Ganglion Cell Layer, Inner Plexiform Layer, and Choroidal Layer Correlate Better with Disorder Severity in ADHD Patients than Retinal Nerve Fiber Layer: An Optical Coherence Tomography Study

Year 2023, Volume: 5 Issue: 3, 578 - 82, 18.09.2023

Mahmut Zabit Kara , Mehmet Hamdi Örüm , Ayşe Sevgi Karadağ , Aysun Kalenderoğlu

https://doi.org/10.37990/medr.1313614

Abstract

Aim: To assess the thickness of the choroidal layer, inner plexiform layer (IPL), ganglion cell layer (GCL), and retinal nerve fiber layer (RNFL) in individuals with attention-deficit/hyperactivity disorder (ADHD).
Material and Methods: In this retrospective study, we used a spectral optical coherence tomography (OCT) device. The CPRS-48 was performed to the ADHD group.
Results: Both groups consisted of 60 subjects. There were significant differences in NS segment of RNFL (right p=0.039; left p=0.035). The mean right choroidal thickness of ADHD group was significantly lower than the control group (p=0.015). The left GCL and IPL volumes of ADHD group were significantly lower than the control group (p<0.05). In ADHD group, a significant correlation was found between right choroid and opposition (r=0.278, p<0.05) and conduct (r=0.373, p<0.01) subscales of CPRS-48; between age and right choroid (r=0.248, p<0.05). In control group, a significant correlation was found between age and right NS (r=-0.370, p<0.05), right TS (r=-0.381, p<0.05), right mean RNFL (r=-0.352, p<0.05), left NS (r=-0.397, p<0.05), right choroid (r=0.422, p<0.01), left choroid (r=0.443, p<0.01), right GCL (r=0.425, p<0.01), right IPL (r=0.446, p<0.01).
Conclusion: This study demonstrated that there is an association between disorder severity, duration of disorder, choroidal layer thickness, GCL, IPL and ADHD.

Keywords

Ganglion cell layer, inner plexiform layer, retinal nerve fiber layer, attention-deficit/hyperactivity disorder, optical coherence tomography

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