Kan Gruplarının SARS-CoV-2 Enfeksiyonu ve Prognozu Üzerine Etkisi

Abstract

Amaç: Bu çalışmanın amacı, asıl/kaynak vakalar ve temaslı olan vakalarda kan gruplarının Ciddi Akut Solunum Yolu Sendromu 2 (SARS-CoV-2) riskini ve prognozu nasıl etkilediğini araştırmaktır.
Materyal ve Metot: Çalışmamız tanımlayıcı retrospektif olarak planlanmıştır. SARS-CoV-2 bulunan asıl/kaynak vakalar ile temaslı olup evde takip edilen bireyler dahil edilmiştir. Katılımcıların kan gruplarına göre dağılımları incelenmiştir. Hastalar 1.grup, kaynak/asıl vakalardan, 2.grup ev içi temaslı olup karantina sürecinde SARS-CoV-2 olan hastalar, 3.grup ev içi temaslı olup karantina sürecinde SARS-CoV-2 gelişmeyen bireyler olarak üç gruba ayrıldı.
Bulgular: Çalışmaya 1451 kişi dâhil edilmiştir. Yaş ortancası 41 idi. Gruplar arasında ABO kan grupları açısından fark yoktu ama A kan grubu 1. Grupta (% 45.4) en fazla orandaydı (p:0.61). Non-O kan grubu 2.grupta (%39.4) en fazla iken, O kan grubu da 3.grupta (%42.8) en fazla idi (p: 0.028). Rh pozitif kan grubu 1. grupta fazla idi. Rh negatif kan grubu 3. grupta daha fazla idi (p:0.000). Rh (+) kan grubu (OR:0.464, p: 0.010 ,%95 Cl: 0.306 ~ 0.703) ev içi temaslı olan vakalarda takipte enfeksiyon gelişmesini etkileyen faktörlerdendi.
Sonuç: SARS-CoV-2 ile enfekte olan hastalarda büyük oranda A, Non-O kan grubu ve Rh pozitifliği vardı. Yüksek risk taşıyan ev içi temaslılarda Rh (+) kan grubuna sahip olma enfeksiyon gelişme oranını artırmış olabilir. Bu kan grubundaki hastaların temaslı olduğu tespit edildikten sonra daha yakın takip edilmesi morbiditeyi azaltmak için gerekebilir.

Keywords

• Kan grubu
• Rh
• SARS-COV2
• ABO
• Clinical outcome

The Effect of Blood Groups on Infection and Prognosis of SARS-CoV-2

Abstract

Aim: This study aimed to investigate the effect of blood groups on the risk and prognosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the infected/source cases and contact individuals.
Material and Method: This study was designed as a descriptive and retrospective study. The individuals who were in contact with the SARS-CoV-2main/source cases and followed at home were included in the study.The distribution of the participants according to their blood groups was assessed. Patients were divided into three groups as group 1 including source/main cases, group 2 including SARS-CoV-2contacts who were living in the same house with the source case and followed up, and group 3 including contacts who were followed up in the same house but did not develop SARS-CoV-2 during the follow-up.
Results: While the rate of Non-O blood group was the highest (n=365, 39.4%) in group 2the rate of O blood group was the highest (n=190, 42.8%) in group 3 (p:0.028). While the rate of Rh positive blood group was high in group 1 that of Rh negative blood group was higher in group 3 (p:0.000). For other variables, the presence of a chronic disease was more in group 1 (p:0.000). Rh (+) blood group (OR:0.464, p:0.010, %95 Cl: 0.306 ~ 0.703) was among the factors affecting the development of the infection.
Conclusion: Patients infected with SARS-CoV-2 mostly had A, Non-O blood group and Rh positivity. Having Rh (+) blood group may have increased the rate of infection development in high-risk household contacts. After patients in this blood group were detected as contacts a closer follow-up may be necessary to decrease morbidity.

Keywords

• Blood group
• Rh
• SARS-COV2
• ABO
• Clinical Outcome

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