Kan Gruplarının SARS-CoV-2 Enfeksiyonu ve Prognozu Üzerine Etkisi

Year 2021, Volume: 3 Issue: 3, 191 - 196, 01.09.2021

Humeyra Aslaner , Mebrure Beyza Gökçek , Ali Ramazan Benli , Recep Baydemir , Zeynep Güven Gülşah Akyol , Leylagül Kaynar

https://doi.org/10.37990/medr.896945

Cited By: 1

Abstract

Amaç: Bu çalışmanın amacı, asıl/kaynak vakalar ve temaslı olan vakalarda kan gruplarının Ciddi Akut Solunum Yolu Sendromu 2 (SARS-CoV-2) riskini ve prognozu nasıl etkilediğini araştırmaktır.
Materyal ve Metot: Çalışmamız tanımlayıcı retrospektif olarak planlanmıştır. SARS-CoV-2 bulunan asıl/kaynak vakalar ile temaslı olup evde takip edilen bireyler dahil edilmiştir. Katılımcıların kan gruplarına göre dağılımları incelenmiştir. Hastalar 1.grup, kaynak/asıl vakalardan, 2.grup ev içi temaslı olup karantina sürecinde SARS-CoV-2 olan hastalar, 3.grup ev içi temaslı olup karantina sürecinde SARS-CoV-2 gelişmeyen bireyler olarak üç gruba ayrıldı.
Bulgular: Çalışmaya 1451 kişi dâhil edilmiştir. Yaş ortancası 41 idi. Gruplar arasında ABO kan grupları açısından fark yoktu ama A kan grubu 1. Grupta (% 45.4) en fazla orandaydı (p:0.61). Non-O kan grubu 2.grupta (%39.4) en fazla iken, O kan grubu da 3.grupta (%42.8) en fazla idi (p: 0.028). Rh pozitif kan grubu 1. grupta fazla idi. Rh negatif kan grubu 3. grupta daha fazla idi (p:0.000). Rh (+) kan grubu (OR:0.464, p: 0.010 ,%95 Cl: 0.306 ~ 0.703) ev içi temaslı olan vakalarda takipte enfeksiyon gelişmesini etkileyen faktörlerdendi.
Sonuç: SARS-CoV-2 ile enfekte olan hastalarda büyük oranda A, Non-O kan grubu ve Rh pozitifliği vardı. Yüksek risk taşıyan ev içi temaslılarda Rh (+) kan grubuna sahip olma enfeksiyon gelişme oranını artırmış olabilir. Bu kan grubundaki hastaların temaslı olduğu tespit edildikten sonra daha yakın takip edilmesi morbiditeyi azaltmak için gerekebilir.

Keywords

Kan grubu, Rh, SARS-COV2, ABO, Clinical outcome

The Effect of Blood Groups on Infection and Prognosis of SARS-CoV-2

Abstract

Aim: This study aimed to investigate the effect of blood groups on the risk and prognosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the infected/source cases and contact individuals.
Material and Method: This study was designed as a descriptive and retrospective study. The individuals who were in contact with the SARS-CoV-2main/source cases and followed at home were included in the study.The distribution of the participants according to their blood groups was assessed. Patients were divided into three groups as group 1 including source/main cases, group 2 including SARS-CoV-2contacts who were living in the same house with the source case and followed up, and group 3 including contacts who were followed up in the same house but did not develop SARS-CoV-2 during the follow-up.
Results: While the rate of Non-O blood group was the highest (n=365, 39.4%) in group 2the rate of O blood group was the highest (n=190, 42.8%) in group 3 (p:0.028). While the rate of Rh positive blood group was high in group 1 that of Rh negative blood group was higher in group 3 (p:0.000). For other variables, the presence of a chronic disease was more in group 1 (p:0.000). Rh (+) blood group (OR:0.464, p:0.010, %95 Cl: 0.306 ~ 0.703) was among the factors affecting the development of the infection.
Conclusion: Patients infected with SARS-CoV-2 mostly had A, Non-O blood group and Rh positivity. Having Rh (+) blood group may have increased the rate of infection development in high-risk household contacts. After patients in this blood group were detected as contacts a closer follow-up may be necessary to decrease morbidity.

Keywords

Blood group, Rh, SARS-COV2, ABO, Clinical Outcome

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