Antimicrobial Susceptibility Profiles and Prevalence of ESBLS among Escherichia coli Isolates Recovered from Clinical Specimens in Different Services

Year 2019, Volume: 5 Issue: 3, 186 - 191, 31.12.2019

Tuğba Cebeci , Dilek Keskin , Ahmet Ali Gökal

https://doi.org/10.19127/mbsjohs.570826

Cited By: 1

Abstract

Objective: A
retrospective analysis of the widely used antibiotics all susceptibility
testing results from Escherichia coli cultured from clinical specimens private
hospital from (January 2016 to November 2018) was performed.

Methods: The
VITEK 2 Compact automated microbiology system is designed for automated rapid
antimicrobial susceptibility testing and identification of clinically relevant
bacteria. Minimum inhibitory concentration (MIC) results previously obtained in
recent clinical isolates with well-defined in isolates with well-characterized
resistance mechanisms with the microdilution method were re-interpreted for the
susceptible, intermediate and resistant categories using the 2018 EUCAST
breakpoints. Clinical samples are most commonly isolated from blood, sputum and
urine samples.

Results:
Escherichia coli isolates were highly resistant to ampicillin, cefuroxime and
cefixime 79,16%, 60,41% and 58,33% respectively. Resistance rate of ceftriaxon
was showed in 52,08%. When we compared to resistance of
trimethoprim/sulfamethoxazole, Escherichia coli isolates showed 51,04%
resistance rate. When it comes to the most sensitive antibiotics, sensitivity
rate of fosfomycin, nitrofurantoin, ertapenem, imipenem, meropenem, gentamicin,
and amikacin were 89,58%; 91,66%; 93,75%; 93,75%; 94,79%; 83,33%; 84,37%
respectively.

Conclusion:
Considering the antibiogram, fosfomycin, nitrofurantoin, ertapenem, imipenem,
meropenem, gentamicin and amikacin should be preferred drugs for E. coli
infection isolated from clinical samples.

Keywords

E. coli, antibiotic sensitivity, clinical specimens

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