Potensiyometrik PVC-membran ve grafit kaplı tel elektrot yöntemiyle haloperidol’ün ampulde ve idrarda miktar tayini

Abstract

Sensör P olarak isimlendirilen yeni bir PVC membran ve sensör  G olarak isimlendirilen grafit kaplı tel Haloperidol’ün (HP)  analizi için tanımlanmıştır. Elektrotlar P ve G için sırasıyla;  Nernst denklemine göre en yüksek tepe noktası her onlu grup  için 3.7×10-6–1.0×10-2 mol/L -5.8 x 10-7 – 1.0 x 10-2 mol/L derişim  aralığında 57.4±0.8 and 61.1±0.4 mV; deteksiyon alt sınırı  (LO D) ise pH aralığı 2.5–7.5 and 2.5-8.0 için 1.6 × 10-6 mol/L  ve 4.2×10-7 mol/L olarak bulunmuştur. Tanımlanan sensörler  HP’ün diğer gişim yapan bileşiklerden ayrılabilmesi için yüksek  seçicilik göstermiştir. Bahsi geçen elektrotların kullanılmasıyla  HP’ün ampül dozaj formundan ve idrar örneklerinden analizinin  başarıyla yapılabileceği gösterilmiştir.  

Keywords

• Potensiyometri,Haloperidol,kaplanmış tel elektrot,PVC membrane elektrot,iyon-seçici elektrot

Determination of haloperidol drug in ampoules and in urine samples using a potentiometric PVC-membrane and graphite coated wire electrodes

Abstract

A new PVC membrane, called sensor P, and graphite coated wire, called sensor g,  for haloperidol drug (HP) are described. The electrodes P and C exhibit a Nernstian slope of 57.4±0.8 and 61.1±0.4 mV per decade over a wide concentration range from 3.7×10^-6–1.0×10^-2 mol/L and 5.8 x 10^-7 – 1.0 x 10^-2 mol/L and the limit of detection (LOD) of 1.6 × 10^-6 mol/L and 4.2×10^-7 mol/L over the pH range of  2.5–7.5 and 2.5-8.0 respectively. The presented sensors  show a very good selectivity for HP drug over the common interfering chemical species. The proposed electrodes were successfully used for determination of HP drug in ampoules and in urine samples with satisfactory results.

Keywords

• Potentiometry,Haloperidol drug,coated wire Electrode,PVC membranes electrode,Ion-selective electrode

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