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Kan Gruplarının SARS-CoV-2 Enfeksiyonu ve Prognozu Üzerine Etkisi

Yıl 2021, Cilt 3, Sayı 3, 191 - 196, 01.09.2021
https://doi.org/10.37990/medr.896945

Öz

Amaç: Bu çalışmanın amacı, asıl/kaynak vakalar ve temaslı olan vakalarda kan gruplarının Ciddi Akut Solunum Yolu Sendromu 2 (SARS-CoV-2) riskini ve prognozu nasıl etkilediğini araştırmaktır.
Materyal ve Metot: Çalışmamız tanımlayıcı retrospektif olarak planlanmıştır. SARS-CoV-2 bulunan asıl/kaynak vakalar ile temaslı olup evde takip edilen bireyler dahil edilmiştir. Katılımcıların kan gruplarına göre dağılımları incelenmiştir. Hastalar 1.grup, kaynak/asıl vakalardan, 2.grup ev içi temaslı olup karantina sürecinde SARS-CoV-2 olan hastalar, 3.grup ev içi temaslı olup karantina sürecinde SARS-CoV-2 gelişmeyen bireyler olarak üç gruba ayrıldı.
Bulgular: Çalışmaya 1451 kişi dâhil edilmiştir. Yaş ortancası 41 idi. Gruplar arasında ABO kan grupları açısından fark yoktu ama A kan grubu 1. Grupta (% 45.4) en fazla orandaydı (p:0.61). Non-O kan grubu 2.grupta (%39.4) en fazla iken, O kan grubu da 3.grupta (%42.8) en fazla idi (p: 0.028). Rh pozitif kan grubu 1. grupta fazla idi. Rh negatif kan grubu 3. grupta daha fazla idi (p:0.000). Rh (+) kan grubu (OR:0.464, p: 0.010 ,%95 Cl: 0.306 ~ 0.703) ev içi temaslı olan vakalarda takipte enfeksiyon gelişmesini etkileyen faktörlerdendi.
Sonuç: SARS-CoV-2 ile enfekte olan hastalarda büyük oranda A, Non-O kan grubu ve Rh pozitifliği vardı. Yüksek risk taşıyan ev içi temaslılarda Rh (+) kan grubuna sahip olma enfeksiyon gelişme oranını artırmış olabilir. Bu kan grubundaki hastaların temaslı olduğu tespit edildikten sonra daha yakın takip edilmesi morbiditeyi azaltmak için gerekebilir.

Kaynakça

  • 1. Holmes KV, Lai MMC, et al. Fields Virology. 1996. Coronaviridae; pp. 1075–1093.
  • 2. Ksiazek TG, Erdman D, Goldsmith CS, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med. 2003;348(20):1953-1966. doi:10.1056/NEJMoa03078.
  • 3. de Groot RJ, Baker SC, Baric RS, et al. Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group. J Virol. 2013;87(14):7790-7792. doi:10.1128/JVI.01244-13
  • 4. Zhu N, Zhang D, Wang W, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-733. doi:10.1056/NEJMoa2001017
  • 5. Zhao J, Yang Y, Huang H, et al. Relationship between the ABO Blood Group and the COVID-19 Susceptibility [published online ahead of print, 2020 Aug 4]. Clin Infect Dis. 2020;ciaa1150. doi:10.1093/cid/ciaa1150
  • 6. Avent ND, Reid ME. The Rh blood group system: a review [published correction appears in Blood 2000 Apr 1;95(7):2197]. Blood. 2000;95(2):375-387. 7. Franchini M, Capra F, Targher G, Montagnana M, Lippi G. Relationship between ABO blood group and von Willebrand factor levels: from biology to clinical implications. Thromb J. 2007;5:14. Published 2007 Sep 25. doi:10.1186/1477-9560-5-14
  • 8. Franchini M, Favaloro EJ, Targher G, Lippi G. ABO blood group, hypercoagulability, and cardiovascular and cancer risk. Crit Rev Clin Lab Sci. 2012;49(4):137-149. doi:10.3109/10408363.2012.708647
  • 9. Harris JB, Khan AI, LaRocque RC, et al. Blood group, immunity, and risk of infection with Vibrio cholerae in an area of endemicity. Infect Immun. 2005;73(11):7422-7427. doi:10.1128/IAI.73.11.7422-7427.2005.
  • 10. Göker H, Aladağ Karakulak E, Demiroğlu H, et al. The effects of blood group types on the risk of COVID-19 infection and its clinical outcome. Turk J Med Sci. 2020;50(4):679-683. Published 2020 Jun 23. doi:10.3906/sag-2005-395
  • 11. Anstee DJ. The relationship between blood groups and disease. Blood. 2010;115(23):4635-4643.
  • 12. Cheng Y, Cheng G, Chui CH, et al. ABO blood group and susceptibility to severe acute respiratory syndrome [published correction appears in JAMA. 2005 Aug 17;294(7):794. Cheng, Yufeng [corrected to Cheng, Yunfeng]]. JAMA. 2005;293(12):1450-1451. doi:10.1001/jama.293.12.1450-c
  • 13. Cserti CM, Dzik WH. The ABO blood group system and Plasmodium falciparum malaria. Blood. 2007;110(7):2250-2258. doi:10.1182/blood-2007-03-077602
  • 14. Iodice S, Maisonneuve P, Botteri E, Sandri MT, Lowenfels AB. ABO blood group and cancer. Eur J Cancer. 2010;46(18):3345-3350. doi:10.1016/j.ejca.2010.08.009
  • 15. Liu J, Zhang S, Liu M, Wan Q, Shen H, Zhang Y. Distribution of ABO/Rh blood groups and their association with hepatitis B virus infection in 3.8 million Chinese adults: A population-based cross-sectional study. J Viral Hepat. 2018;25(4):401-411. doi:10.1111/jvh.12829
  • 16. Arac E, Solmaz IH, Akkoc H, et al. Association Between the Rh Blood Group and the Covid-19 Susceptibility. Int J Hematol Oncol. 2020;30(2):81–6. doi: 10.4999/uhod.204247.
  • 17. Golinelli D, Boetto E, Maietti E, Fantini MP. The association between ABO blood group and SARS-CoV-2 infection: A meta-analysis. PLoS One. 2020;15(9):e0239508. Published 2020 Sep 18. doi:10.1371/journal.pone.0239508
  • 18. Zietz M, Zucker J, Tatonetti NP. Associations between blood type and COVID-19 infection, intubation, and death. Nat Commun. 2020;11(1):5761. Published 2020 Nov 13. doi:10.1038/s41467-020-19623-x
  • 19. Torun YA, Kaynar LG, Karakükcü C, et al. ABO and Rh Blood Group Distribution in Kayseri Province, Turkey. Turk J Haematol. 2012;29(1):97-98. doi:10.5505/tjh.2012.26918
  • 20. Wu Y, Feng Z, Li P, Yu Q. Relationship between ABO blood group distribution and clinical characteristics in patients with COVID-19. Clin Chim Acta. 2020;509:220-223. doi:10.1016/j.cca.2020.06.026
  • 21. Li J, Wang X, Chen J, Cai Y, Deng A, Yang M. Association between ABO blood groups and risk of SARS-CoV-2 pneumonia. Br J Haematol. 2020;190(1):24-27. doi:10.1111/bjh.16797
  • 22. Yaylacı S, Dheir H, İşsever K, et al. The effect of abo and rh blood group antigens on admission to intensive care unit and mortality in patients with COVID-19 infection. Rev Assoc Med Bras (1992). 2020;66Suppl 2(Suppl 2):86-90. Published 2020 Sep 21. doi:10.1590/1806-9282.66.S2.86
  • 23. Liu N, Zhang T, Ma L, et al. The impact of ABO blood group on COVID-19 infection risk and mortality: A systematic review and meta-analysis. Blood Rev. 2020;(xxxx):100785. doi:10.1016/j.blre.2020.100785
  • 24. Latz CA, DeCarlo C, Boitano L, et al. Blood type and outcomes in patients with COVID-19. Ann Hematol. 2020;99(9):2113-2118. doi:10.1007/s00277-020-04169-1
  • 25. Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-1069. doi:10.1001/jama.2020.1585
  • 26. Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-513. doi:10.1016/S0140-6736(20)30211-7
  • 27. Onder G, Rezza G, Brusaferro S. Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy [published correction appears in JAMA. 2020 Apr 28;323(16):1619]. JAMA. 2020;323(18):1775-1776. doi:10.1001/jama.2020.4683
  • 28. Yang J, Zheng Y, Gou X, et al. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. Int J Infect Dis. 2020;94:91-95. doi:10.1016/j.ijid.2020.03.017
  • 29. Espinosa OA, Zanetti ADS, Antunes EF, Longhi FG, Matos TA, Battaglini PF. Prevalence of comorbidities in patients and mortality cases affected by SARS-CoV2: a systematic review and meta-analysis. Rev Inst Med Trop Sao Paulo. 2020;62:e43. Published 2020 Jun 22. doi:10.1590/S1678-9946202062043
  • 30. Lahner E, Dilaghi E, Prestigiacomo C, et al. Prevalence of Sars-Cov-2 Infection in Health Workers (HWs) and Diagnostic Test Performance: The Experience of a Teaching Hospital in Central Italy. Int J Environ Res Public Health. 2020;17(12):4417. Published 2020 Jun 19. doi:10.3390/ijerph17124417
  • 31. Lippi G, Henry BM. Active smoking is not associated with severity of coronavirus disease 2019 (COVID-19). Eur J Intern Med. 2020;75:107-108. doi:10.1016/j.ejim.2020.03.014

The Effect of Blood Groups on Infection and Prognosis of SARS-CoV-2

Yıl 2021, Cilt 3, Sayı 3, 191 - 196, 01.09.2021
https://doi.org/10.37990/medr.896945

Öz

Aim: This study aimed to investigate the effect of blood groups on the risk and prognosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the infected/source cases and contact individuals.
Material and Method: This study was designed as a descriptive and retrospective study. The individuals who were in contact with the SARS-CoV-2main/source cases and followed at home were included in the study.The distribution of the participants according to their blood groups was assessed. Patients were divided into three groups as group 1 including source/main cases, group 2 including SARS-CoV-2contacts who were living in the same house with the source case and followed up, and group 3 including contacts who were followed up in the same house but did not develop SARS-CoV-2 during the follow-up.
Results: While the rate of Non-O blood group was the highest (n=365, 39.4%) in group 2the rate of O blood group was the highest (n=190, 42.8%) in group 3 (p:0.028). While the rate of Rh positive blood group was high in group 1 that of Rh negative blood group was higher in group 3 (p:0.000). For other variables, the presence of a chronic disease was more in group 1 (p:0.000). Rh (+) blood group (OR:0.464, p:0.010, %95 Cl: 0.306 ~ 0.703) was among the factors affecting the development of the infection.
Conclusion: Patients infected with SARS-CoV-2 mostly had A, Non-O blood group and Rh positivity. Having Rh (+) blood group may have increased the rate of infection development in high-risk household contacts. After patients in this blood group were detected as contacts a closer follow-up may be necessary to decrease morbidity.

Kaynakça

  • 1. Holmes KV, Lai MMC, et al. Fields Virology. 1996. Coronaviridae; pp. 1075–1093.
  • 2. Ksiazek TG, Erdman D, Goldsmith CS, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med. 2003;348(20):1953-1966. doi:10.1056/NEJMoa03078.
  • 3. de Groot RJ, Baker SC, Baric RS, et al. Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group. J Virol. 2013;87(14):7790-7792. doi:10.1128/JVI.01244-13
  • 4. Zhu N, Zhang D, Wang W, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-733. doi:10.1056/NEJMoa2001017
  • 5. Zhao J, Yang Y, Huang H, et al. Relationship between the ABO Blood Group and the COVID-19 Susceptibility [published online ahead of print, 2020 Aug 4]. Clin Infect Dis. 2020;ciaa1150. doi:10.1093/cid/ciaa1150
  • 6. Avent ND, Reid ME. The Rh blood group system: a review [published correction appears in Blood 2000 Apr 1;95(7):2197]. Blood. 2000;95(2):375-387. 7. Franchini M, Capra F, Targher G, Montagnana M, Lippi G. Relationship between ABO blood group and von Willebrand factor levels: from biology to clinical implications. Thromb J. 2007;5:14. Published 2007 Sep 25. doi:10.1186/1477-9560-5-14
  • 8. Franchini M, Favaloro EJ, Targher G, Lippi G. ABO blood group, hypercoagulability, and cardiovascular and cancer risk. Crit Rev Clin Lab Sci. 2012;49(4):137-149. doi:10.3109/10408363.2012.708647
  • 9. Harris JB, Khan AI, LaRocque RC, et al. Blood group, immunity, and risk of infection with Vibrio cholerae in an area of endemicity. Infect Immun. 2005;73(11):7422-7427. doi:10.1128/IAI.73.11.7422-7427.2005.
  • 10. Göker H, Aladağ Karakulak E, Demiroğlu H, et al. The effects of blood group types on the risk of COVID-19 infection and its clinical outcome. Turk J Med Sci. 2020;50(4):679-683. Published 2020 Jun 23. doi:10.3906/sag-2005-395
  • 11. Anstee DJ. The relationship between blood groups and disease. Blood. 2010;115(23):4635-4643.
  • 12. Cheng Y, Cheng G, Chui CH, et al. ABO blood group and susceptibility to severe acute respiratory syndrome [published correction appears in JAMA. 2005 Aug 17;294(7):794. Cheng, Yufeng [corrected to Cheng, Yunfeng]]. JAMA. 2005;293(12):1450-1451. doi:10.1001/jama.293.12.1450-c
  • 13. Cserti CM, Dzik WH. The ABO blood group system and Plasmodium falciparum malaria. Blood. 2007;110(7):2250-2258. doi:10.1182/blood-2007-03-077602
  • 14. Iodice S, Maisonneuve P, Botteri E, Sandri MT, Lowenfels AB. ABO blood group and cancer. Eur J Cancer. 2010;46(18):3345-3350. doi:10.1016/j.ejca.2010.08.009
  • 15. Liu J, Zhang S, Liu M, Wan Q, Shen H, Zhang Y. Distribution of ABO/Rh blood groups and their association with hepatitis B virus infection in 3.8 million Chinese adults: A population-based cross-sectional study. J Viral Hepat. 2018;25(4):401-411. doi:10.1111/jvh.12829
  • 16. Arac E, Solmaz IH, Akkoc H, et al. Association Between the Rh Blood Group and the Covid-19 Susceptibility. Int J Hematol Oncol. 2020;30(2):81–6. doi: 10.4999/uhod.204247.
  • 17. Golinelli D, Boetto E, Maietti E, Fantini MP. The association between ABO blood group and SARS-CoV-2 infection: A meta-analysis. PLoS One. 2020;15(9):e0239508. Published 2020 Sep 18. doi:10.1371/journal.pone.0239508
  • 18. Zietz M, Zucker J, Tatonetti NP. Associations between blood type and COVID-19 infection, intubation, and death. Nat Commun. 2020;11(1):5761. Published 2020 Nov 13. doi:10.1038/s41467-020-19623-x
  • 19. Torun YA, Kaynar LG, Karakükcü C, et al. ABO and Rh Blood Group Distribution in Kayseri Province, Turkey. Turk J Haematol. 2012;29(1):97-98. doi:10.5505/tjh.2012.26918
  • 20. Wu Y, Feng Z, Li P, Yu Q. Relationship between ABO blood group distribution and clinical characteristics in patients with COVID-19. Clin Chim Acta. 2020;509:220-223. doi:10.1016/j.cca.2020.06.026
  • 21. Li J, Wang X, Chen J, Cai Y, Deng A, Yang M. Association between ABO blood groups and risk of SARS-CoV-2 pneumonia. Br J Haematol. 2020;190(1):24-27. doi:10.1111/bjh.16797
  • 22. Yaylacı S, Dheir H, İşsever K, et al. The effect of abo and rh blood group antigens on admission to intensive care unit and mortality in patients with COVID-19 infection. Rev Assoc Med Bras (1992). 2020;66Suppl 2(Suppl 2):86-90. Published 2020 Sep 21. doi:10.1590/1806-9282.66.S2.86
  • 23. Liu N, Zhang T, Ma L, et al. The impact of ABO blood group on COVID-19 infection risk and mortality: A systematic review and meta-analysis. Blood Rev. 2020;(xxxx):100785. doi:10.1016/j.blre.2020.100785
  • 24. Latz CA, DeCarlo C, Boitano L, et al. Blood type and outcomes in patients with COVID-19. Ann Hematol. 2020;99(9):2113-2118. doi:10.1007/s00277-020-04169-1
  • 25. Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-1069. doi:10.1001/jama.2020.1585
  • 26. Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-513. doi:10.1016/S0140-6736(20)30211-7
  • 27. Onder G, Rezza G, Brusaferro S. Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy [published correction appears in JAMA. 2020 Apr 28;323(16):1619]. JAMA. 2020;323(18):1775-1776. doi:10.1001/jama.2020.4683
  • 28. Yang J, Zheng Y, Gou X, et al. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. Int J Infect Dis. 2020;94:91-95. doi:10.1016/j.ijid.2020.03.017
  • 29. Espinosa OA, Zanetti ADS, Antunes EF, Longhi FG, Matos TA, Battaglini PF. Prevalence of comorbidities in patients and mortality cases affected by SARS-CoV2: a systematic review and meta-analysis. Rev Inst Med Trop Sao Paulo. 2020;62:e43. Published 2020 Jun 22. doi:10.1590/S1678-9946202062043
  • 30. Lahner E, Dilaghi E, Prestigiacomo C, et al. Prevalence of Sars-Cov-2 Infection in Health Workers (HWs) and Diagnostic Test Performance: The Experience of a Teaching Hospital in Central Italy. Int J Environ Res Public Health. 2020;17(12):4417. Published 2020 Jun 19. doi:10.3390/ijerph17124417
  • 31. Lippi G, Henry BM. Active smoking is not associated with severity of coronavirus disease 2019 (COVID-19). Eur J Intern Med. 2020;75:107-108. doi:10.1016/j.ejim.2020.03.014

Ayrıntılar

Birincil Dil İngilizce
Konular Tıp
Bölüm Özgün Makaleler
Yazarlar

Humeyra ASLANER
KAYSERI CITY HOSPITAL
0000-0002-3710-3893
Türkiye


Mebrure Beyza GÖKÇEK (Sorumlu Yazar)
KAYSERİ PROVINCE HEALTH DIRECTORATE
0000-0002-6320-4102
Türkiye


Ali Ramazan BENLİ
KARABUK UNIVERSITY
0000-0003-0039-1497
Türkiye


Recep BAYDEMİR
ERCIYES UNIVERSITY
0000-0001-9753-8461
Türkiye


Zeynep GÜVEN Bu kişi benim
ERCIYES UNIVERSITY
0000-0003-1600-9731
Türkiye


Gülşah AKYOL
KAYSERI CITY HOSPITAL
0000-0003-1909-5938
Türkiye


Leylagül KAYNAR
ERCIYES UNIVERSITY
0000-0002-2035-9462
Türkiye

Yayımlanma Tarihi 1 Eylül 2021
Yayınlandığı Sayı Yıl 2021, Cilt 3, Sayı 3

Kaynak Göster

Vancouver Aslaner H. , Gökçek M. B. , Benli A. R. , Baydemir R. , Güven Z. , Akyol G. , Kaynar L. The Effect of Blood Groups on Infection and Prognosis of SARS-CoV-2. Medical Records. 2021; 3(3): 191-196.


Editor in Chief

Assoc. Prof. Zülal Öner

Address: İzmir Bakırçay University, Department of Anatomy, İzmir, Turkey
E-mail: medrecsjournal@gmail.com

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