maxillary gingiva, scalp and the distal phalanx of the fifth digit: a case report. J Oral Maxillofac Surg 2016;74:1286. e1-9. doi: 10.1016/j.joms.2016.01.054
  • Ferhatoglu MF, Senol K, Filiz AI. Skin metastasis of renal cell carcinoma: a case report . Cureus 2018; 10:e3614. doi: 10.7759/cureus.3614
  • Krogerus C, Svenning M, Pilt AP, Trøstrup H. Renal cell carcinoma presenting as a tumor on the scalp: a case report. Int J Surg Case Rep 2020; 76:56-9. doi:10.1016/j.ijscr.2020.09.122
  • Altinkaya A, Yazar S, Karadag EC, Er O. Large solitary scalp metastasis of renal cell carcinoma: a case report . Niger J Clin Pract 2021; 24:629-31. doi: 10.4103/njcp.njcp_584_19
  • ingla A, Sharma U, Makkar A, et al. Rare metastatic sites of renal cell carcinoma: a case series . Pan Afr Med J 2022; 42:26. doi: 10.11604/pamj.2022.42.26.33578
  • Singh P, Somani K. Latent distant metastasis of renal cell carcinoma to skin: a case report . Clin Case Rep 2020;8:1138- 41. doi: 10.1002/ccr3.2844
  • Hsieh JJ, Purdue MP, Signoretti S, et al. Renal cell carcinoma. Nat Rev Dis Primers 2017;3:17009. doi: 10.1038/nrdp.2017.9
  • Jindal T, Sinha RK, Mukherjee S, Karmakar D. Calvarial and cutaneous metastasis as the primary presentation of a renal cell carcinoma. BMJ Case Rep 2014;2014:2014:bcr201.320.2830. doi: 10.1136/bcr-2013-202830
  • Padala SA, Kallam A. Clear cell renal carcinoma. Treasure Island, FL; StatPearls Publishing, 2023.
  • Choueiri TK, Rini B, Garcia JA, et al. Prognostic factors associated with long-term survival in previously untreated metastatic renal cell carcinoma. Ann Oncol 2007 18:249-55. doi: 10.1093/annonc/mdl371.
  • Dowell-Esquivel C, Lee R, DiCaprio III RC, Nouri K. Sebaceous carcinoma: an updated review of pathogenesis, diagnosis, and treatment options. Arch Dermatol Res 2023;316:55. doi: 10.1007/s00403.023.02747-7
  • Bahadoram S, Davoodi M, Hassanzadeh S, Bahadoram M, Barahman M, Mafakher L. Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment. G Ital Nefrol 2022;39:2022.

Cutaneous scalp metastasis in renal cell carcinoma: A diagnostic challenge

Year 2025, Volume: 38 Issue: 3, 278 - 282, 10.10.2025
https://doi.org/10.5472/marumj.1800775

Abstract

One of the more aggressive cancers that has the potential to spread to other body parts is renal cell carcinoma (RCC). The most
frequent sites of metastasis are the lungs, liver, and bones. Reports of RCC spreading to the skin, especially the scalp, are uncommon.
While RCC metastases to the scalp are rare, they should be taken into account because of their poor prognosis and great potential
for spreading, thereby reducing life expectancy in humans. Here, we report a patient who was diagnosed with RCC and also had a
metastatic scalp lesion.

References

  • Errami M, Margulis V, Huerta S. Renal cell carcinoma metastatic to the scalp. Rare Tumors 2016;8:139-41. doi: 10.4081/rt.2016.6400
  • Dashow JE, Gemmete JJ, McHugh JB, Helman J. Metastatic clear cell renal carcinoma of the palate mimicking noninvoluting congenital hemangioma, J Oral Mazillofac Surg 2011;69:1836-41. doi: 10.1016/j.joms.2010.07.050
  • Amaadour L, Atreche L, Azegrar M, et al. Cutaneous metastasis of renal cell carcinoma: a case report. J Cancer Ther 2017;8:603-7. doi: 10.4236/jct.2017.86051
  • Byun SS, Hong SK, Lee S, et al. The establishment of KORCC (KOrean Renal Cell Carcinoma) da tabase. Investig Clin Urol 2016;57:50-7. doi: 10.4111/icu.2016.57.1.50
  • de Paula TA, da Silva PS, Berriel LG. Renal cell carcinoma with cutaneous metastasis: case report. J Bras Nefrol 2010;32:213-5. doi: 10.1590/S0101.280.0201000.020.0010
  • Yeh HC, Yang S-F, Ke H L, Lee KS, Huang C H, Wu W. Renal cell carcinoma presenting with skull metastasis: a case report and literature review. Kaohsiung J Med Sci 2007;23: 475-79. doi: 10.1016/S1607-551X(08)70056-1.
  • Huang HC, Chang KP, Chen TM, Wu KF, Ueng SH. Renal cell carcinoma metastases in the head and neck. Chang Gung Med J 2006;29:59-65.
  • Snow S, Madjar D, Reizner G, MacK E, Bentz M. Renal cell carcinoma metastatic to the scalp: case report and review of the literature. Dermatol Surg 2001;27:192-4. doi: 10.1046/j.1524- 4725.2001.00115.x
  • Ishak A I, Pauzi S H, Masir N, Goh B. Multiple metastatic deposits in the head and neck region from a renal cell carcinoma. Malay J Med Sci 2010;17:71-4.
  • Anzalone CL, Cohen PR, Migden MR, Tannir NM. Mohs surgery in metastatic cancer: renal cell carcinoma solitary cutaneous metastasis and visceral tumor metastases to skin treated with microscopically controlled surgical excision. Int J Dermatol 2013;52:856-61. doi: 10.1111/ijd.12021
  • Pan D, Niall O, Sharma H, Gya D. Isolated scalp nodule in patient with undiagnosed RCC. ScientificWorldJournal 2006;6: 2430-2. doi: 10.1100/tsw.2007.377
  • Livingston WD Jr, Becker DW Jr, Lentz CW 3rd. Solitary scalp metastasis as the presenting feature of a renal carcinoma. Br J Plast Surg 1977;30:319-20. doi: 10.1016/0007-1226(77)90130-8
  • Escudier B, Eisen T, Porta C, et al. Renal cell carcinoma: ESMO clinical practice guidelines for di agnosis, treatment and follow-up. Ann Oncol 2012;23 Suppl 7: vii65-71. doi: 10.1093/annonc/mds227
  • Gong J, Maia MC, Dizman N, Govindarajan A, Pal SK. Metastasis in renal cell carcinoma: biology and implications for therapy. Asian J Urol 2016;3:286-92. doi: 10.1016/j. ajur.2016.08.006.
  • Shuch B, La Rochelle JC, Klatte T, et al. Brain metastasis from renal cell carcinoma: presenta tion, recurrence, and survival. Cancer 2008;113:1641-8. doi: 10.1002/cncr.23769
  • Motzer RJ, Escudier B, Oudard S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008;372:449-56. doi: 10.1016/S0140-6736(08)61039-9
  • Meshikhes HA, Al Khatem RS, Albusaleh HM, Alzahir AA. Metastatic renal cell carcinoma to the scalp: a case report with review of literature. Cureus 2023, 15:e34790. 10.7759/ cureus.34790. doi: 10.7759/cureus.34790
  • Yang HJ, Kang SY. Cutaneous metastatic renal cell carcinoma to the scalp . Arch Craniofac Surg 2019, 20:392-6. doi: 10.7181/ acfs.2019.00206
  • Estrada-Chavez G, Vega-Memije ME, Lacy-Niebla RM, Toussaint-Caire S. Scalp metastases of a renal cell carcinoma. Skinmed 2006, 5:148-50. doi: 10.1111/j.1540- 9740.2006.04563.x
  • Leve PP, Felício J, Carneiro R, Zagalo C. Recurrent renal cell carcinoma presenting as a cutaneous metastasis: a case report and review of the literature. Urol Ann 2021; 13:174-6. doi: 10.4103/UA.UA_2_20
  • Gandla S, Ramaswamy V, Rao V. Metastatic renal cell carcinoma in the head and neck region . Int J Otorhinolaryngol – Head Neck Surg 2018; 4:1092. doi: 10.18203/issn.2454-5929. ijohns20182721
  • Kishore M, Chauhan DS, Dogra S. Unusual presentation of renal cell carcinoma: a rare case report . J Lab Physicians 2018;10:241-4. doi: 10.4103/JLP.JLP_153_17
  • Eke N, Eghwrudjakpor P, Echem RC. Renal cell carcinoma presenting as a scalp swelling . Niger J Med 2003; 12:154-6.
  • Smyth LG, Casey RG, Quinlan DM. Renal cell carcinoma presenting as an ominous metachronous scalp metastasis. Can Urol Assoc J. 2010, 4:E64-6. doi: 10.5489/cuaj.859
  • Abbasi F, Alizadeh M, Noroozinia F, Moradi A: Cutaneous metastasis of bilateral renal cell carcinoma. J Pak Med Assoc 2013, 63:111-3.
  • Selvi F, Faquin WC, Michaelson MD, August M. Three synchronous atypical metastases of clear cell renal carcinoma to the maxillary gingiva, scalp and the distal phalanx of the fifth digit: a case report. J Oral Maxillofac Surg 2016;74:1286. e1-9. doi: 10.1016/j.joms.2016.01.054
  • Ferhatoglu MF, Senol K, Filiz AI. Skin metastasis of renal cell carcinoma: a case report . Cureus 2018; 10:e3614. doi: 10.7759/cureus.3614
  • Krogerus C, Svenning M, Pilt AP, Trøstrup H. Renal cell carcinoma presenting as a tumor on the scalp: a case report. Int J Surg Case Rep 2020; 76:56-9. doi:10.1016/j.ijscr.2020.09.122
  • Altinkaya A, Yazar S, Karadag EC, Er O. Large solitary scalp metastasis of renal cell carcinoma: a case report . Niger J Clin Pract 2021; 24:629-31. doi: 10.4103/njcp.njcp_584_19
  • ingla A, Sharma U, Makkar A, et al. Rare metastatic sites of renal cell carcinoma: a case series . Pan Afr Med J 2022; 42:26. doi: 10.11604/pamj.2022.42.26.33578
  • Singh P, Somani K. Latent distant metastasis of renal cell carcinoma to skin: a case report . Clin Case Rep 2020;8:1138- 41. doi: 10.1002/ccr3.2844
  • Hsieh JJ, Purdue MP, Signoretti S, et al. Renal cell carcinoma. Nat Rev Dis Primers 2017;3:17009. doi: 10.1038/nrdp.2017.9
  • Jindal T, Sinha RK, Mukherjee S, Karmakar D. Calvarial and cutaneous metastasis as the primary presentation of a renal cell carcinoma. BMJ Case Rep 2014;2014:2014:bcr201.320.2830. doi: 10.1136/bcr-2013-202830
  • Padala SA, Kallam A. Clear cell renal carcinoma. Treasure Island, FL; StatPearls Publishing, 2023.
  • Choueiri TK, Rini B, Garcia JA, et al. Prognostic factors associated with long-term survival in previously untreated metastatic renal cell carcinoma. Ann Oncol 2007 18:249-55. doi: 10.1093/annonc/mdl371.
  • Dowell-Esquivel C, Lee R, DiCaprio III RC, Nouri K. Sebaceous carcinoma: an updated review of pathogenesis, diagnosis, and treatment options. Arch Dermatol Res 2023;316:55. doi: 10.1007/s00403.023.02747-7
  • Bahadoram S, Davoodi M, Hassanzadeh S, Bahadoram M, Barahman M, Mafakher L. Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment. G Ital Nefrol 2022;39:2022.
There are 37 citations in total.

Details

Primary Language English
Subjects Surgery (Other)
Journal Section Case Reports
Authors

Kavita Chauhan This is me 0009-0008-7945-8124

Kabir Singal This is me 0009-0004-4115-1195

Asmara Syed This is me 0000-0002-8895-9069

Anshoo Agarwal This is me 0000-0002-8675-3083

Syed Sajid Hussain This is me 0000-0003-3425-6293

S. Geetha Subramaniam This is me 0000-0002-4534-032X

Ekramy M. Elmorsy This is me 0000-0002-7444-2499

Publication Date October 10, 2025
Submission Date March 13, 2025
Acceptance Date April 17, 2025
Published in Issue Year 2025 Volume: 38 Issue: 3

Cite

APA Chauhan, K., Singal, K., Syed, A., … Agarwal, A. (2025). Cutaneous scalp metastasis in renal cell carcinoma: A diagnostic challenge. Marmara Medical Journal, 38(3), 278-282. https://doi.org/10.5472/marumj.1800775
AMA Chauhan K, Singal K, Syed A, et al. Cutaneous scalp metastasis in renal cell carcinoma: A diagnostic challenge. Marmara Med J. October 2025;38(3):278-282. doi:10.5472/marumj.1800775
Chicago Chauhan, Kavita, Kabir Singal, Asmara Syed, Anshoo Agarwal, Syed Sajid Hussain, S. Geetha Subramaniam, and Ekramy M. Elmorsy. “Cutaneous Scalp Metastasis in Renal Cell Carcinoma: A Diagnostic Challenge”. Marmara Medical Journal 38, no. 3 (October 2025): 278-82. https://doi.org/10.5472/marumj.1800775.
EndNote Chauhan K, Singal K, Syed A, Agarwal A, Hussain SS, Subramaniam SG, Elmorsy EM (October 1, 2025) Cutaneous scalp metastasis in renal cell carcinoma: A diagnostic challenge. Marmara Medical Journal 38 3 278–282.
IEEE K. Chauhan, K. Singal, A. Syed, A. Agarwal, S. S. Hussain, S. G. Subramaniam, and E. M. Elmorsy, “Cutaneous scalp metastasis in renal cell carcinoma: A diagnostic challenge”, Marmara Med J, vol. 38, no. 3, pp. 278–282, 2025, doi: 10.5472/marumj.1800775.
ISNAD Chauhan, Kavita et al. “Cutaneous Scalp Metastasis in Renal Cell Carcinoma: A Diagnostic Challenge”. Marmara Medical Journal 38/3 (October2025), 278-282. https://doi.org/10.5472/marumj.1800775.
JAMA Chauhan K, Singal K, Syed A, Agarwal A, Hussain SS, Subramaniam SG, Elmorsy EM. Cutaneous scalp metastasis in renal cell carcinoma: A diagnostic challenge. Marmara Med J. 2025;38:278–282.
MLA Chauhan, Kavita et al. “Cutaneous Scalp Metastasis in Renal Cell Carcinoma: A Diagnostic Challenge”. Marmara Medical Journal, vol. 38, no. 3, 2025, pp. 278-82, doi:10.5472/marumj.1800775.
Vancouver Chauhan K, Singal K, Syed A, Agarwal A, Hussain SS, Subramaniam SG, et al. Cutaneous scalp metastasis in renal cell carcinoma: A diagnostic challenge. Marmara Med J. 2025;38(3):278-82.