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SPİNAL ANESTEZİ ÖNCESİ UYGULANAN KETAMİNİN KALÇA CERRAHİSİ GEÇİREN YAŞLI HASTALARDA POSTOPERATİF ANALJEZİ ÜZERİNE ETKİSİ

Year 2006, Volume: 7 Issue: 3, 25 - 29, 01.12.2006

Abstract

Giriş ve amaç:Yaşlı hastalarda ortopedik acil olguların büyük kısmını kalça kırığı operasyonları oluşturur. Buolgularda spinal veya epidural anestezi yöntemleri tercih edilmesine karşılık, hastalara pozisyon verilmesisırasında şiddetli ağrı oluşabilmektedir. Çalışmamızın amacı, kalça kırığı olan yaşlı hastalarda, spinal anesteziöncesi verilen ketamin, fentanil veya meperidinin, postoperatif analjezi üzerine etkisini araştırmaktır.Gereç ve yöntem:Ağustos 2000-Ekim 2001 tarihleri arasında kalça kırığı nedeniyle spinal anestezi altındaartroplasti uygulanan 89 yaşlı hasta retrospektif olarak incelendi. Hastalar spinal anesteziden hemen önce ağrısağaltımı için intravenöz olarak yapılan analjeziklere göre 4 gruba ayrıldı: Grup 1 (Ketamin grubu), Grup 2(Fentanil grubu) , Grup 3 (Meperidin grubu) ve Grup 4 (Kontrol grubu). Postoperatif ilk analjezik ihtiyaç zamanıve ilk 24 saatte kullanılan analjezik miktarları kaydedildi.Bulgular:Olguların yaşları 65-99 arasında değişmekteydi. İlk analjezik ihtiyaç zamanı ketamin grubunda (192dk.), fentanil (132 dk.), meperidin (129 dk.) ya da kontrol (118 dk.) gruplarına göre daha fazla iken (p=0.035),postoperatif ilk 24 saatteki analjezik tüketimi ise daha az olarak bulundu (p=0.035; p0.001).Sonuç:Travma sonrası artroplasti uygulanan yaşlı hastalarda spinal anesteziden hemen önce kullanılan ketamin,aynı amaçla kullanılan opioidlere göre postoperatif dönemde daha iyi ağrı sağaltımı sağlayabilmektedir

References

  • 1- A Cross National Perspective. Second edition. In: Abrams WB, Beers MH, Berkow R . The Merck Manual of Geriatrics, Whitehouse Station, N.J. Merck Research Laboratories, 1996; 123-29.
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  • 7- Rooke GA, Freund PR, Jacobson AF: Hemodynamic response and change in organ blood volume during spinal anesthesia in elderly men with cardiac disease. AnesthAnalg 1997; 85: 99105.
  • 8- Critchley LA, Stuart JC, Short TG, Gin T. Haemodynamic effects of subarachnoid block in elderly patients. Br JAnaesth 1994;73:46470.
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  • 12- Rawal N. Postoperatif ağrı tedavisi. In: Erdine S (ed). İstanbul: Abdi İbrahim A.Ş. Algoloji Derneği, 2002: 120-34.
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  • 14- Sarantopoulos C, Fassoulaki A. Sufentanil does not preempt pain after abdominal hysterectomy. Pain 1996; 65:273 6.
  • 15- Fassoulaki A, Sarantopoulos C, Zotou M, Papoulia D. Preemptive opioid analgesia does not influence pain after abdominal hysterectomy. Can JAnaesth 1995; 42: 109-13.
  • 16- Pjevic M, Komarcevic M, Kovacevic S, Jovanovic L, Gajic S. Preemptive analgesia in cholecystectomy using pethidine. Med Pregl 1999; 52:485-8.
  • 17- Sen S, Ozmert G, Aydin ON, Baran N, Caliskan E. The persisting analgesic effect of low-dose intravenous ketamine after spinal anaesthesia for caesarean section. Eur JAnaesth 22: 51823.
  • 18- Kararmaz A, Kaya S, Turhanoglu S, Ozyilmaz MA. Which administration route of fentanyl better enhances the spread of spinal anaesthesia: intravenous, intrathecal or both? Acta Anaesthesiol Scand 2003; 47: 10961100.
  • 19- Elia N, Tramèr MR. Ketamine and postoperative pain a quantitative systematic review of randomised trials. Pain 2005; 113: 6170.
  • 20- Himmelseher S, Durieux ME. Ketamine for perioperative pain management. Anesthesiology 2005; 102: 21120.
  • 21- Adam F, Chauvin M, Du Manoir B, Langlois M, Sessler DI, Fletcher D. Small-dose ketamine infusion improves postoperative analgesia and rehabilitation after total knee arthroplasty. Anesth Analg 2005;100:475-80.
  • 22- Lee IO, Lee IH. Systemic, but not intrathecal, ketamine produces preemptive analgesia in the rat formalin model.ActaAnaesthesiol Sin 2001; 39: 1237.
  • 23- De Kock M, Lavand'homme P, Waterloos H. 'Balanced analgesia' in the perioperative period: is there a place for ketamine? Pain 2001; 92: 37380.
  • 24- Kawamata T, Omote K, Sonoda H, Kawamata M, Namiki A. Analgesic mechanisms of ketamine in the presence and absence of peripheral inflammation. Anesthesiology 2000; 93: 5208.
  • 25- Hirota K, Lambert DG. Ketamine: its mechanism(s) of action and unusual clinical uses. Br JAnaesth 1996; 77: 4414.
  • 26- Özyalçın S. Yaşlılarda ağrı. In: Erdine S (ed). İstanbul: AbdiİbrahimA.Ş.Algoloji Derneği, 2002: 432-52.
  • 27- Xie H, Wang X, Liu G, Wang G. Analgesic effects and pharmacokinetics of a low dose of ketamine preoperatively administered epidurally or intravenously. Clin J Pain 2003; 19: 31722.

The Efects of Ketamine Administration Before Spinal Anesthesia on Postoperative Analgesia In Elderly Patients Undergoing Hip Surgery

Year 2006, Volume: 7 Issue: 3, 25 - 29, 01.12.2006

Abstract

Aim and objective: Hip fracture represents the most leading cause of orthopedics urgent casesfor elderly people. Although spinal or epidural anesthesia is preferred in those cases, the pain due to position can cause some difficulty. The aim of our study is to investigate the analgesic effect of ketamine, fentanyl, or meperidine administration when given to facilitate the position before spinal anesthesia on postoperative analgesia in elderly patients underwent hip surgery. Material Methods: Eighty-nine elderly patients who underwent hip surgery by spinal anesthesia were investigated between August 2000 and October 2001 retrospectively. The patients were divided into four groups according to the application of analgesics before spinal anesthesia: Group 1 (Ketamine group), Group 2 (Fentanyl group), Group 3 (Meperidine group) and Group 4 (Control group). The time of first analgesic request for postoperative period and total analgesic consumption at postoperative 24 hour were recorded in all patients. Results: The age range of patients was between 65 and 99. The time to first request for analgesia was significantly longer in the ketamine (192 min) group compared to the fentanyl (132 min), meperidine (129 min) and control groups (118 min) (p=0.035). The analgesic requirements first 24 h were significantly lower in ketamine group compared to other groups (p0.001). Conclusions: Intravenously administration of ketamine before spinal anesthesia may provide better analgesia compared to other opioids during postoperative period in elderly underwent hip surgery.

References

  • 1- A Cross National Perspective. Second edition. In: Abrams WB, Beers MH, Berkow R . The Merck Manual of Geriatrics, Whitehouse Station, N.J. Merck Research Laboratories, 1996; 123-29.
  • 2- Beaupre LA, Jones CA, Saunders LD, Johnston DW, Buckingham J, Majumdar SR. Best practices for elderly hip fracture patients. A systematic overview of the evidence. J Gen Intern Med 2005; 20: 1019-25.
  • 3- Kayhan Z. Lokal / bölgesel anestezi yöntemleri. Klinik Anestezi.İstanbul: Logos yayıncılık, 2004; 524-89.
  • 4- Sheehan E, Neligan M, Murray P. Hip arthroplasty, changing trends in a national tertiary referral centre. Ir J Med Sci 2002;171: 13-25.
  • 5- Morgan GE, Mikhail MS, Murray MJ, Larson CP. Regional Anesthesia&Pain Management, Clinical Anesthesiology. 3rd edition. Los Angeles: The McGraw-Hill Companies; 2002, 253-344.
  • 6- Sielenkammper A, Booke Michael. Anaesthesia and the Elderly. Current Opinion inAnaesthesiology 2001; 14 :679-84.
  • 7- Rooke GA, Freund PR, Jacobson AF: Hemodynamic response and change in organ blood volume during spinal anesthesia in elderly men with cardiac disease. AnesthAnalg 1997; 85: 99105.
  • 8- Critchley LA, Stuart JC, Short TG, Gin T. Haemodynamic effects of subarachnoid block in elderly patients. Br JAnaesth 1994;73:46470.
  • 9- LevineWC, Mehta V, Landesberg G.Anesthesia for the elderly: selected topics. Curr Opin Anaesthesiol 2006; 19:320-4.
  • 10- Sia S, Pelusio F,Barbagli R, Rivituso C.Analgesia before performing a spinal block in the sitting position in patients with femoral shaft fracture: a comparison between femoral nerve block and intravenous fentanyl. AnesthAnalg 2004;99:12214.
  • 11- Aubrun F. Management of postoperative analgesia in elderly patients. Reg Anesth Pain Med 2005;30:363- 79.
  • 12- Rawal N. Postoperatif ağrı tedavisi. In: Erdine S (ed). İstanbul: Abdi İbrahim A.Ş. Algoloji Derneği, 2002: 120-34.
  • 13- Kelly DJ, Ahmad M, Brull SJ. Preemptive analgesia I: physiological pathways and pharmacological modalities. Can JAnaesth 2001; 48: 10001010.
  • 14- Sarantopoulos C, Fassoulaki A. Sufentanil does not preempt pain after abdominal hysterectomy. Pain 1996; 65:273 6.
  • 15- Fassoulaki A, Sarantopoulos C, Zotou M, Papoulia D. Preemptive opioid analgesia does not influence pain after abdominal hysterectomy. Can JAnaesth 1995; 42: 109-13.
  • 16- Pjevic M, Komarcevic M, Kovacevic S, Jovanovic L, Gajic S. Preemptive analgesia in cholecystectomy using pethidine. Med Pregl 1999; 52:485-8.
  • 17- Sen S, Ozmert G, Aydin ON, Baran N, Caliskan E. The persisting analgesic effect of low-dose intravenous ketamine after spinal anaesthesia for caesarean section. Eur JAnaesth 22: 51823.
  • 18- Kararmaz A, Kaya S, Turhanoglu S, Ozyilmaz MA. Which administration route of fentanyl better enhances the spread of spinal anaesthesia: intravenous, intrathecal or both? Acta Anaesthesiol Scand 2003; 47: 10961100.
  • 19- Elia N, Tramèr MR. Ketamine and postoperative pain a quantitative systematic review of randomised trials. Pain 2005; 113: 6170.
  • 20- Himmelseher S, Durieux ME. Ketamine for perioperative pain management. Anesthesiology 2005; 102: 21120.
  • 21- Adam F, Chauvin M, Du Manoir B, Langlois M, Sessler DI, Fletcher D. Small-dose ketamine infusion improves postoperative analgesia and rehabilitation after total knee arthroplasty. Anesth Analg 2005;100:475-80.
  • 22- Lee IO, Lee IH. Systemic, but not intrathecal, ketamine produces preemptive analgesia in the rat formalin model.ActaAnaesthesiol Sin 2001; 39: 1237.
  • 23- De Kock M, Lavand'homme P, Waterloos H. 'Balanced analgesia' in the perioperative period: is there a place for ketamine? Pain 2001; 92: 37380.
  • 24- Kawamata T, Omote K, Sonoda H, Kawamata M, Namiki A. Analgesic mechanisms of ketamine in the presence and absence of peripheral inflammation. Anesthesiology 2000; 93: 5208.
  • 25- Hirota K, Lambert DG. Ketamine: its mechanism(s) of action and unusual clinical uses. Br JAnaesth 1996; 77: 4414.
  • 26- Özyalçın S. Yaşlılarda ağrı. In: Erdine S (ed). İstanbul: AbdiİbrahimA.Ş.Algoloji Derneği, 2002: 432-52.
  • 27- Xie H, Wang X, Liu G, Wang G. Analgesic effects and pharmacokinetics of a low dose of ketamine preoperatively administered epidurally or intravenously. Clin J Pain 2003; 19: 31722.
There are 27 citations in total.

Details

Other ID JA98JY42PN
Journal Section Research Article
Authors

Selda Şen This is me

Kutlay Aydın This is me

Publication Date December 1, 2006
Published in Issue Year 2006 Volume: 7 Issue: 3

Cite

EndNote Şen S, Aydın K (December 1, 2006) The Efects of Ketamine Administration Before Spinal Anesthesia on Postoperative Analgesia In Elderly Patients Undergoing Hip Surgery. Meandros Medical And Dental Journal 7 3 25–29.