Regular swimming exercise performed either before or after the induction of renovascular hypertension alleviates oxidative renal injury in rats

Year 2014, Volume: 18 Issue: 2, 66 - 72, 16.05.2014

Zarife Özdemir Kumral Göksel Şener Berrak Yeğen

Abstract

Epidemiological studies have shown that regular exercise and
increased aerobic fitness are associated with a decrease in allcause
mortality and morbidity, including diseases related with
high blood pressure. However, whether exercise has an antiinflammatory
impact on the pathogenesis of hypertension was
not elucidated yet. In the present study, to investigate the
potential protective and therapeutic effects of exercise training
(swimming for 30 min/day, 5 days/week for 9 weeks) on
renovascular hypertension (RVH) 10-week-old male Wistar
albino rats were divided into 4 groups as sham-operated
sedentary control group, sedentary group with RVH (2-Kidney,
1-Clip Goldblatt) and two exercised RVH groups, which had
9-week training either before the surgery or after the surgery.
Systolic blood pressures (SBP) were measured by the tail-cuff
method on a weekly basis and at the end of 12 weeks, rats were
decapitated to obtain kidneys. SBP were significantly higher in
the sedentary RVH group than the control group, whereas in
the trained RVH group measurements were not different than
those of the control animals. In the renal tissues of the
sedentary RVH group, malondialdehyde and myeloperoxidase
levels were increased with a concomitant decrease in
glutathione levels, while in the trained RVH group the levels
were not different than those of the control group. Moreover,
in the trained RVH group, superoxide dismutase and catalase
levels measured as antioxidant parameters, were also
significantly increased as compared with those of the
sedentary RVH group. Current results demonstrate that
regular moderate training controls high blood pressure in
RVH, while RVH-induced oxidative damage in renal tissue is
ameliorated through the modulation of oxidant-antioxidant
balance. Exercise training does not only improve the
circulatory functions, but it also initiates an anti-inflammatory
process to defend against the angiotensin-II-induced renal
injury.
Keywords: Exercise, hypertension, kidney, oxidative stress

Keywords

Exercise, hypertension, kidney, oxidative stress

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