Ganglion Cell Layer, Inner Plexiform Layer, and Choroidal Layer Correlate Better with Disorder Severity in ADHD Patients than Retinal Nerve Fiber Layer: An Optical Coherence Tomography Study

Year 2023, Volume: 5 Issue: 3, 578 - 82, 18.09.2023

Mahmut Zabit Kara , Mehmet Hamdi Örüm , Ayşe Sevgi Karadağ , Aysun Kalenderoğlu

https://doi.org/10.37990/medr.1313614

Abstract

Aim: To assess the thickness of the choroidal layer, inner plexiform layer (IPL), ganglion cell layer (GCL), and retinal nerve fiber layer (RNFL) in individuals with attention-deficit/hyperactivity disorder (ADHD).
Material and Methods: In this retrospective study, we used a spectral optical coherence tomography (OCT) device. The CPRS-48 was performed to the ADHD group.
Results: Both groups consisted of 60 subjects. There were significant differences in NS segment of RNFL (right p=0.039; left p=0.035). The mean right choroidal thickness of ADHD group was significantly lower than the control group (p=0.015). The left GCL and IPL volumes of ADHD group were significantly lower than the control group (p<0.05). In ADHD group, a significant correlation was found between right choroid and opposition (r=0.278, p<0.05) and conduct (r=0.373, p<0.01) subscales of CPRS-48; between age and right choroid (r=0.248, p<0.05). In control group, a significant correlation was found between age and right NS (r=-0.370, p<0.05), right TS (r=-0.381, p<0.05), right mean RNFL (r=-0.352, p<0.05), left NS (r=-0.397, p<0.05), right choroid (r=0.422, p<0.01), left choroid (r=0.443, p<0.01), right GCL (r=0.425, p<0.01), right IPL (r=0.446, p<0.01).
Conclusion: This study demonstrated that there is an association between disorder severity, duration of disorder, choroidal layer thickness, GCL, IPL and ADHD.

Keywords

Ganglion cell layer , inner plexiform layer , retinal nerve fiber layer , attention-deficit/hyperactivity disorder , optical coherence tomography

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